Sentences with phrase «by decreasing levels»

What this means is that Hypocretin Neuron activity is stimulated in part by decreasing levels of leptin in the blood, and that increased leptin levels reduce the level of excitation running through Hypocretin Neurons.

Rhonda Patrick, PHD writes «cold exposures increase cold shock proteins including one in the brain that repairs damaged synapses and in muscle prevents atrophy, how cold - induced norepinephrine lowers inflammation and pain by decreasing the levels of 3 inflammatory mediators...» * [9] This is very, very interesting stuff and it's grounded in evolutionary science.

Rhonda Patrick, PHD writes «cold exposures increase cold shock proteins including one in the brain that repairs damaged synapses and in muscle prevents atrophy, how a cold - induced catecholamine lowers inflammation and pain by decreasing the levels of 3 inflammatory mediators...» [10] This is very, very interesting stuff and it's grounded in evolutionary science.

Now research has documented that Holy Basil may do this by decreasing levels of cortisol, a hormone produced and secreted by the adrenal glands.

Menstrual irregularity is most common in a woman in her mid-40's as she approaches menopause; the most likely cause of this is hormonal imbalance caused by decreasing levels of estrogen and progesterone.

The drug also appeared to reduce the amount of the protein amyloid beta (which forms toxic plaques in the brains of Alzheimer's patients) by decreasing the levels of metals such as zinc and copper.

While expression levels of all marker genes remained almost unchanged in wild - type ACVR1 cultures compared with the empty viral vector, the expression profile induced by caACVR1 Q207D displayed evidence of advanced chondrogenic differentiation as shown by decreased levels of the early differentiation stage marker collagen type II together with enhanced expression of the later - stage markers Ihh and collagen type X. Indian hedgehog has been shown previously to be induced by BMP signaling transmitted via the ACVR1 receptor (9).

It is caused by decreased levels of the alpha - 1 antitrypsin (AAT) protein.

Hypothyroidism can increase testosterone by decreasing the level of sex hormone binding globulin (SHBG), increasing the conversion of androstenedione to testosterone and estradiol, and reducing the metabolic clearance of androstenedione (1,5).

Not exact matches

The decreases in individual tax rates, on the other hand, are smaller and less certain, with rates set to revert back to current levels by 2026.

The goal was to decrease emissions to 17 % below 2005 levels in 2020 and 26 - 28 % by 2025.

But just 20 minutes of low - to - moderate intensity exercise (like walking) performed three times a week can increase energy levels by 20 percent and decrease fatigue by 65 percent, according to a University of Georgia study.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

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Overall working capital decreased by 3.9 % versus a year ago, primarily due to lower inventory levels, and accounts receivable decreased by 11.7 %.

Examples of these risks, uncertainties and other factors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.

Results of the study showed that the total antioxidant capacity in the bloodstream of the participants increased, and that their level of oxidative stress (as measured by the amount of carboxymethyllysine in their blood serum) decreased.

Soaking of millet, soya bean, maize, sorghum, and mung bean at 92 degrees F for 24 hours decreased the contents of phytic acid by 4 — 51 percent.43 With these same grains and beans, soaking at room temperature for 24 hours reduced phytic acid levels by 16 — 21 percent.44 However, soaking of pounded maize for one hour at room temperature already led to a reduction of phytic acid by 51 percent.45

Brazil Segment revenue was negatively impacted by a decrease in bran processing levels as well as a 12 % quarter over quarter decline in the average Brazilian Real versus US Dollar exchange rate.

A low - carbohydrate diet can aid in weight loss and weight maintenance by decreasing insulin levels, which causes the body to burn stored fat for energy.

Of course, the heat level can be adjusted by varying the number habaneros used, by increasing the amounts of the other ingredients in the recipes, or by removing the seeds and placental tissue to decrease the heat of the habaneros.

Though many of my recipes can be replicated at sea level, if you find that a recipe isn't turning out, decrease the flour by 2 tablespoons per cup, decrease the liquid by 1 tablespoon per cup, and keep in mind that baked goods may take a few minutes longer to bake through.

Taste the result and adjust the flavors by adding more triple sec to make it sweeter, more lime juice to make it more tart, more tequila to increase the heat level, or more ice to decrease the heat level.

The cryotherapy process reduces inflammation for pain relief and improved mobility by decreasing the cellular metabolism, pain and spasm while increasing cellular survival and the levels of oxygenated blood delivered to damaged tissue.

By omitting home teams, there isn't much of a drop - off in units won at each betting percentage level, but we once again decrease the number of wagers needed to achieve those results, improving our ROI even further.

This stage represents the final effect of the event on the clinician, who may leave the clinical profession altogether, stay in her previous role but never function at her previous performance level, or thrive by taking lessons learned and working to ensure that deficits in the process led to the outcome are addressed in effort to decrease the likelihood that such an event will occur.

To lose about a pound a week, cut out 500 calories a day either by decreasing your food intake or increasing your activity level.

