Sentences with phrase «by damaged dna»

It is well known that cancer is preceded by damaged DNA.

Chemotherapy drugs are often designed to kill off malignant cells by damaging their DNA until they transition to a programmed death mode called apoptosis.

Many chemotherapeutics act by damaging the DNA.

But the molecules also affect the cells of the animal ingesting the food, by damaging the DNA, proteins, and other critical parts of the cells in their body.

Chemotherapies are potent toxins delivered into the bloodstream to kill tumor cells throughout the body by damaging DNA in rapidly dividing cells.

The team at Barts Cancer Institute, part of Queen Mary University of London, have found that a molecule, called focal adhesion kinase (FAK), signals the body to repair itself after chemotherapy or radiotherapy, which kill cancer cells by damaging DNA.

Used to lighten and even skin tone, hydroquinone is banned in the UK, Australia and Japan and has been shown to enhance carcinogenic risk by damaging DNA.

Alcohol also may increase breast cancer risk by damaging DNA in cells.

Some anti-protozoal pet antibiotics work to kill the microorganisms in your pet's body by damaging its DNA, and by inhibiting cell growth and reproduction so that the infection resolves as the protozoa die off.

Some anti-protozoal antibiotics for cats work to kill the microorganisms in your cat's body by damaging its DNA, and by inhibiting cell growth and reproduction so that the infection goes away as the protozoa die off.

Not exact matches

Its drug Niraparib kills cancer cells by inhibiting the production of proteins called PARPs, which help repair damaged DNA strands, thereby hastening the death of some types of cancer cells.

This happens when environmental agents damage DNA, or when mistakes occur when a cell copies its DNA prior to cell division, as orchestrated by God.»

Researchers found that all varieties had protective properties, with the outer layers of the red variety being a particularly rich source of quercetin, and showing significant protection of DNA damage caused by free radicals.

One of the primary causes of cancer is the accumulation of DNA damage by free radicals.

By optimizing the antioxidant systems in your body, you drastically lower the amount of DNA damage that occurs and therefore lower your risk of cancer.

This exceptional food offers antioxidant and anti-inflammatory protection to your cells, preventing DNA damage caused by free radicals and reduces oxidative stress which leads to premature aging.

Just like its relative, the leafy kale, broccoli offers anti-inflammatory and antioxidant protection, reducing the DNA damage caused by free radicals and therefore the risk of chronic disease.

Chronic diseases can arise when cellular DNA is damaged, sometimes by free - radical damage.

Carcinogens may cause cancer by altering cellular metabolism or damaging DNA directly in cells, which interferes with normal biological processes.

Tepfer suspects that seeds damaged by very short wavelength UV light could germinate if they repaired that DNA damage as they grew.

By mixing DNA with an electrochemiluminescent (ECL) agent, a mixture that lights up after electrochemical reactions take place, and exposing it to extracts from cigarette smoke and e-cigarette vapor, the chemists were able to spot DNA damage.

Produced by the body, free radicals damage DNA, so some people take supplements to mop them up.

Mice with fragile beta cells that were poor at repairing DNA damage would rapidly develop diabetes when those beta cells were challenged by cellular stress.

The p53 protein helps keep cancer in check by ordering a cellular mop - up in response to DNA damage.

The study found that carfilzomib and irinotecan have a potential synergistic effect in SCLC and other Irinotecan - sensitive cancers by allowing normal DNA damage repair and enabling normal cell - cycle death.

We know that they are under stress when they are fighting cancer or other diseases, so I wondered whether anything measureable could be seen if we put them under further stress with UVA light.We found that people with cancer have DNA which is more easily damaged by ultraviolet light than other people, so the test shows the sensitivity to damage of all the DNA — the genome — in a cell.»

Dartmouth researchers previously demonstrated that STK17A is a protein that is induced when DNA is damaged by the chemotherapeutic drug cisplatin.

