Sentences with phrase «by cyclization»

Because many natural products of complex topology are biosynthesized by cyclization of modular linear precursors, which are in turn derived from iterative building block assembly, the authors hypothesized that an analogous linear to cyclized strategy could be used to access all fourteen types of structures presented here.

Polyketide (PK) and nonribosomal peptides (NRP), constructed on multimodular enzymatic assembly lines, often attain the conformations that establish biological activity by cyclization constraints introduced by tailoring enzymes.

Not exact matches

Identification of reactants, transient intermediates, and products in a bimolecular enediyne coupling and cyclization cascade on a silver surface by non-contact atomic force microscopy.

Finally, there is no attempt to see if their analysis (of the degree of cyclization of aquatic archaeal glycerol dialkyl glycerol) might be affected by modern changes in the lake.