Sentences with phrase «by decreasing their expression»

By decreasing the expression of CerS4 in these mice, the Ogretmen laboratory hopes to better define the way in which CerS4 regulates cell migration and metastasis.

The log10 FPKM +1 values from the RNAseq data are plotted in blue, and genes are ordered by decreasing expression level.

Flavonoids, including anthocyanins, seem to modulate this type of monocyte adhesion during the inflammatory process by decreasing their expression by endothelial cells.

Not exact matches

One should not in this connection let himself be deceived by the observation that the abstract thinking of the Greeks made it possible for them to understand in its purity the essence of the spiritual, and that therefore mythological, anthropomorphic ideas of God were abandoned by the Greeks, while in Judaism naïve mythological and anthropomorphic expressions about God, although they decrease, do not by any means disappear.

Religious programs act as a functional alternative to the local church, thus decreasing attendance and involvement by reinforcing the social tendency toward the individualizing of religious experience at the expense of its corporate expressions, and placing a burden on the religious broadcasting organizations which they are not equipped to handle.

Results showed that BPA exposure permanently affected the uterus by decreasing regulation of gene expression.

By blocking the expression of a certain gene in patients, University of Montreal researchers have contributed to the demonstration of great decreases in the concentration of triglycerides in their blood, even in various severe forms of hypertriglyceridemia and regardless of the base values or the treatment the patient usually receives.

This chimera, created by a team at the Georgia Cancer Center, has the ability to simultaneously decrease the expression of three growth factors that are over-expressed in some cancers.

Suppression of tumor growth by terbinafine is associated with decreased cholesteryl ester concentrations, restoration of PTEN expression, and inhibition of AKT - mTOR, consistent with blockade of SQLE function.

Importantly, patients with mutations in a single copy of NKX2.1 often have Brain - Lung - Thyroid Syndrome, which is characterized by respiratory distress after birth and accompanied by decreased surfactant protein expression.

Knockdown of LL34 expression leads to decreased retinoic acid signaling, suggesting that this lncRNA may play an early role in the development of the lung, as well as other tissues controlled by this pathway.

Additionally, protein degradation was repressed by a 6 °C decrease in body temperature and an increase in expression of alpha -2-macroglobulin, a broadly acting protease inhibitor.

While expression levels of all marker genes remained almost unchanged in wild - type ACVR1 cultures compared with the empty viral vector, the expression profile induced by caACVR1 Q207D displayed evidence of advanced chondrogenic differentiation as shown by decreased levels of the early differentiation stage marker collagen type II together with enhanced expression of the later - stage markers Ihh and collagen type X. Indian hedgehog has been shown previously to be induced by BMP signaling transmitted via the ACVR1 receptor (9).

Loss of tumor suppressor p53 decreases PTEN expression and enhances signaling pathways leading to activation of activator protein 1 and nuclear factor kappaB induced by UV radiation.

Analyses were performed with 5 animals per group (control, 3 h of hypoxia, and 24 h or recovery after 3 h hypoxia) to decrease bias that may be introduced by donor - specific gene expression patterns.

Stress sensitive female macaques have decreased fifth Ewing variant (Fev) and serotonin - related gene expression that is not reversed by citalopram.

Immunoblots showed almost complete inhibition of mTOR expression (as shown in Fig. 4B) that resulted in decreased cell proliferation as assessed by MTS assay (A).

Cell cycle studies also showed that inhibition of mTOR function by using rapamycin or inhibition of mTOR expression by using mTOR - specific siRNA induced cell cycle arrest as shown by a dose - dependent decrease of cell cycle S phase (data not shown).

During the multistep process of carcinogenesis, decreased expression of tumor suppressors is often caused by epigenetic modification or abnormal degradation (48, 49).

When TLRs are triggered by lipopolysaccharides, oral Langerhans cells upregulate expression of coinhibitory molecules B7 - H1 and B7 - H3, whereas expression of the costimulatory molecule CD86 (B7 - 2) is decreased.

Alpha tubulin is not suitable as a loading control in adipose tissue as expression of tubulin in adipose tissue is very low (Spiegelman and Farmer, Cell, 1982, 29 (1): 53 - 60, «in cells undergoing adipose differentiation actin synthesis decreases by 90 %»).

Inversely, almost complete inhibition of AKT1 gene expression by AKT1 - specific siRNA resulted in decreased p - mTOR levels (Fig. 3C).

The increase in the Aβ42 / Aβ40 ratio (driven by a decrease in plasma Aβ40 levels) could also be related to the observed decrease in expression of CLU as part of the relaxation effect (P = 0.00045).

PEGylated arginine deiminase can modulate tumor immune microenvironment by affecting immune checkpoint expression, decreasing regulatory T cell accumulation and inducing tumor T cell infiltration.

Silencing of total mTOR gene expression by siRNA decreased AKT phosphorylation.

