Sentences with phrase «by circadian clocks»

«Important metabolic functions are also heavily influenced by circadian clocks, which is why activities such as chronic night - shift work — which can cause a misalignment of this clock — increase one's risk for metabolic and autoimmune diseases such as obesity, Type 2 diabetes, cancer and multiple sclerosis,» said Dr. Akassoglou.

The findings show that oscillatory promoter - enhancer looping, controlled by the circadian clock, is one of the regulatory layers behind circadian transcription and overall 24 - hour cyclic behavior in animals.

Scientists now know they are governed, in part, by the circadian clock.

«What has become obvious over the past few years is that metabolism, all those pathways regulating how fats and carbohydrates are used, is affected by the circadian clock,» says biochemist Corinne Silva, a program director at the NIDDK.

Ribosomal biogenesis and the translation of proteins included within their processing, folding and degradation have shown to be activated during the night and controlled by the circadian clock in past studies (Jouffe et al., 2013; Panda et al., 2002).

«We are currently working to identify the relationship between the circadian clock, metabolism and the immune system, so that one day we could develop therapies to treat diseases influenced by circadian clock disruption — including not only obesity and diabetes, but also potentially multiple sclerosis and even Alzheimer's disease.»

«I had read two articles the group had published before I arrived and I was fascinated by the circadian clock.

Melatonin is a hormone produced by the pineal gland and it is controlled by the circadian clock.

This is controlled by your circadian clock (your body's natural internal clock).

Not exact matches

People naturally experience different levels of tiredness and alertness throughout the day, which is largely regulated by our circadian biological clocks.

The sleep of young babies is biologically driven, firstly by feeding patterns and the limitations of brain development, and over time by an emerging circadian clock.

By midday, the spiders» truncated circadian clocks should have reset, sparking a new round of activity.

The researchers observed that even though the subjects» days had been abnormally extended by four hours, their body temperature and melatonin and cortisol levels continued to function according to their own internal 24 - hour circadian clock.

Exposure to bright light at night resets circadian rhythms by acutely changing the amount of some clock - gene products.

Our sleep - wake cycle, or circadian rhythm, is the result of a complex balance between states of alertness and sleepiness regulated by a part of the brain called Suprachiasmatic Nucleus (SNC); in puberty, shifts in our body clocks push optimal sleep later into the evening, making it extremely difficult for most teenagers to fall asleep before 11.00 pm.

A study published by Cell Press October 16th in Cell now reveals that gut microbes in mice and humans have circadian rhythms that are controlled by the biological clock of the host in which they reside.

EPFL biologists and geneticists have uncovered how the circadian clock orchestrates the 24 - hour cycle of gene expression by regulating the structure of chromatin, the tightly wound DNA - protein complex of the cell.

In recent years, clock researchers have uncovered some of the gears and springs that keep this circadian timepiece running, largely by identifying a handful of key genes in organisms from bread mold to mice.

«By tying the heat response to the circadian clock, plants maximize their chances of survival during heat waves.»

In the original study, Scott Campbell and Patricia Murphy of Cornell University Medical College in New York state reported that by shining light on the backs of the knees of human subjects, they could shift the so - called circadian clock that governs sleep - wake cycles (Science, 16 January 1998, p. 396).

Published for all to see in this week's Science, Kay's approach is being hailed as a milestone in the science of «rhythm genetics», the push by geneticists to understand the mysterious daily, or «circadian», clocks that tick inside most living things.

«Since urine formation and excretion by the kidney is one of the most easily detectable rhythmic processes (we are forming and excreting much more urine during the day), we hypothesized that at least a part of this rhythmicity is dependent on the circadian clock mechanism,» said Dr. Tokonami.

Because the circadian clock is calibrated by exposure to sunlight, Roenneberg suspects the many hours some kids spend holed up in their dark rooms could push the clocks even later — a pattern that may be more prevalent in industrialized societies.

One of the channel's most intriguing roles is to regulate the frequency of nerve impulses conducted by the SCN, a structure located in the brain that acts as a master clock to synchronize circadian rhythms throughout the body.

Even microorganisms, which lack a nervous system, have daily cycles of activity and inactivity driven by internal body clocks known as circadian clocks.

