Not exact matches
The resulting lack of adequate blood flow can
damage heart muscle and other
tissues by depriving them of oxygen.
It detects scar
tissue formed after the
heart muscle is
damaged by a
heart attack.
Nitric Oxide protects the
heart from
damage caused
by ischemia, or blocked blood flow to
heart tissue.
A previous study from the MGH team found that injecting B cells into cardiac
tissue damaged by a
heart attack improved structural and functional recovery in an animal model.
There is a lot of work still to do, and many potential pitfalls before it could be applied to human patients, but in principle almost any illness caused
by damaged or ageing
tissue —
heart disease, diabetes, Alzheimer's and dozens of others — could be fixed this way.
But the process, which is often set in motion
by cells of the immune system, can also occur whenever
tissue is
damaged — even in the absence of a pathogenic organism — as, for example, when you stub your toe or, more seriously, suffer a
heart attack.
Scientists at the Bar Harbor - based MDI Biological Laboratory have been awarded a patent — the first for the lab — for MSI - 1436, a potential new
heart disease drug that stimulates the repair and regeneration of
heart tissue damaged by injuries and
heart attacks.
By stimulating the growth of new blood vessels, promoting anti-inflammatory effects, recruiting cells toward
tissue regeneration and inhibiting further cell death, adult stem cells can restore some function to
damaged or diseased
heart muscle.
Okyanos cardiac cell therapy targets the restoration of blood flow to the
heart and repairs
damaged heart tissue caused
by heart attack or ischemic and non-ischemic
heart disease.
The U.S. Patent and Trademark Office has announced that it will grant a patent to MDI Biological Laboratory scientists Voot P. Yin, Ph.D., and Kevin Strange, Ph.D., and their collaborator Michael Zasloff, M.D., Ph.D., for use of the small molecule MSI - 1436 to stimulate the repair and regeneration of
heart tissue damaged by injuries such as a
heart attack.
These penetrate
tissue and heat up when excited
by radio - frequency waves; and they have been shown to thaw arteries and
heart valve
tissue from pigs, as well as human skin cells, rapidly and evenly, without the typical
damage.
But
heart cells never truly regenerate in the
damaged tissue, and myofibroblasts compensate for their absence
by forming a stiff, collagenous scar that interferes with the
heart's ability to maintain stable
heart rhythms and to expand and contract forcefully to pump blood.
CINCINNATI - Scientists used an experimental targeted molecular therapy to block a matrix - forming protein in
heart cells
damaged by heart attack, reducing levels of scarred muscle
tissue and saving mouse models from
heart failure.
By studying them, we are beginning to gain insight into human disease — to understand why organs such as the
heart can not repair themselves or why, as we age, the incidence of debilitating diseases such as cancer,
heart disease and Alzheimer's increases so rapidly, and we are developing new therapies that will enhance our abilities to regenerate
damaged tissues and prolong healthy lifespan.
But now, scientists at the Gladstone Institutes have demonstrated that this
damage need not be permanent —
by finding a way to transform the class of cells that form human scar
tissue into those that closely resemble beating
heart cells.
It, simultaneously, stimulates circulation to the
heart tissues, thereby helping to prevent the
damage caused
by high blood pressure.
Although this spring seems to be having some difficulty kicking into any warming trend, heartworm disease is very serious and can cause
damage to the
heart tissue and even death; don't take any chances
by delaying prevention.
