Sentences with phrase «by cytotoxic»
New CFSE - based assay to determine susceptibility to lysis by cytotoxic T cells of leukemic precursor cells within a heterogeneous target cell population.
http://www.jimmunol.org/
Akiko Uenaka and Eiichi Nakayama identify a murine leukemia antigen recognized by cytotoxic T cells.
Uenaka A, Ono T, Akisawa T, Wada H, Yasuda T, Nakayama E. Identification of a unique antigen peptide pRL1 on BALB / c RL male 1 leukemia recognized by cytotoxic T lymphocytes and its relation to the Akt oncogene.
Thierry Boon and colleagues show that immunogenic mutagenized tumor variants (tum) express new antigens recognized by cytotoxic T lymphocytes (CTLs).
«Dengue immunity can protect against Zika virus: Researchers reveal dual Zika / dengue immunity conferred by cytotoxic T - cells.»
Histone deacetylase (HDAC) inhibitors have shown promise in «flushing out» HIV from latently infected cells, potentially exposing the reservoirs available for elimination by cytotoxic T lymphocytes (CTL), also called killer T cells.
The compound (right panel) has a scorpion - like shape with two arms grabbing EphA2 - expressing cancer cells, and a tail (brown) constituted by a cytotoxic chemotherapeutic agent (paclitaxel used in this work).
Not exact matches
They found that hepatitis in these «human hepatocyte chimeric mice» was caused by white blood cells known as cytotoxic T lymphocytes (CTLs) that were specifically targeted to hepatitis B virus.
«But in the body, within the microenvironment they create, they somehow manage to resist elimination even by our most cytotoxic therapies.»
Known as a checkpoint inhibitor, tremelimumab is an investigational monoclonal antibody that «cuts the brakes» of the immune system by targeting cytotoxic T - lymphocyte antigen 4 (CTLA - 4), a protein that can switch off a patient's immune response.
In healthy skin, CD49a + and CD49a cells are dormant, but quickly respond with inflammatory and cytotoxic effects when stimulated by IL - 15, a protein secreted from skin cells as a rapid - response defence against microbial attack.
This electron micrograph shows an oral squamous cancer cell (white) being attacked by two cytotoxic T cells (red).
The CNIC research team generated cytotoxic memory T cells specifically targeting cancer by using different methods for vaccination with tumor antigens.
«We had some indication that rapamycin would enhance the cytotoxic T cell effect, from previous experiments in both animals and humans showing that the drug produced modest effects by itself,» says Maria Castro, Ph.D., senior author of the new paper.
They compared the number of cytotoxic T cells — which help battle a virus by killing body cells that harbor it — in normal mice and animals missing IL - 33.
One way in which cancer cells flourish is by concealing themselves against cytotoxic immune cells.
The NK receptor, CD161, highly expressed by MAIT cells, modulated the cytokine but not the cytotoxic response triggered by bacteria infected cells.
Blocking chemokine responsive to -LCB- gamma -RCB--- 2 / interferon (IFN)- -LCB- gamma -RCB- inducible protein and monokine induced by IFN --LCB- gamma -RCB- activity in vivo reduces the pathogenetic but not the antiviral potential of hepatitis B virus — specific cytotoxic T lymphocytes.
Anichini A, Maccalli C, Mortarini R, Salvi S, Mazzocchi A, Squarcina P, Herlyn M, Parmiani G. Melanoma cells and normal melanocytes share antigens recognized by HLA - A2 - restricted cytotoxic T cell clones from melanoma patients.
Cytotoxic T lymphocyte antigen - 4 accumulation in the immunological synapse is regulated by TCR signal strength.
New research from La Jolla Institute for Allergy and Immunology lays the groundwork to parse how the virus interacts with its host and causes disease by pinpointing CD8 + T cells, a subset of T cells more commonly known as cytotoxic or killer T cells, as important gatekeepers that control Zika infection or limit the severity of disease.
Therefore, to overcome chemoresistance mediated by EMT, drug screening efforts have focused on eliminating the mesenchymal subpopulation by searching for drugs with preferential cytotoxic effects on mesenchymal, rather than epithelial HMLE subpopulations [7].