«This year's Nobel Laureates have been studying this fundamental problem and solved the mystery of how an inner clock in most of our cells in our bodies can anticipate daily fluctuations between night and day to optimize our behavior and physiology... since the paradigm shifting discoveries by Hall, Rosbash and Young, circadian biology has developed into a highly dynamic research field with vast implications for our health and well - being.»

«Our structures of the complexes of the circadian clock proteins of cyanobacteria provided important mechanistic insights, but are static snapshots of a system that's continuously moving and changing hour by hour,» said LiWang.

Light signals from the eyes keep the internal circadian rhythm generated by clock genes coordinated with the environment.

In the current paper, knowing that MYC, a transcription factor that binds the genome through sites that are identical to the binding sites of BMAL1, the team hypothesized that aberrant MYC expression perturbs the clock by deregulating components of the circadian network in cancer cells.

LiWang's group discovered that how the proteins move hour by hour is central to cyanobacteria's circadian clock function.

The favoured theory blames disrupted circadian rhythms, set by a body clock whose timing is thrown out of kilter in autumn by the sudden shortening of the day.

Our sleep patterns, eating habits, body temperature and hormone levels are driven by the rhythmic activity of body's circadian clock.

Circadian clocks are usually «entrained» by the day - night cycle.

«Our findings suggest this is because part of the biological mechanism behind the damage is affected by a person's circadian clock and the underlying genes that control it.»

Much of the body's biological rhythms — when to eat, when to sleep, etc. — are set by a 24 - hour circadian clock, a biological timing system linked to the rising and setting of the sun.

Almost all animals have a circadian clock — an internal timer regulated by light that helps synchronise their lives to a 24 - hour cycle.

All organisms, from mammals to fungi, have daily cycles controlled by a tightly regulated internal clock, called the circadian clock.

Even in the absence of a daily cycle of light and dark, the authors report today in Current Biology, the roosters continued to crow near dawn, suggesting that the birds» cacophonous racket is indeed controlled by an internal circadian clock.

All of this suggests that circadian clocks can be cued by social roles and that the rhythms can be much more complicated than scientists thought, the team reports online today in the Proceedings of the Royal Society B. «People seem to think about daily activity patterns as something that's more or less fixed in a species,» Kempenaers says.

Humans can overrule their body clocks, but at a price: People whose circadian rhythms are regularly disrupted — by frequent jet lag or shift work, for example — are more vulnerable to diabetes, obesity, cardiovascular disease, and cancer.

Results suggest a revised model of circadian entrainment, with the adaptation of the internal clock by external time cue, resulting in a mode of photic entrainment in which light can in parallel reset central and peripheral clocks.

I. Edery, J. E. Rutila, M. Rosbash, «Phase shifting of the circadian clock by induction of the Drosophila period protein,» Science 263, 5144 (14 January 1994)

«The circadian clock — also known as the internal body clock — is largely driven by our exposure to light and the timing of when that happens.

The molecular circadian clock coordinates the body's rhythms fine - tuned by environmental cues, such as light, to the 24 - hour solar cycle.

In an apparent ironic twist to this year's prize, the quarry claimed by countless hours of sleepless toil is itself fundamental to a good night's sleep: the molecular basis of circadian rhythms — those genes and proteins whose interactions underlie the ability of us living organisms to keep our internal body clocks entrained to a 24 - hour cycle.

LA JOLLA, CA — Discovering that mouse hair has a circadian clock — a 24 - hour cycle of growth followed by restorative repair — researchers suspect that hair loss in humans from toxic cancer radiotherapy and chemotherapy might be minimized if these treatments are given late in the day.

These internal cycles may be similar to the roughly 24 - hour circadian rhythms driven by the body's internal «clock.»

Almost all of the cells in our body contain a circadian clock and are mainly controlled by a central circadian pacemaker, located in the hypothalamus of the brain.

Light sets the circadian rhythm by eliminating a key protein needed for the molecular mechanism of the body's clock, according to scientists in the March 22 issue of Science.

This discovery underscores the widespread importance of p75NTR by offering insight into how the circadian clock helps maintain the body's overall metabolic health.