Sentences with phrase «by circulating tumor cells»

Not exact matches

Chicago, GenomeWeb — A new study by researchers from Memorial Sloan Kettering Cancer Center has demonstrated the predictive power of an AR - V7 protein expression test using Epic Sciences» non-EPCAM-based circulating tumor cell detection platform, which could help guide treatment decisions for men with metastatic castration - resistant prostate cancer.

Currently marketed for research use by Biofluidica, the test's microfluidic channels use specific cancer antibodies to detect capture circulating tumor cells.

«There was this initial thought that [circulating tumor cells] are only present at late stage,» says Sollier - Christen, but she notes that in the past year, several studies using more sensitive techniques have found such cells much earlier in tumor development, even before the tumor becomes visible by conventional imaging techniques.

By masking checkpoint receptors, Yervoy and Opdivo expand the number of circulating, tumor - recognizing T cells.

Among patients with non-small cell lung cancer (NSCLC) fueled by ALK gene alterations who were being treated with crizotinib (Xalkori), a decrease in the number of circulating tumor cells (CTCs) harboring increased copies of the ALK gene over the first two months of treatment was associated with increased progression - free survival.

The size difference between tumor and healthy circulating DNA was initially discovered in animal tumor models created by inducing tumors with human cancer cells.

«This development has the potential to enable earlier detection of solid tumors through a simple blood draw by substantially improving our ability to detect very low quantities of circulating DNA derived from tumor cells,» says corresponding author Hunter Underhill, M.D., Ph.D., who initiated the research while in the lab of senior author Jay Shendure, M.D., Ph.D., a professor in genome sciences at the University of Washington.

«It could be used to check the effectiveness of treatment, by identifying the amount of tumor cells circulating.

The scientists used a highly innovative cell separation technology Parsortix ™, developed by UK company ANGLE plc that is able to capture the circulating tumor cells.

A recent clinical study by Dr. Antonarakis and colleagues showed that mCRPC in men who had AR - V7 in circulating tumor cells was resistant to the hormone drugs enzalutamide and abiraterone.

Houston Methodist researchers led by Dario Marchetti, PhD, have developed a blood test that can identify circulating tumor cells to predict breast cancer patients at risk for developing brain metastasis.

The technique, described in Biomaterials, uses gold nanoparticles and Raman scattering, a technology previously developed by Qian and Nie for cancer cell detection (2007 Nature Biotech paper, 2011 Cancer Research paper on circulating tumor cells).

«Circulating tumor cells (CTCs) have been shed by the original tumor and entered the bloodstream — they can then form into new tumors if they lodge in distant tissue,» Wang says.

Circulating cell - free DNA (cfDNA) isolated from plasma or serum by noninvasive procedures can serve as a «liquid biopsy» and has potential as a biomarker for the tumor burden and survival prediction of breast cancer (BC).

The way in which they did this was by isolating circulating tumor cells from a drawing of blood.

DENVER — Three manuscripts published in the recent issue of the Journal of Thoracic Oncology, the official journal of the International Association for the Study of Lung Cancer (IASLC), explored the versatility of liquid biopsies by identifying EGFR mutations using circulating tumor DNA (ctDNA) in urine and plasma and examining circulating tumor cells (CTCs) in plasma to predict the risk of lung cancer recurrence after surgical resection.

A technique already developed by Dr. Simeone's research team, in collaboration with Dr. Sunitha Nagrath, for isolating circulating tumor cells was the foundation for this novel approach to personalized therapeutics.

We conducted a meta - analysis in nonmetastatic breast cancer patients treated by neoadjuvant chemotherapy (NCT) to assess the clinical validity of circulating tumor cell (CTC) detection as a prognostic marker.