Sentences with phrase «by bone cells»

Sclerostin is a protein produced by bone cells which has a negative impact on the formation of bone when expressed at high levels by decreasing bone formation, and IGF - 1 is a hormone associated with the growth of bone.

Our laboratory has studied the role of various proprotein convertases in the degradation and cell biology of FGF - 23, a peptide hormone secreted by bone cells which controls phosphate metabolism via its action in the kidney.

Thanks to this hormone, produced by bone cells, sugar is metabolized more easily.

Made by bone cells, the FGF23 hormone travels via the bloodstream to cells in all organs, where it regulates many aspects of mineral metabolism.

Not exact matches

A great study done in 2010 indicated that drinking fat - free milk immediately after whole - body resistance training and again one hour after the workout allowed participants to increase fat loss, gain greater muscle and strength, and strengthen bones by reducing bone cell turnover.

It is commonly known that calcium is required for strong bones and teeth, but it is little acknowledged that calcium is actually required by every cell in the body to function in a healthful way: from bones to nerves and muscles to blood, calcium serves a significant purpose throughout the body.

and Robison, special focus will be given this year to the everyday heroes who save lives by donating blood, bone marrow and stem cells, as well as those who volunteer as first responders in their communities.

Ordinarily, bone is built up by cells called osteoblasts and reabsorbed during growth and healing by cells called osteoclasts.

The process takes place by means of a mechanism — unveiled in this study — that inhibits the activity of the osteoblasts, the cells that produce the bone matrix so that bones can grow during childhood and youth, and remain in good condition in adulthood.

A rare genetic disease leaves its victims debilitated by transforming soft tissue cells into bone cells, creating a strange second skeleton.

The pattern and rate of this perfusion guides how the bone structure grows, just as blood does in vivo, and the physical stimulation of the cells provided by this flow is critical for proper growth.

«We have found that the bone marrow production of immune cells is affected by high blood sugar and have identified a possible molecule mediating this effect.

Overexpression of ZNF217 provides an advantage to tumor cells by allowing cells to infinitely proliferate and turning down pathways that typically tell cells to mature into functional cells (bone, blood, skin cells).

One exciting potential for Permacol is that it can be seeded with the patient's own cells, so that in the future it may be possible to repair cartilage or bone by seeding with chondrocytes or osteocytes.

In this study, we investigated the importance of oxygen by analyzing mice with a mutation that makes their bone cells behave as if they were deprived of oxygen.»

Vidaza, from Pharmion, was approved for myelodysplastic syndromes, a bone marrow disorder marked by rapidly dividing immature blood cells that no longer respond to growth - control mechanisms.

The diet increased the levels of leptin — a hormone produced by fat cells that usually signals satiety in the brain — in the bone marrow, which promoted the development of fat cells instead of bone cells.

«We believe that small subsets of metastatic tumor cells have the ability to adopt the mechanisms used by immune cells to exit the blood vessels into the lungs, the bone marrow, the brain, and other organs.

By studying the receptor for thrombopoietin, called Mpl, on blood cells in the bone marrow, the team pinpointed the cells involved in making platelets after thrombopoietin stimulation, and made an unexpected discovery.

Varghese and her team showed that they could control the differentiation of human pluripotent stem cells into functional osteoblasts — bone - building cells — simply by adding the molecule adenosine to their growth medium.

By treating stem cells — which can become fat or bone cells — with cytochalasin D - the result was clear: the stem cells became bone cells.

This work stems from a previous study by Varghese's group to understand how calcium phosphate minerals found in bone tissue induce stem cells to differentiate into osteoblasts.

Characterized by malignant alterations in the blood - forming stem cells in the bone marrow, ALL is the most common form of childhood cancer.

Researchers at the University of California San Diego have discovered an easy and efficient way to coax human pluripotent stem cells to regenerate bone tissue — by feeding them adenosine, a naturally occurring molecule in the body.

The parasites might trigger these problems, the scientists hypothesized, by upsetting the normal balance between cells known as osteoclasts, which dissolve bone, and cells called osteoblasts, which build it back up.

«This new mechanism of Runx2 overexpression can give multiple myeloma cells a bone cell - like phenotype,» Yang said of the work by her lab and collaborators.

