These are caused
by damage to nerves (due to the accumulation of homocysteine and methylmalonic acid) and low neurotransmitter levels (because of the impaired synthesis of methionine, a precursor of many neurotransmitters).
Not exact matches
The DOD - funded research will target the use of Sprint specifically for amputees suffering from moderate
to severe neuropathic pain — chronic pain typically caused
by nerve damage.
For years Ullman had suffered from
nerve damage that makes it hard for him
to walk (he moves around the offices
by Segway).
Just as I started
to come
to grips with permanent
nerve damage and an array of side effects caused
by my treatments, another crisis struck.
Mackey persuaded a doctor
to cut off his left index finger, which throbbed with pain from
nerve damage caused
by radiation treatments.
And it took some time for him
to regain dexterity in his left hand after he persuaded a doctor
to cut off the index finger, which throbbed with pain from
nerve damage caused
by radiation treatments.
The
nerves in their side are palpable and they were only saved a
damaging feat at Brighton
by a daft tackle in the penalty area that allowed Rooney
to bag a late leveller.
«Either this was a direct act
by the Russian state against our country, or the Russian government lost control of this potentially catastrophically
damaging nerve agent and allowed it
to get in the hands of others,» May said.
Mrs May said: «Either this was a direct action
by the Russian state against our country, or the Russian government lost control of its potentially catastrophically
damaging nerve agent and allowed it
to get into the hands of others.»
«Moving
to non-invasive and repeatable methods of
nerve fiber measurements such as in vivo corneal confocal microscopy would enhance study of peripheral neuropathy
by enabling early detection of
damage, progression of
nerve fiber deterioration, and enable assessment of therapeutic strategies in the SIV / macaque model,» explains Dr. Mankowski.
Studies have shown that corneal
nerve fiber density, measured
by confocal microscopy, can predict diabetes - related
damage to the peripheral
nerves, called peripheral neuropathy.
Neutrophils are one of the most common types of immune cells and known
to engulf microorganisms, but they are not normally associated with peripheral
nerve damage, such as that caused
by diabetes or trauma.
Tear samples from patients with diabetes show elevated levels of substance P, which are related
to early
damage to the corneal
nerves, which may contribute
to the development of corneal ulcers and poor wound healing in patients with diabetes, according
to the pilot study
by Maria Markoulli, PhD, MOptom, FAAO, and colleagues of University of New South Wales, Sydney, Australia.
But their prominence at sites where
nerve cells are
damaged by the disease means they deserve careful scrutiny in the desperate search for ways
to arrest the most salient cause of dementia.
Arthur Neufeld and his colleagues at Washington University in St. Louis are among the labs looking for ways
to block the
nerve damage caused
by the pressure buildup.
Blocking the activity of a single enzyme can nearly halt the
nerve damage caused
by glaucoma in mice, according
to a paper in the current issue of the Proceedings of the National Academy of Sciences.
«Our data clearly showed that one of the protein receptors on white blood cells called CXCR3 brings white blood cells
to the optic
nerve in response
to production of its binding partner CXCL10
by damaged nerve tissue,» said Zhang.
Their findings, reported June 17 in the journal Neuron, could lead
to treatments for chronic pain conditions caused
by nerve damage, such as diabetic peripheral neuropathy (DPN) and post-herpetic neuralgia (PHN), as well as chronic inflammation, like rheumatoid arthritis.
Plaque hinders neuronal activity
by gumming up synapses (spaces between cells through which chemical or electrical information is transmitted), eventually
damaging nerve cell branches and leading
to neuronal death.
«However, the capillary constriction produced
by pericytes may,
by restricting the blood supply for a long time, cause further
damage to nerve cells even after the clot is removed.
They are too close
to spinal
nerves and tissue structures that could be
damaged by another operation.
Arising from the Schwann cells of the vestibular (balance)
nerve, these tumors can grow
to the point of
damaging nearby structures — and can lead
to death
by compressing the brainstem.
Celiac disease, which results from a sensitivity
to gluten, was associated with a 2.5-fold increased risk of neuropathy (
nerve damage), according
to an article published online
by JAMA Neurology.
But if the HLA - A2 gene turns out
to be the culprit, then the immune system is probably involved somehow in Alzheimer's symptoms, says Payami, perhaps
by damaging nerve cells.
RIPK1, the researchers found, inflicts
damage by directly attacking the body's myelin production plants —
nerve cells known as oligodendrocytes, which secrete the soft substance, rich in fat and protein that wraps around axons
to support their function and shield them from
damage.
A leading cause of blindness in the world especially for the elderly, glaucoma is caused
by high intra-ocular pressure in the eye which then leads
to damage to the optic
nerve.
