Not exact matches
Boldrini surmised that reduced cognitive - emotional resilience
in old age may be caused
by this smaller pool of neural stem
cells, the decline
in vascularization, and reduced
cell - to -
cell connectivity within the
hippocampus.
In a new study published in Science, the laboratory of Sebastian Jessberger, professor in the Brain Research Institute of the University of Zurich, has shown for the first time the process by which neural stem cells divide and newborn neurons integrate in the adult mouse hippocampu
In a new study published
in Science, the laboratory of Sebastian Jessberger, professor in the Brain Research Institute of the University of Zurich, has shown for the first time the process by which neural stem cells divide and newborn neurons integrate in the adult mouse hippocampu
in Science, the laboratory of Sebastian Jessberger, professor
in the Brain Research Institute of the University of Zurich, has shown for the first time the process by which neural stem cells divide and newborn neurons integrate in the adult mouse hippocampu
in the Brain Research Institute of the University of Zurich, has shown for the first time the process
by which neural stem
cells divide and newborn neurons integrate
in the adult mouse hippocampu
in the adult mouse
hippocampus.
Previous studies have shown that the ability of adult mice to grow new nerve
cells in the
hippocampus can be influenced
by genetic background, Gage says, suggesting that this ability may vary widely across species.
By measuring the amount and location of the
hippocampus cell firing, the researchers were able to determine that the neurons fired
in the exact reverse order of the firing that occurred when the rat scurried from one end of the track to the other.
By examining the
hippocampus — a portion of the brain associated with the process of learning — after the rats learned to associate a sound with a motor response, scientists found that the new brain
cells injected with dye a few weeks earlier were still alive
in those that had learned the task while the
cells in those who had failed did not survive.
Chen and his team began
by studying how reactive glial
cells respond to a specific protein, NeuroD1, which is known to be important
in the formation of nerve
cells in the
hippocampus area of adult brains.
In contrast, hippocampal engram cells were activated by natural cues on the second day after receiving a foot shock, but not on day 13 — indicating engrams in the hippocampus become active immediately, but gradually fade into a «silent» stat
In contrast, hippocampal engram
cells were activated
by natural cues on the second day after receiving a foot shock, but not on day 13 — indicating engrams
in the hippocampus become active immediately, but gradually fade into a «silent» stat
in the
hippocampus become active immediately, but gradually fade into a «silent» state.
By looking at the
hippocampus in 55 post-mortem brains aged between 19 and 92, Frisén's team found that a subset of neurons
in an area of the
hippocampus called the dentate gyrus are indeed created throughout adulthood (
Cell, doi.org/ms8).
The research team selectively overexpressed a transcription factor, Klf9, only
in older neurons
in mice, which eliminated more than one - fifth of their dendritic spines, increased the number of new neurons that integrated into the
hippocampus circuitry
by two-fold, and activated neural stem
cells.
Those key
cells are called GABAergic interneurons
in the hilus of the
hippocampus, an area of the brain involved
in learning and memory and affected
by Alzheimer's disease.
The idea that the activity of a place
cell is predictive and can be modified
by learning and the behavior of other animals may make it easier to conceptualize an all - encompassing framework that ties together the
hippocampus» role
in spatial navigation with its well - established role
in learning and memory formation.
Other rodent experiments have showed increased neurogenesis
in brains of rats maintained on an alternate - day fasting diet, as evident
by increased number of newly generated neural
cells in the
hippocampus (21).
Lobelia also acts as an antidepressant
by hindering
cell proliferation
in the
hippocampus and inducing dopamine release
in the brain.