The granulomas were in fact being guarded by mesenchymal stem cells (MSCs), which normally form fat and bone (Proceedings of the National Academy of Sciences, DOI: 10.1073 / pnas.1007967107).

Human hematopoietic stem and progenitor cells (HSPCs), derived from bone marrow, have become a primary vehicle for efforts to replace or regenerate cells destroyed by a variety of diseases.

Encased in bone and protected by a special layer of cells, it is shielded from infections and injuries — but also from many pharmaceuticals and even from the body's own immune defenses.

The postdoc, who did not want to be identified for fear of drawing unwanted attention, must now decide whether to continue with his work on stem cells — gambling that the U.S. government by summer will be inclined to grant him an extension — or spend the next half - year boning up on techniques that will help him secure a position outside the United States.

He proved it in 2003 by first X-raying mice to kill off all the stem cells in their bone marrow, then repopulating the bone with stem cells tagged with a fluorescent marker.

Writing in the journal eLife, the authors suggest that bone growth is controlled not only from within the bone itself, but by neighboring cells situated in nearby joints.

By mimicking the stiffness of bone (40 kilopascal) or cartilage (15 kilopascal), the gel causes stem cells applied to its surface to differentiate.

By monitoring stem cell differentiation on gels that mimic the stiffness and nanofibrous structure of biological tissue, researchers have identified the specific molecules that stem cells use when selecting bone and cartilage fates.

«About five percent of people have some kind of cartilage tumor in their bones, and in most cases it's because the growth - plate cartilage cells weren't fully replaced by bone tissue,» Alman said.

Here the brain, together with the surrounding liquid, is only separated from the nasal cavity by the ethmoid bone and some cell layers.

The disease model, described in a new study by a UC San Francisco - led team, involves taking skin cells from patients with the bone disease, reprogramming them in a lab dish to their embryonic state, and deriving stem cells from them.

Cohen suspects that the protein triggers off a sequence of events by which the raw stem cells — the «ancestors» of bone, cartilage, skin, ligament, marrow, muscle and tendon cells — are converted into bone cells.

Using an approach developed at Maisonneuve - Rosemont, consisting of an autograft to reduce tumour mass followed by a family allograft three to four months later to clean the bone marrow of myeloma cells with immune cells from a family donor (immunotherapy), the study resulted in a total cure rate of 41 %, a record level using this strategy.

«We found that harmine, likely by interacting with DYRK1A, increases levels of other known drivers of cell division,» said Peng Wang, PhD, Assistant Professor of Medicine, Endocrinology, Diabetes, and Bone Disease at the Icahn School of Medicine and first author of the paper.

Researchers saw that injecting the miR - 34a mimic in mice could prevent the metastasis of breast and skin cancer cells specifically to bone, mainly by disarming the metastatic niche in bone.

The team started by analyzing bone marrow samples from children with B - ALL and cataloging every protein present in the leukemia cells.

Platelets are made by enormous megakaryocyte cells in bone marrow.

However, if this process is disrupted by a decrease in NOTCH1, the cells become confused and start to act like bone cells, laying down calcium and leading to a deadly hardening of the valve.

As the cells mature, they must also be stimulated to move as they would be by bone growth and body movement in a living animal.

Trapnell and Suzuki were prompted to test the novel macrophage transplantation therapy by studies showing that resident macrophage populations (such as those residing in the lung) can self - maintain without the cells having to regenerate directly from the bone marrow.

The bone matrix being produced by cells is stained red in samples of cells that are sorted for not expressing ALPL (left), sorted for expressing ALPL (right), and left as an unsorted control (center).

Our blood is generated by blood - forming (hematopoietic) stem cells (HSCs) in the bone marrow.

Prior research with cultured tissue had shown that a mix of chemicals could change bone marrow stem cells from mice to those resembling brain cells, but when a team led by neurologist Lorraine Iacovitti of Thomas Jefferson University in Philadelphia tried the same brew on human cells, the number altered was modest.

• A Yale research team led by Diane Krause turned a single stem cell from the bone marrow of an adult mouse into lung, liver, intestinal, and skin cells for other mice.