By linking the data, CTD was able
to connect the dots and find genes that that may be key
to connecting the drug and the possibility of
nerve damage.
Ivermectin, the established drug which successfully treats the infection, is known
to be effective against minor
damage caused
to the front of the eye
by the worm, but until now scientists had very little clear evidence about the drug's role in preventing more serious effects of infection, in particular
damage to the optic
nerve.
«We found that the KPro leads
to high levels of TNFa, and that
by blocking TNFa, we can prevent the
nerve damage.»
Now used
by millions of people with Type 2 diabetes, the drug helps
to protect patients from diabetes - related complications, including blindness, kidney failure, and
nerve damage.
However, when the researchers genetically removed syntaphilin from the
nerve cells, mitochondrial transport was enhanced, allowing the
damaged mitochondria
to be replaced
by healthy mitochondria capable of producing ATP.
A study
by researchers at Henry Ford Hospital found «substantial evidence» that a regenerative process involving
damaged nerve fibers in the spinal cord could hold the key
to better functional recovery
by most stroke victims.
«How cells adapt
to help repair
damage: Genetic processes that allow cells
to transform so they can mend
damaged nerves have been identified
by scientists.»
Genetic processes that allow cells
to transform so they can mend
damaged nerves have been identified
by scientists.
To prevent collateral damage to precious nerve cells during immune skirmishes, the brain and spinal cord are tightly sealed off from the rest of the body by the blood - brain barrie
To prevent collateral
damage to precious nerve cells during immune skirmishes, the brain and spinal cord are tightly sealed off from the rest of the body by the blood - brain barrie
to precious
nerve cells during immune skirmishes, the brain and spinal cord are tightly sealed off from the rest of the body
by the blood - brain barrier.
She added that it will not be possible
to restore vision
to the woman's eye, because her optical
nerves were too
damaged by her injury.
She reports researcher Ippazio Antonazzo proposing several possible explanations, including
nerve damage caused
by diabetes making it more difficult for a person
to sense migraine pain, or some treatment normalising the activity of insulin, making migraines less likely.
Now, Professor Martin and colleagues have discovered that in response
to specific types of cell
damage, Parkin can trigger the self - destruction of «injured»
nerve cells
by switching on a controlled process of «cellular suicide» called apoptosis.
The Sheffield team led
by Dr Kurt De Vos and Dr Andy Grierson investigated the role of the C9orf72 protein in
nerve cells and found it regulates the initiation of a vital process called «autophagy», which helps the cell
to dispose of
damaged proteins and cell parts, and recycles cell nutrients.
This
damages nerve cells
by blocking their ability
to make the proteins needed for synaptic function and leads
to the death of neurons in the brain and spinal cord.
The researchers set about trying
to prevent this
nerve damage by giving mice NR before or after exposing them
to loud noises.
This research points
to exciting new possibilities for preventing or reversing the disabling vision loss caused
by age - related macular degeneration, diabetic retinopathy, retinitis pigmentosa, glaucoma, and other diseases that
damage the retina, the layer of light - sensitive
nerve cells that line the back of the eye.
Every day, week, month that goes
by, there's further
nerve damage,» said Jocelyn Duff, who lives in Massachusetts and started Cure CMT4J, a nonprofit foundation
to find a cure for her daughter, Talia.
By this, researchers demonstrated that a peripheral
nerve injury in rats would send a message from the
damaged nerve cell
to special spinal cord immune cells called «glial cells».
The new report, co-authored
by several international research groups and led
by Karolinska Institutet, shows that stem cells transplanted into
damaged or threatened
nerve tissue quickly establish direct channels, called gap junctions,
to the
nerve cells.
Current clinical gold - standard methods for assessing the structural integrity of
nerve fibers
damaged by glaucoma are only able
to detect complete loss of those fibers from the retinal layer within the eye.
Studying owl monkeys and squirrel monkeys, he found that
damage to a
nerve, or loss of one or two fingers caused the portion of the map that had lost its input
to be overtaken
by neighbouring maps, as neurons in the affected area became responsive
to other areas of skin.
Dr. Arthur Brown and his team are boosting
nerve growth in the injured spinal cord
by enhancing the nervous system's natural ability
to rewire
damaged circuits.
Previous work
by others had shown that
nerve damage, or limb amputation, led
to a reorganisation of neuronal pathways in the cortex of very young animals.
We are very excited
by the potential of this material for cardiac applications but the capacity of the material
to deliver physiological electrical stimuli while limiting infection suggests it might have potential in a number of other indications such as repairing
damaged peripheral
nerves or perhaps even spinal cord.