ACT - activated clotting time (bleeding disorders) ACTH - adrenocorticotropic hormone (adrenal gland function) Ag - antigen test for proteins specific to a disease causing organism or virus Alb - albumin (liver, kidney and intestinal disorders) Alk - Phos, ALP alkaline phosphatase (liver and adrenal disorders) Allergy Testing intradermal or blood antibody test for allergen hypersensitivity ALT - alanine aminotransferase (liver disorder) Amyl - amylase enzyme — non specific (pancreatitis) ANA - antinuclear antibody (systemic lupus erythematosus) Anaplasmosis Anaplasma spp. (tick - borne rickettsial disease) APTT - activated partial thromboplastin time (blood clotting ability) AST - aspartate aminotransferase (muscle and liver disorders) Band band cell — type of white blood cell Baso basophil — type of white blood cell Bile Acids digestive acids produced in the liver and stored in the gall bladder (liver function) Bili bilirubin (bile pigment responsible for jaundice from liver disease or RBC destruction) BP - blood pressure measurement BUN - blood urea nitrogen (kidney and liver function) Bx biopsy C & S aerobic / anaerobic bacterial culture and antibiotic sensitivity test (infection, drug selection) Ca +2 calcium ion — unbound calcium (parathyroid gland function) CBC - complete blood count (all circulating cells) Chol cholesterol (liver, thyroid disorders) CK, CPK creatine [phospho] kinase (muscle disease,
heart disease) Cl - chloride ion — unbound chloride (hydration, blood pH) CO2 - carbon dioxide (blood pH) Contrast Radiograph x-ray image using injected radiopaque contrast media Cortisol hormone produced
by the adrenal glands (adrenal gland function) Coomb's anti- red blood cell antibody test (immune - mediated hemolytic anemia) Crea creatinine (kidney function) CRT - capillary refill time (blood pressure,
tissue perfusion) DTM - dermatophyte test medium (ringworm — dermatophytosis) EEG - electroencephalogram (brain function, epilepsy) Ehrlichia Ehrlichia spp. (tick - borne rickettsial disease) EKG, ECG - electrok [c] ardiogram (electrical
heart activity,
heart arryhthmia) Eos eosinophil — type of white blood cell Fecal, flotation, direct intestinal parasite exam FeLV Feline Leukemia Virus test FIA Feline Infectious Anemia: aka Feline Hemotrophic Mycoplasma, Haemobartonella felis test FIV Feline Immunodeficiency Virus test Fluorescein Stain fluorescein stain uptake of cornea (corneal ulceration) fT4, fT4ed, freeT4ed thyroxine hormone unbound
by protein measured
by equilibrium dialysis (thyroid function) GGT gamma - glutamyltranferase (liver disorders) Glob globulin (liver, immune system) Glu blood or urine glucose (diabetes mellitus) Gran granulocytes — subgroup of white blood cells Hb, Hgb hemoglobin — iron rich protein bound to red blood cells that carries oxygen (anemia, red cell mass) HCO3 - bicarbonate ion (blood pH) HCT, PCV, MHCT hematocrit, packed - cell volume, microhematocrit (hemoconcentration, dehydration, anemia) K + potassium ion — unbound potassium (kidney disorders, adrenal gland disorders) Lipa lipase enzyme — non specific (pancreatitis) LYME Borrelia spp. (tick - borne rickettsial disease) Lymph lymphocyte — type of white blood cell MCHC mean corpuscular hemoglobin concentration (anemia, iron deficiency) MCV mean corpuscular volume — average red cell size (anemia, iron deficiency) Mg +2 magnesium ion — unbound magnesium (diabetes, parathyroid function, malnutrition) MHCT, HCT, PCV microhematocrit, hematocrit, packed - cell volume (hemoconcentration, dehydration, anemia) MIC minimum inhibitory concentration — part of the C&S that determines antimicrobial selection Mono monocyte — type of white blood cell MRI magnetic resonance imaging (advanced
tissue imaging) Na + sodium ion — unbound sodium (dehydration, adrenal gland disease) nRBC nucleated red blood cell — immature red blood cell (bone marrow
damage, lead toxicity) PCV, HCT, MHCT packed - cell volume, hematocrit, microhematocrit (hemoconcentration, dehydration, anemia) PE physical examination pH urine pH (urinary tract infection, urolithiasis) Phos phosphorus (kidney disorders, ketoacidosis, parathyroid function) PLI pancreatic lipase immunoreactivity (pancreatitis) PLT platelet — cells involved in clotting (bleeding disorders) PT prothrombin time (bleeding disorders) PTH parathyroid hormone, parathormone (parathyroid function) Radiograph x-ray image RBC red blood cell count (anemia) REL Rocky Mountain Spotted Fever / Ehrlichia / Lyme combination test Retic reticulocyte — immature red blood cell (regenerative vs. non-regenerative anemia) RMSF Rocky Mountain Spotted Fever SAP serum alkaline phosphatase (liver disorders) Schirmer Tear Test tear production test (keratoconjunctivitis sicca — dry eye,) Seg segmented neutrophil — type of white blood cell USG Urine specific gravity (urine concentration, kidney function) spec cPL specific canine pancreatic lipase (pancreatitis)-- replaces the PLI test spec fPL specific feline pancreatic lipase (pancreatitis)-- replaces the PLI test T4 thyroxine hormone — total (thyroid gland function) TLI trypsin - like immunoreactivity (exocrine pancreatic insufficiency) TP total protein (hydration, liver disorders) TPR temperature / pulse / respirations (physical exam vital signs) Trig triglycerides (fat metabolism, liver disorders) TSH thyroid stimulating hormone (thyroid gland function) UA urinalysis (kidney function, urinary tract infection, diabetes) Urine Cortisol - Crea Ratio urine cortisol - creatine ratio (screening test for adrenal gland disease) Urine Protein - Crea Ratio urine protein - creatinine ratio (kidney disorders) VWF VonWillebrands factor (bleeding disorder) WBC white blood cell count (infection, inflammation, bone marrow suppression)