Tunneling nanotube (TNT) formation is downregulated
by cytarabine and NF -?
Not exact matches
1) Rituximab was added to the induction as the majority of PCNSL are CD20 + diffuse large B - cell lymphomas (DLBCL) and it was previously shown that the addition of rituximab to CHOP chemotherapy has improved the prognosis in DLBCL outside the brain.8 2) The intraventricular MTX /
cytarabine treatment of the Bonn protocol requiring an Ommaya reservoir was replaced
by intraspinal administration of liposomal
cytarabine in view of the expected lower risk of procedure - related infections.
The patient was treated on an acute lymphoblastic leukemia (ALL) protocol for eight cycles of hyperCVAD (cyclophosphamide, vincristine, adriamycin and decadron) alternating with MTX / Ara - C (methotrexate and
cytarabine) and achieved complete remission (CR) confirmed
by a bone marrow biopsy and
by the resolution of most of her skin lesions.
Intraspinal treatment was liposomal
cytarabine 50 mg administered
by lumbar puncture at day 2 during the four HD - MTX courses.
The winner turned out to be the paper «Targeting SAMHD1 with the Vpx protein to improve
cytarabine therapy for hematological malignancies» (DOI: 10.1038 / nm.4265), presented
by Sean Rudd.