Sentences with phrase «by cellular enzymes»

Szostak knew that non-chromosomal linear DNAs in yeast normally insert themselves into chromosomes or are destroyed by cellular enzymes, presumably because they behave as if they result from random fractures.

This cycle of activation, production and stop / block goes around once a day and is also influenced by a compound called FBXL3, which flags CRY for degradation by cellular enzymes.

Not exact matches

Cyanide compounds interfere with cellular metabolism by inhibiting the cytochrome - oxidase enzyme inside the human body.

These data demonstrate that in RNA's with very different cellular functions, there are domains with similar structural and functional properties and that there is a nucleotide in M1 RNA that affects the site of cleavage by the enzyme.

Using the same computer - based approach, the team has now been able to target the c - FLIP (cellular FLICE [FADD - like IL - 1β - converting enzyme]- inhibitory) protein, known to play a key role in cancer stem cell maintenance and survival, described in previously published work by the Institute.

Suv39h1 is one of the main enzymes that chemically mark the irrelevant regions of DNA to be compacted by cellular machinery, but little is known about how it installs its tag.

He predicts that the discovery will help researchers develop very specific anti-inflammatory drugs that can subtly tweak the body's immune responses by targeting distinct ubiquitin ligases and similar enzymes involved in cellular garbage disposal.

Schulze - Makuch and his colleagues also found evidence for enzymes that are by - products of cellular metabolism.

«First aid kit in some living organisms helps fix DNA after lengthy sun exposure: New study unveils the binding mechanisms of enzymes capable of repairing DNA damaged by UV light before any risk of cellular malfunction sets in.»

Intra-and trans - cellular delivery of enzymes by direct conjugation with non-multivalent anti-ICAM molecules.

Telomere length predicts both cellular health and disease in rodent models and humans.8 Shorter telomeres predict onset of cardiometabolic diseases of aging.9 Chronic stress is associated with higher inflammation, shorter telomeres, and lower activity levels of telomerase, the cellular enzyme that elongates telomeric DNA.10, 11 Levels of amyloid beta (Aβ) proteins circulating in the blood appear to be stress - related in rodent models12 and may be affected by stress reduction, and greater Aβ42 / Aβ40 ratios are associated with lower risk of dementia.13

It is produced by photophosphorylation and cellular respiration and used by enzymes and structural proteins in many cellular processes.

By blocking of an enzyme that affects the cellular microenvironment it is possible to stop brain tumour cells from growing.

Filament formation by metabolic enzymes is a specific adaptation to an advanced state of cellular starvation.

Enhanced amyloidogenic processing of APP by the ß - site APP cleaving enzyme (BACE) and the γ - secretase complex and reduced clearance lead to increased intracellular levels of soluble oligomeric Aß, resulting in cellular dysfunction comprising e.g., synaptic failure, mitochondrial dysfunction, enhanced oxidative stress, neurotransmitter and neurotrophin depletion, inflammation, and apoptosis which is reflected in patients as clinical symptoms such as cognitive deficits [2, 3].

Additionally, the authors tested for cellular specificity by using as a convenient experimental framework in utero electroporation of a plasmid that allowed co-expression of the PLE enzyme and of a fluorescent tag (mCherry).

The cellular localization of the polymers was confirmed by subcellular fractionation of the cells, followed by digestion with endoglycosidase H (Figure 2C and Supplemental Figure 3C), an enzyme that removes N - linked glycans still in the high mannose ER form but does not affect oligosaccharide chains after the addition of sialic acid in the Golgi apparatus.

The study that will be published in the March 21 issue of the science magazine Cell describes how insulin, through the activity of an enzyme recently described by the Freiburg research team, blocks one of the most important cellular stress regulators, a protein called SKN - 1.

Both agents have antioxidant function, and selenium is used by many enzymes for cellular protection.

Our reasoning, admittedly speculative, is that (a) the cancer cellular phenotype is a wayward phenotype characterized by reduced intercellular cooperation, cooperation that is largely mediated through glycoproteins, proteoglycans, and glycosylated proteins; (b) cells evolve the cancer phenotype in part by disabling the enzymes which glycosylate proteins; (c) therefore (the speculative inference) dietary steps which downregulate glycosylation may inadvertently serve to entrench or promote the cancer phenotype.

All food contains nutrients and potential nutritional value; however, until enzymes start the digestive process, the nutrients are locked up in the cellular structure and are not yet available to be absorbed by the body.

About a decade ago, researchers discovered that the compound nicotinamide mononucleotide is rapidly converted by natural cellular enzymes into active NAD +.

Cyanide compounds interfere with cellular metabolism by inhibiting the cytochrome - oxidase enzyme inside the human body.