These agents will possibly increase the cytotoxic action of MDR - related drugs by preventing the extrusion of anticancer drugs from the target cells.
A Marked Reduction in Priming of Cytotoxic CD8 + T Cells Mediated by Stress - Induced Glucocorticoids Involves Multiple Deficiencies in Cross-Presentation by Dendritic Cells.
Furthermore, they may be cytotoxic or may instead exert an anticancer effect by acting on one or more aspects of the tumor microenvironment either alone or in combination with existing anticancer treatments [3, 4].
Exocytic responses of single leukaemic human cytotoxic T lymphocytes stimulated by agents that bypass the T cell receptor.
The films are «Killing Cancer: Cytotoxic T - Cells on Patrol» by Alex Ritter, NIH Oxford - Cambridge Scholars Program; «Companions in Discovery» by Amy Gladfelter, Dartmouth; and «Cell Repair» by Bill Bement, University of Wisconsin, Madison.
Familial hemophagocytic lymphohistiocytosis type 2 (FHL2) is a cytokine storm syndrome characterized by immune hyperactivation with viral infection due to a CD8 T cell cytotoxic killing defect secondary to a perforin deficiency.
While cytotoxic lymphocytes are known to produce anti-tumor activity, T cell response can be modulated by activating and inhibitory co-receptors.
The researchers demonstrated this by temporarily getting rid of the immune system's cancer - killing cells, called CD8 + or cytotoxic T cells, and showing that without these cells, the virus killed only the initial five percent of cancer cells.
In addition, studies showed that the elimination of residual leukemia was primarily mediated by donor CD8 + cytotoxic T lymphocytes and NK cells, whereas the inflammatory cytokines that are secreted mainly by CD4 + Th cells have a very limited role in leukemia eradication but contribute significantly to the toxicity of GVHD (55).
The targeted drug delivery appears to be a very promising strategy for controlling the biodistribution of the cytotoxic agent only on malignant tissues by linking it to tumor - targeting moiety.
Precursors of human CD4 + cytotoxic T lymphocytes identified by single - cell transcriptome analysis.
: We conclude that treatment of triple negative breast cancers with growth hormone - releasing hormone antagonists reduces tumor growth and potentiates the effects of cytotoxic therapy by nullifying drug resistance.
Powerful inhibition of experimental human pancreatic cancers by receptor targeted cytotoxic LH - RH analog AEZS - 108.
This condition may be present at birth, or it may be caused by certain infections (such as human immunodeficiency virus or HIV), or by certain cancer therapies, such as cancer - cell killing (cytotoxic) drugs, radiation, and bone marrow transplantation.
In cancer, Tregs are recruited by tumors and prevent other types of T cells, including cytotoxic T cells (also called CD8 cells) from attacking and destroying cancer cells.
In SIV - infected macaques, Picker's team found that a CMV - based vaccine cleared the virus in 50 % of the monkeys by eliciting and maintaining a powerful, but non-traditional, cytotoxic T - cell response.
Following uptake into target cells, conjugates made with the PEG4Mal linker were processed to a cytotoxic metabolite that was retained by MDR1 - expressing cells better than a metabolite of similar conjugates prepared with the nonpolar linker N - succinimidyl - 4 -(maleimidomethyl) cyclohexane -1-carboxylate (SMCC).
Reishi mushroom contains special polysaccharides called beta - glucans said to fight cancer cells by suppressing endothelial growth factor, support the immune system, and enhance cytotoxic receptors (NKG2D / NCR) killer cells.
A skin - lightening ingredient that works by inhibiting the activity of tyrosinase, by acting as a melanocyte cytotoxic inhibitor, and by increasing the cytotoxicity of melanocytes.
Borrego F, Robertson MJ, Ritz J, Pena J, Solana R. CD69 is a stimulatory receptor for natural killer cell and its cytotoxic effect is blocked by CD94 inhibitory receptor.
The fruit works against cancer by being cytotoxic to malignant cancer cells without affecting the normal, healthy cells.
Out of 600 - plus scientific studies, H2 has shown no cytotoxic effects or cytotoxic by - products in the human body.