Instead, these deaths appear to occur
by cell suicide.
Not exact matches
(i) a woman's right to choose; (ii) teaching evolution in school; (iii) medical immunization of teen girls against HPV; (iv) assisted
suicide; (v) gay marriage; (vi) my right to view art and theatre deemed «offensive,» «blasphemous» or «obscene»
by theists (vii) basic $ ex education for older school children; (viii) treating drug abuse as principally a medical issue; (xi) population control; (x) buying alcohol on a Sunday; (xi) use of condoms and other contraceptives (xii) stem
cell research.
It looks like capsaicin is able to pull this off
by instructing the mitochondria in cancer
cells to undergo apoptosis,
cell suicide.
Their paper, which appears in Nature Communications, describes how an immune
cell recruited to the tumor induces the programmed
suicide, or apoptosis, of the killer T
cells harnessed
by many immunotherapies.
It does this
by triggering processes that either repair such mutations, or instruct an affected
cell to stop dividing or even commit
suicide.
If that damage is deemed too extensive
by other cellular actors that interact with p53, it triggers p53 to launch the call for the
cell to commit
suicide.
So alpha - lac may induce apoptosis
by directly causing the destruction of DNA from within the
cell's nucleus, or it may instigate the
suicide - generating caspace cascade through the mitochondria.
The protein, called Bcl - 2, is already famed among biologists for its ability to block «apoptosis,» or
cell suicide, the process
by which damaged or obsolete
cells destroy themselves.
They also tested other chemicals known to prevent the other two forms of cellular
suicide, but only CGP3466B protected mouse nerve
cells in the brain from death
by cocaine.
Ko first cloned the human GT198 gene while a postdoctoral fellow at Harvard Medical School, and subsequent studies
by her and others have shown it has multiple roles that also include regulating stem
cells,
cell suicide and turning other genes off and on.
The topical anti-fungal drug Ciclopirox causes HIV - infected
cells to commit
suicide by jamming up the
cells» powerhouse, the mitochondria — according to a study
by researchers at Rutgers New Jersey Medical School.
The scientists discovered that dinaciclib,
by interfering with UPR activation, caused multiple myeloma and myeloid leukemia
cells to initiate a form of
cell suicide known as apoptosis when exposed to agents that induced ER stress.
Its depletion of nucleotides leaves HIV capable of making just a few incomplete pieces of DNA that cause great harm to their host
by stimulating an inflammatory response, causing nearby CD4 + T
cells to commit
suicide.
This kills the
cell by liberating proteins that order it to commit
suicide (Cancer Research, DOI: 10.1158 / 0008 - 5472.
Lieberman, Dotiwala and their team were particularly struck
by how much the granzyme - sparked cascade resembles apoptosis, a controlled form of cellular
suicide that helps eliminate damaged or potentially cancerous
cells.
In the studies led
by Kanneganti, Kuriakose and colleagues first sought to identify the specific machinery that the innate immune system uses to induce
cell suicide.
The symptoms of many diseases are caused
by unwanted
cell death, and the pathogens could be triggering abnormal
cell suicide.
IL - 22 makes intestinal
cells more resistant to viral invasion, whereas IL - 18 thwarts the virus
by spurring
cells it has already infected to commit
suicide.
The next step would be immunosuppressive therapy, which could slow down viral replication
by limiting the T
cell activation and prevent the CD4 + T
cells from committing
suicide.
Researchers found TRIF signaling is able to eliminate these aberrantly activated astrocytes
by apoptosis, a
suicide program of the
cells.
There is no question that the great specificity of any one conscious perceptual experience — such as the throbbing pain of the socket following extraction of the lower right wisdom tooth, the feeling of familiarity in dj vu, the aha experience of sudden understanding, the azure blue of a high mountain vista, the despair at reading about one more
suicide bombing — is mediated
by coalitions of synchronized cortical nerve
cells and their associated targets in the satellites of the cortex, thalamus, amygdala, claustrum and basal ganglia.
Gemcitabine kills
cells by triggering their
suicide pathway.
Some researchers, for instance, have suggested that the AIDS virus may kill CD4
cells by inducing them to commit
suicide.
A TROPICAL disease that can fatally damage the heart may take hold in the human body
by causing important immune system
cells to commit
suicide, according to a Brazilian research team.
Bcl - 2 proteins play a key role in
cell survival
by protecting against a form of
cell suicide known as apoptosis.
Now, Professor Martin and colleagues have discovered that in response to specific types of
cell damage, Parkin can trigger the self - destruction of «injured» nerve
cells by switching on a controlled process of «cellular
suicide» called apoptosis.
«We assumed,» Aguirre said, «the diseases would be different from one another and that
cells would commit
suicide by their own specific pathway and that perhaps quite late they would have a common final pathway.
In this case, the trigger is a drug that interacts with the protein produced
by the «
suicide gene,» which metabolizes it into a form deadly to the
cell, causing it to commit programmed
cell death (apoptosis).
By providing an exogenous apoptotic gene, which is only transiently expressed in
cells that already have the p16 gene active, we can precisely induce the senescent
cell to commit
suicide.
It was created
by «wiring together» two natural proteins - one that detected virus entry, and another that acted as a
suicide switch that kills the infected
cell.
And after the wound is healed, they disappear, either
by committing
cell suicide or perhaps
by reverting to their original
cell type.
The topics covered
by LifeNews.com include abortion, assisted
suicide and euthanasia, bioethics issues such as human cloning and stem
cell research, campaigns and elections, and cultural legal and legislative issues as they affect the pro-life community.
• Studies have shown EGCG to literally kill off cancer
cells, especially skin, breast, lung, colon, and bladder cancers,
by turning the
cells into
suicide cells.
The drugs used in chemotherapy are designed to be toxic to cancer
cells usually
by inhibiting
cell division or causing
cell suicide (apoptosis).
They also act aggressively against cancer
by preventing cancer
cell proliferation, inducing apoptosis — or cancer
cell «
suicide» — and inhibiting the formation of new blood vessels that nourish tumor growth.
In a 2013 study, researchers had found that quercetin inhibited the growth of pancreatic cancer
cells by inducing apoptosis, or «
cell suicide.»
But because metformin may stem cancer through several different channels —
by lowering insulin, directly slowing tumor growth, or promoting
suicide by cancer
cells — it could potentially prove useful in many types of cancer.
They could be drunk, under the influence of drugs, confused about signage, distracted
by a
cell phone, following an out of date map on a GPS device, driving for kicks or even attempting
suicide.