Low amniotic fluid is more common when women go past their due date because the fluid level decreases by close to half by the 42nd week, but it can also be associated with fetal abnormalities and birth defects if low fluid is detected during the first or second trimesters.

They found that exercise may help cognition by increasing blood and oxygen to the brain, increasing levels of norepinephrine, and endorphins to decrease stress and improve mood, and increasing growth factors that help create new nerve cells and support synaptic plasticity.

Crime dropped overall by one - fourth of one percent in 2013, McCarthy said, acknowledging «that may not sound like much,» but then he quickly mentioned the 16 percent decrease in 2012 from 2011 levels.

If a woman is past her due date by two weeks or more, she may be at risk for low amniotic fluid levels since fluids can decrease by half once she reaches 42 weeks gestation.

Breastfeeding may decrease the risk of cardiovascular disease in later life, as indicated by lower cholesterol and C - reactive protein levels in breastfed adult women.

An average adult decreases blood alcohol levels by 15 to 20 mg / dL / hour.

About 95 minutes after smoking, the level of nicotine in the mother's blood and milk has decreased by about half.

During this time, there is a steady decrease in blood calcium levels, and some women have had success stabilizing their supply by adding a calcium / magnesium supplement to their diet during this time.

Interestingly, the level of prolactin increases or decreases with the amount of milk needed by the baby and the mother's fertility responds easily to this very sensitive system.

Mothers experienced decreased salivary cortisol levels (by 32 percent), decreased heart rate (by 7 percent), decreased VAS score (by 89 percent), and increased mood (by 6 percent).

It can be used to calm a colicky baby by reducing stress, deepen the bond with parent by releasing the hormone oxytocin (the feel good hormone) and decreasing the levels of cortisol (the stress hormone) in both the baby and caregiver.

The most recent study report described in these same regions decreased tissue levels of 5 - HT and tryptophan hydroxylase, the synthesizing enzyme for serotonin, and no evidence of excessive serotonin degradation as assessed by levels of 5 - hydroxyindoleacetic acid (the main metabolite of serotonin) or ratios of 5 - hydroxyindoleacetic acid to serotonin.30 A recent article described a significant association between a decrease in medullary 5 - HT1A receptor immunoreactivity and specific SIDS risk factors, including tobacco smoking.40 These data confirm results from earlier studies in humans39, 41 and are also consistent with studies in piglets that revealed that postnatal exposure to nicotine decreases medullary 5 - HT1A receptor immunoreactivity.42 Animal studies have revealed that serotonergic neurons located in the medullary raphe and adjacent paragigantocellularis lateralis play important roles in many autonomic functions including the control of respiration, blood pressure, heart rate, thermoregulation, sleep and arousal, and upper airway patency.

But I have to disagree on one point: The case that equality does not just benefit the poor but decreases a whole host of social problems and is even of benefit to the wealthy has been comprehensively made by Richard Wilkinson and Kate Pickett in their book The Spirit Level.

The case that equality does not just benefit the poor but decreases a whole host of social problems and is even of benefit to the wealthy has been comprehensively made by Richard Wilkinson and Kate Pickett in their book The Spirit Level.

The passed budget decreases the tax levy by 0.15 percent while still maintaining a high level of academics and support for students.

She said that as long as exposure does not continue, PFOA levels in adults decrease by half every three years.

The National Science Foundation (NSF) budget would decrease by a total $ 819 million or 11 percent below last year's omnibus levels.

For example, with UK targets demanding a 34 per cent decrease in carbon emissions compared to 1990 levels by 2020, companies are increasingly required to change the way they do business, says Som Narayan, co-founder of Carbon Masters, an Edinburgh - based company which helps organisations reduce their carbon emissions.

City of Dallas Texas Government 334 million green kWh, 40 % of total power used After hosting an eye - opening climate conference, the city government decided to help lower statewide ozone levels by decreasing its conventional power use, says Jill Jordan, an assistant city manager.

According to figures from the World Bank, the Chinese economy's carbon intensity — the amount of CO2 emissions relative to the size of economic output — has decreased by almost 70 per cent over the past three decades (see «Peak planet: Carbon dioxide intensity «-RRB-, and a further 20 per cent reduction from current levels is promised by 2020.

Taken together, the research data provides a picture, from the leaf scale to the global scale, suggesting that droughts in the Amazon basin are affecting levels of carbon dioxide in the atmosphere globally, both on a short - term basis though decreasing photosynthesis and on a longer term basis, by increasing tree mortality.

Animal studies suggest ingestion of pesticide mixtures in early pregnancy may be associated with decreased live - born offspring leading to concerns that levels of pesticide residues permitted in food by the U.S. Environmental Protection Agency may still be too high for pregnant women and infants.

The walnut - rich diet had the most impact on cholesterol levels by decreasing low - density lipoprotein (LDL), or bad cholesterol, and increasing beneficial high - density lipoprotein (HDL).