Many scientists believe that the aging process is caused by the gradual buildup of a huge number of individually tiny faults — some damage to a DNA strand here, a deranged protein molecule there, and so on.

«For this reason, we decided to combine vitamin C with a PARP inhibitor, a drug type known to cause cancer cell death by blocking the repair of DNA damage, and already approved for treating certain patients with ovarian cancer.»

DNA damage caused by replication errors includes copying mistakes, insertions or deletions of DNA, and chemical changes that alter the DNA's message.

A one - year sabbatical at NASA turned into two years funded by the German Research Foundation (DFG), at the end of which awaits another accolade: Dr Moreno - Villanueva's idea for developing an automated diagnostic procedure for the detection of DNA damage in space has been awarded a $ 10,000 funding grant by NASA's Johnson Space Center.

Now, results described in tomorrow's issue of Nature suggest that BRCA2 mutations could lead to cancer by interfering with cells» ability to repair damaged DNA.

«Maintaining a healthy weight may be associated with a decreased likelihood of developing breast cancer by limiting the amount of DNA damage in the breast glands.»

This stress, which is notably induced in pre-cancerous lesions, is characterised by an increased DNA replication rate, which provokes DNA damage and genome instability, major drivers of tumor formation.

Hypoxia can damage DNA and contribute to aging and cancer, so mechanisms that protect against hypoxia — by repairing DNA, for example — likely also help explain the blind mole - rat's resistance to cancer and aging, Band said.

The researchers identified a surveillance mechanism that not only monitors DNA lesions caused by epigenetic reprogramming but also fixes the damage.

Rare, deadly, and caused by a single gene mutation, it was a perfect proof - of - principle condition for anyone seeking to replace damaged DNA with genes that did the job.

Rad3 signalling ensures that cells do not divide before DNA damages are repaired and thus provides cancer cells with a mechanism to resist chemotherapy by repairing these DNA damages.

By KAREN SCHMIDT Every day of your life, each of your cells is bombarded by hostile forces that damage the DNA bases forming the alphabet of your genetic codBy KAREN SCHMIDT Every day of your life, each of your cells is bombarded by hostile forces that damage the DNA bases forming the alphabet of your genetic codby hostile forces that damage the DNA bases forming the alphabet of your genetic code.

Wyrick and his colleagues also saw less damage around transcription factors, proteins that bind to specific, short stretches of DNA and regulate gene expression by controlling which genes are turned on and off.

Because ancient DNA is almost always badly damaged, its signal is easily swamped by even a speck of more modern contaminants — anything from bacteria that invaded the bone after death to the roast beef sandwich residue on a researcher's hands.

That process, once activated, also fixes a lot of DNA damage caused by environmental stresses, including dreaded «double - strand breaks,» a clean severing of the DNA molecule.

They also found higher levels of DNA damage caused by the chronic samples.

But she's baffled by how free radicals — which have very short lifetimes and travel short distances — could reach the nucleus of even adjacent cells in time to inflict DNA damage.

A group of researchers at Osaka University found that if DNA damage response (DDR) does not work when DNA is damaged by radiation, proteins which should be removed remain instead, and a loss of genetic information can be incited, which, when repaired incorrectly, will lead to the tumor formation.

A team of chemists at the California Institute of Technology led by Jackie Barton fabricated DNA helices with built - in damage: a small kink in the helix called a thymine dimer.

This group's achievement shows the possibility to clarify the mechanism of human tumor formation, especially the molecular mechanism responsible for in the initial stage of cell cancerization due to DNA damaged by radiation in the initial stage, by using the model of budding yeast, a primitive eukaryote.

Conventional risk models used by NASA and others assume DNA damage and mutation are the cause of radiation cancers.

The protein produced by this gene protects the chromosome ends of the DNA from damage, and controls telomere maintenance by the telomerase enzyme.

According to one popular theory, when mitochondria extract energy from chemicals, by - products called oxygen radicals damage mitochondrial DNA and other critical molecules.