Sentences with phrase «by cyclins»

As their name suggests, these proteins are regulated by cyclins.

Therefore, this work would assess the prognostic role of the Cyclin D1 expression through immunohistochemical stain by Cyclin D1 protein scoring and quantitative value by image analysis (IOD).

The cell cycle progression of eukaryotic cells is well controlled by cyclin, cyclin - dependent kinases (cdk), and cdk inhibitors.

The routes of these multisite phosphorylation cascades are determined by precisely oriented docking interactions mediated by cyclin - specific docking motifs and by Cks1, the phospho - adaptor subunit of Cdk1.

Au - Yeung G, Lang F, Azar WJ, Mitchell C, Jarman KE, Lackovic K, Aziz D, Cullinane C, Pearson RB, Mileshkin L, Rischin D, Karst AM, Drapkin R, Etemadmoghadam D, Bowtell DD.: Selective targeting of Cyclin E1 amplified high grade serous ovarian cancer by cyclin - dependent kinase 2 and AKT inhibition.

Not exact matches

Cyclin D is synthesized during the first stage of cell replication and is believed to help drive the complex, multi-stage process, including interaction with the retinoblastoma (Rb) protein, whose function is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide.

Cell cycle - dependent regulation of the forkhead transcription factor FOXK2 by CDK - cyclin complexes.

Growth inhibition induced by antiprogestins RU - 38486, ORG - 31710, and CDB - 2914 in ovarian cancer cells involves inhibition of cyclin dependent kinase 2.

ASPM regulates symmetric stem cell division by tuning Cyclin E ubiquitination.

Regulation of cell polarity through phosphorylation of Bni4 by Pho85 G1 cyclin - dependent kinases in Saccharomyces cerevisiae.

An InCytes from MBC Selection: Regulation of Cell Polarity through Phosphorylation of Bni4 by Pho85 G1 Cyclin - dependent Kinases in Saccharomyces cerevisiae.

Centrosome amplification in CHO and DT40 cells by inactivation of cyclin - dependent kinases.

Viral Cyclins Mediate Separate Phases of Infection by Integrating Functions of Distinct Mammalian Cyclins.

Other demonstration found that Cyclin D1 staining could provide significant prognostic information, under the experimental study modulation of MCF - 7 cell line growth rate by regulated overexpression or suppression of endogenous Cyclin D1 or CDK4 levels.

These finding were exactly in accordance with Gillet et al., 1996 [24], who stated that, Cyclin D1 staining did not appear to correlate with an increased S - phase fraction as judged by flow cytometry.

Our suggestion was supported by the previous study, who stated that patients with higher Cyclin D1 expression had longer both overall survival and relapse - free survival [26].

Immunohistochemical demonstration of Cyclin D1 have become an important mean for assessing cell proliferation, therefore the immunohistological demonstration of cell cycle related antigens such as CDKs which regulated by the different cyclins could provide a good tool for assessment of cellular proliferation [11].

No significant correlation was observed between Cyclin D1 staining and S - phase % obtained by flow cytometry as illustrated in Table 5.

Wednesday, 11 June 2014 17.00 arrival and registration 18.30 dinner 19.30 Welcome addresses by organizers 19.40 keynote lecture by Dalibor Blažek Cyclins targeted: Transcriptional Cdks in human disease

Cyclin D1 has been observed in many human tumors and is likely to promote cell proliferation and differentiation by shortening the G1 / S transition.

Oncostatin M Induces Growth Arrest by Inhibition of Skp2, Cks1, and Cyclin A Expression and Induced p21 Expression

For confirming our study results, the correlation between Cyclin D1 - staining scores and the percentage of S - phase obtained by flow cytometry which showed no significant correlation between Cyclin D1 protein and increased S - phase %.

Clock genes mediate the antiproliferative function of sympathetic signaling by inhibiting G1 cyclin expression.

Cell cycle is controlled by a set of protein complexes consists of cyclins and cyclin dependant kinases (CDKs) together provide the cell an orderly progression throughout the cycle [4].

By examining the results of genome - wide association studies (GWAS) in conjunction with experiments on mouse and human red blood cells (RBCs), researchers in the lab of Whitehead Institute Founding Member Harvey Lodish have identified the protein cyclin D3 as regulating the number of cell divisions RBC progenitors undergo, which ultimately affects the resulting size and quantity of RBCs.

Undifferentiated ES cells are also characterized by elevated levels of transcripts encoding the G1 / S transition - promoting complex cyclin E1: Cdk2 and, by contrast, low levels of transcripts encoding D - type cyclins and Cdk4 / 6 inhibitors of the INK4 family (p15, p16, p18, p19; Figure 7).

González - Sarrías, A.; Ma, H.; Edmonds, M.E.; Seeram, N.P. Maple polyphenols, ginnalins A-C, induce S - and G2 / M - cell cycle arrest in colon and breast cancer cells mediated by decreasing cyclins A and D1 levels.