Other major projects include systematic identification of biomarkers to improve clinical management of cardiotoxicity induced
by cancer therapies, identification of ectopic pregnancy biomarkers, and use of chemical crosslinking coupled with high resolution mass spectrometry and molecular modeling to determine structures and dynamics of large protein complexes.
Not exact matches
There are more than 80 immune - related
cancer therapies currently in clinical trials, fueled
by many billions of dollars in pharmaceutical investment from the likes of Bristol - Myers Squibb bmy, Merck mrk, Pfizer pfe, and dozens of biotechs.
Of 12 major, large - cap biopharmaceutical companies examined
by Deloitte, the industry appears to be homing in on
cancer therapies — and for a good economic reason.
And there have been developments in cellular
therapies to treat
cancer, with two treatments aiming for approval
by the end of 2017.
Publishing a commentary about Bitcoin
by an institutional economics professor is as responsible as letting a village witch doctor give lectures on the merits of proton radiation
therapy to treat
cancer («The Bitcoin myth,» March 3).
Therapy Services at Alden Long Grove includes the specialized treatment of injuries and disorders — particularly those sustained
by trauma, orthopedic or neurological injury, burns,
cancer or wounds.
Adding abiraterone to hormone
therapy at the start of treatment for prostate
cancer improves survival
by 37 per cent, according to the results of one of the largest ever clinical trials for prostate
cancer presented at the 2017 ASCO Annual Meeting in Chicago and published in the New England Journal of Medicine.
During this in depth study, an international team of researchers led
by British scientists investigated the impact of anti-hormone
therapy on samples taken from patients with prostate
cancer.
«Used in
cancer therapy, this process could increase the impact of a treatment
by heating the
cancer cells while introducing the drug compound into the tumor.»
The researchers confirmed some of these findings
by analyzing how effective radiation
therapy was in 29 colon
cancer tumors that metastasized to either the liver or lung.
«If we know which genes are damaged in a breast
cancer patient's immune system, prevention or even
therapy can be tailored
by giving vaccines or perhaps antiviral drugs to reduce the chances of recurrence,» said Friedenson.
CAR - T cell
therapy took the
cancer world
by storm in the summer of 2010.
A route used
by tumor cells to spread could be exploited to make stem cells for regenerative medicine and
cancer therapies
«Cervical
cancer patients are currently treated as a uniform group based on chemotherapy and radiation regimens that help the largest percentage of people; however, one third of these patients are not helped
by standard
therapies,» Banister said.
Moffitt
Cancer Center researchers have contributed to these advances
by developing the first test that analyzes the sensitivity of tumors to radiation
therapy.
The failure of a pancreatic
cancer therapy, announced Wednesday
by its maker Amgen, is yet another sign that a once - promising class of
cancer treatments has failed to meet expectations.
Led
by researchers at the Ohio State University Comprehensive
Cancer Center — Arthur G. James
Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James), the retrospective study suggested that a pattern of molecules called microRNA (miRNA) in tumor cells might predict patients» response to radiation
therapy.
But success could leave a lasting mark on
cancer care,
by helping hundreds of thousands of patients every year, far more than other genetically targeted
therapies.
By combining this strategy with
cancer cell - targeting materials, we should be able to develop a
therapy for glioblastoma and other challenging
cancers in the future.»
«Given the devastating impact of
cancer metastasis and the dire need for
therapies to combat tumor spread, we're highly encouraged
by these findings and excited about the therapeutic possibilities they open up.»
Most
cancer therapies are aimed at halting
cancer growth
by stopping cells from rapidly dividing.
In science news around the world, NASA's Cassini mission is about to take its final plunge into the atmosphere of Saturn after 13 years providing an unprecedented view of the planet and its moons, a fight over whether to preserve or develop of one Europe's oldest gold mining sites heats up again, the U.S. Food and Drug Administration approves the first
cancer gene
therapy for people, a U.S. court gives a green light to a $ 1 billion lawsuit brought
by the Guatemalan victims and survivors of mid — 20th century syphilis experiments
by research institutions including Johns Hopkins University, and more.
Using genomic analysis to study
cancer in dogs can help develop new therapies for humans with cancer, according to a proof - of - concept study led by the National Cancer Institute (NCI) and the Translational Genomics Research Institute (
cancer in dogs can help develop new
therapies for humans with
cancer, according to a proof - of - concept study led by the National Cancer Institute (NCI) and the Translational Genomics Research Institute (
cancer, according to a proof - of - concept study led
by the National
Cancer Institute (NCI) and the Translational Genomics Research Institute (
Cancer Institute (NCI) and the Translational Genomics Research Institute (TGen).
In managing diseases like
cancer, for instance, he often subscribes to traditional modalities offset
by therapies that reduce a drug's toxicity (and may also increase its effectiveness).
CANCER CRUSH In CAR - T cell
therapy, a
cancer treatment approved
by the FDA this year for certain blood
cancers, a patient's T cells (teal) are genetically modified to hunt down and kill
cancer cells (blue).
The researchers believe there are other disease entities, aside from
cancers, that may be significantly affected
by targeted epigenetic
therapies.
«This could be useful in developing new combination
therapies, where multiple drugs are used simultaneously to treat a
cancer by attacking different parts of the
cancer cells at the same time.»