We found that depletion of ABL kinases in breast cancer cells decreased STAT5A mRNA expression (Fig. 6D) without decreasing total STAT5 protein abundance as measured by Western blotting with antibodies that detect both STAT5A and STAT5B (Fig. 7D and fig.

CCHa2 expression was decreased by starvation and recovered by re-feeding the starved larvae with yeast paste.

These techniques and functional analysis of the resulting data revealed a number of up - and down - regulated proteins and mRNAs; i.e., up - regulated by a signal (originating internal or external to the cell) that results in increased expression of one or more genes and as a result the protein (s) encoded by those genes, and down - regulated by a process resulting in decreased gene and corresponding protein expression.

ActD - induced p53 - expression significantly decreased when AKT expression was knocked - down by shRNA.

Depletion of ABL kinases in breast cancer cells decreased IL - 6 concentrations and was accompanied by increased OPG expression in osteoblasts.

These increases were accompanied by disruption of tight junctions and a decrease in expression of the tight junction protein occludin.

Fluoranthene enhances p53 expression and decreases mutagenesis induced by benzo [a] pyrene.

When AKT was downregulated by small hairpin RNA - AKTs, ActD - induced p53 expression was significantly decreased.

PRDM14 and DAZL were expressed in ES cells, but this expression in the EBs decreased by day 21 and 14, respectively.

PTC's GEMS technology exploits the regulatory mechanisms found in the untranslated regions of messenger RNA for the identification of small - molecule drugs that can treat diseases by selectively increasing or decreasing the expression of key proteins by modulating post-transcriptional mechanisms.

Interestingly, BDNF expression was found to be regulated by FNDC5 in a cell - autonomous manner, and recombinant BDNF treatment led to the decreased expression of FNDC5 as part of a negative feedback loop.

Here, we hypothesize that XJB -5-131 will lower IOP by decreasing endogenous TGF - Î ² 2 gene expression and protein secretion.

Following aggregate plating and Ara - C addition, Oct4 protein expression progressively decreased, disappearing by day twelve.

In young animals, immunological activation drives a conserved transcriptomic switch, resulting in tightly controlled gene expression characterized by a strong up - regulation of a core activation program, coupled with a decrease in cell - to - cell variability.

Furthermore, movement - independent ZENK expression in the forebrain of night - migratory birds performing magnetic orientation at night is confined to Cluster N [with the strongest activation in distinct subregions (the shell surrounding the DNH nucleus)-RSB-, as shown by the detailed quantification of ZENK expression within Cluster N performed in this study], and this expression massively decreased in corresponding brain areas of non-migratory songbirds and in all bird species during daytime [13].

Consistent with the demonstration that LARP7 is necessary for the integrity of the 7SK snRNA (He et al., 2008), the reduced LARP7 expression in invasive breast cancer cell lines was accompanied by a decrease in 7SK snRNA (Figure 1D).

With my doctor's guidance, I discovered I could influence the expression of the TTR gene, and consequently decrease my pain, simply by changing my environment and lifestyle.

Despite this possibility, mevinolin, the active ingredient in red yeast rice, is capable of reducing 7 - dehydrocholesterol levels, 22 and simvistatin (Zocor) not only inhibits the synthesis of mevalonate but also enhances the conversion of 7 - dehydrocholesterol to cholesterol by increasing the expression of 7 - DHCR.23 Simvistatin thereby hits the pool of 7 - dehydrocholesterol with a double - whammy, both decreasing its synthesis and increasing its degradation.

The theory proposed by Professor Khavinson is based on the underlying assumption that changes in gene expression result in decreased protein synthesis, eventually leading to aging and the development of diseases.

• Tang - kuei (Bai Zhi, Radix Angelicae Dahurica) Tang - kuei has been shown to modulate inflammation by decreasing leukocyte counts, neutrophil density, and interleukin - 6 (IL - 6) expression.

In rodent models of T1D induced by streptozotocin, it was found that THC mitigated the severity of the immune response, transiently prevented hyperglycemia and loss of pancreatic insulin, and decreased expression of pro-inflammatory elements including CD3 + T cells, IL - 12, IFN - γ and TNF - α (50).

While acute THC stimulates appetite, the repeated stimulation of CB1 receptors by THC decreases receptor expression and sensitivity, and long - term stimulation may result in antagonistic rather than agonistic triggering of CB1 receptors, which would dampen hunger signals.

Diabetes Care: «Monounsaturated fat - rich diet prevents central body fat distribution and decreases postprandial adiponectin expression induced by a carbohydrate - rich diet in insulin - resistant subjects.»

Studies showed that curcumin reduced joint swelling by modifying gene expression; inhibited inflammation by regulating NF - κB, a pro-inflammatory protein; and slowed down joint destruction by decreasing activity of osteoblasts, cells involved in bone breakdown.

The minor allele of rs25532 significantly decreased luciferase reporter gene expression levels by 15 — 80 %, depending on 5 - HTTLPR allele background and cell type.