Recommended Test: Ask for B12 by name or
by cobalamin.
Not exact matches
This hypothesis was confirmed
by several more recent trials with sublingual or oral doses of
cobalamin between 1000 and 5000 µg.»
These patients may be identified on basis of abnormalities in serum folate and / or
cobalamin concentrations, a positive hydrogen breath test, or
by culture of duodenal juice aspirated in the course of other investigations.
Demonstration of low serum
cobalamin is the more useful finding, since it is less influenced
by diet and coprophagia and appears to relate more to the severity of clinical disease
In humans with blind intestinal loops constructed
by radical bypass surgery, there is good evidence for numbers as high as 1012 cfu / mL, and clinical consequences (eg, diarrhea, raised serum folate, low serum
cobalamin) are well documented.
Intrinsic factor (IF), a
cobalamin binding protein that promotes
cobalamin absorption in the ileum, is produced
by the stomach and pancreas in dogs.
The presence of an abnormal flora can not be predicted accurately
by measuring serum concentrations of
cobalamin and folate, so a trial with an antibiotic such as oxytetracycline (20 mg / kg PO TID 28d), ortylosin (10 mg / kg PO TID) can be undertaken.
Subnormal serum concentrations of
cobalamin are frequently documented (approximately 75 % of cases) in dogs with EPI and are likely a consequence of intrinsic factor deficiency, disrupted binding of
cobalamin to IF (
by intestinal pH, lack of proteases) and bacterial consumption of
cobalamin (Batt et al 1989; Simpson et al 1989a; Simpson et al 1993).
In the USA, Wonderlabs Pet Factor B12 https://www.wonderlabs.com/itemleft.php?itemnum=K9688 or Wonderlabs Trinfac B https://www.wonderlabs.com/itemleft.php?itemnum=6881 are products widely used (with great success supported
by before and after
Cobalamin blood tests)
by many EPI pets with low B12.