The study, «AKR1B1 promotes basal - like breast
cancer progression
by a positive feedback loop that activates the EMT program,» which has been published in The Journal of Experimental Medicine, suggests that an inhibitor of this enzyme currently used to treat diabetes patients could be an effective
therapy for this frequently deadly form of
cancer.
The experimental
therapy, which involves administering a drug currently used in
cancer therapy trials, treats cocaine addiction
by inhibiting memories responsible for cravings.
Provenge, made
by the biotech company Dendreon, is one of a wave of extraordinarily expensive new
cancer therapies that, in clinical trials, extended survival only modestly.
My
cancer systems biology team at the University of California, Merced, is tackling diagnosis and treatment of
therapy - resistant
cancers by elucidating the network of changes within cells as a way to identify new drug targets and circumvent
cancer resistance.
Stamets furnished capsules of freeze - dried fungus for a seven - year, NIH - funded study
by Bastyr University and the University of Minnesota to determine whether turkey tail mushrooms could help breast
cancer patients whose immune systems had been compromised
by radiation
therapy.
Treatment for advanced melanoma has seen success with targeted
therapies — drugs that interfere with division and growth of
cancer cells
by targeting key molecules — especially when multiple drugs are used in combination.
Epigenetic
therapies are thought to work in two ways to fix these errors in
cancer cells —
by correcting the «position» of the gene switches and
by making the cell appear as though it's infected
by a virus, triggering the immune system.
The finding, reported
by a Stand Up to
Cancer - Prostate Cancer Foundation Dream Team in the May 21 edition of the journal Cell, is based on an analysis of tumor samples from 150 men with metastatic prostate cancer that no longer responded to standard hormone - blocking th
Cancer - Prostate
Cancer Foundation Dream Team in the May 21 edition of the journal Cell, is based on an analysis of tumor samples from 150 men with metastatic prostate cancer that no longer responded to standard hormone - blocking th
Cancer Foundation Dream Team in the May 21 edition of the journal Cell, is based on an analysis of tumor samples from 150 men with metastatic prostate
cancer that no longer responded to standard hormone - blocking th
cancer that no longer responded to standard hormone - blocking
therapy.
The gold - iron oxide core - shell nanorods may be useful in
cancer therapy, with MRI imaging enabled
by the iron oxide shell, and local heating created
by the photothermal effect on the gold nanorod core killing
cancer cells.
The study
by the University of Southern California «exemplifies a real opportunity for the oncology community, one that embraces an integrated approach to understanding
cancer progression and developing
therapies that exploit evolution rather than ignore it,» said Anderson.
«LFEX laser» enables us to generate high energy pulses of quantum beams with large current, and one can expect such medical applications as particle beam
cancer therapy and non-destructive inspection for bridges and etc. (or defect inspection
by gamma - ray beam and neutrons).
Dr. De Carvalho says: «Another important implication of our finding is that since decitabine induces an anti-viral response, which is highly immunogenic, it may be useful to combine this agent with immune
therapy to further advance personalized
cancer medicine
by boosting an individual's natural defenses to fight disease.
«Droplet explosion
by shock waves, relevant to nuclear medicine: Ion beam
cancer therapy could be improved if ion - induced shock waves are discovered.»
During the 1990s, the incidence of breast
cancer climbed
by about 15 percent, in synchrony with a growing number of women receiving hormone replacement
therapy.
«This finding could be relevant to the many thousands of individuals affected
by these
cancers and could prevent unnecessary
therapy,» said Dr. Shay, Associate Director for Education and Training for the Harold C. Simmons Comprehensive
Cancer Center at UT Southwestern.
This is why findings
by Cincinnati
Cancer Center researchers, showing that a tumor suppressive microRNA, when activated
by an anti-estrogen drug, could contribute to development of future targeted
therapies, are important.
ADT, which suppresses the production of testosterone
by either medical or surgical castration, remains the gold standard for treating advanced prostate
cancer, either alone or with radiation
therapy.
Denmeade says the combination of drugs that block testosterone production and receptors, called androgen deprivation
therapy, may make prostate
cancer more aggressive over time
by enabling prostate
cancer cells to subvert attempts to block testosterone receptors.
«
By understanding how stress accelerates invasion in aggressive breast tumor cells, this work will inform future studies into whether beta - blockers could be a useful adjuvant
therapy in the treatment of some aggressive breast
cancers.»
Previous studies, he adds, have shown that taking testosterone at the wrong time — particularly
by men with symptoms of active
cancer progression who have not yet received testosterone - blocking
therapy — can make the disease worse.
«Disrupting this circuit
by targeting any of its individual components blocks the expression of these transcription factors and significantly impairs
therapy - resistant prostate
cancer,» said TSRI Research Associate Ji - Hak Jeong, the first author of the study.
A new study led
by scientists from the Florida campus of The Scripps Research Institute (TSRI) sheds light on a signaling circuit in cells that drives
therapy resistance in prostate
cancer.
The proposed clinical trial, in which researchers would use CRISPR to engineer immune cells to fight
cancer, won approval from the Recombinant DNA Advisory Committee (RAC) at the U.S. National Institutes of Health, a panel that has traditionally vetted the safety and ethics of gene
therapy trials funded
by the U.S. government and others.