Sentences with phrase «by different factors in»

Not exact matches

These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.

Any such statement may be influenced by a variety of factors, many of which are beyond the control of Oracle or Vocado, that could cause actual outcomes and results to be materially different from those projected, described, expressed or implied in this document due to a number of risks and uncertainties.

Actual results, including with respect to our targets and prospects, could differ materially due to a number of factors, including the risk that we may not obtain sufficient orders to achieve our targeted revenues; price competition in key markets; the risk that we or our channel partners are not able to develop and expand customer bases and accurately anticipate demand from end customers, which can result in increased inventory and reduced orders as we experience wide fluctuations in supply and demand; the risk that our commercial Lighting Products results will continue to suffer if new issues arise regarding issues related to product quality for this business; the risk that we may experience production difficulties that preclude us from shipping sufficient quantities to meet customer orders or that result in higher production costs and lower margins; our ability to lower costs; the risk that our results will suffer if we are unable to balance fluctuations in customer demand and capacity, including bringing on additional capacity on a timely basis to meet customer demand; the risk that longer manufacturing lead times may cause customers to fulfill their orders with a competitor's products instead; the risk that the economic and political uncertainty caused by the proposed tariffs by the United States on Chinese goods, and any corresponding Chinese tariffs in response, may negatively impact demand for our products; product mix; risks associated with the ramp - up of production of our new products, and our entry into new business channels different from those in which we have historically operated; the risk that customers do not maintain their favorable perception of our brand and products, resulting in lower demand for our products; the risk that our products fail to perform or fail to meet customer requirements or expectations, resulting in significant additional costs, including costs associated with warranty returns or the potential recall of our products; ongoing uncertainty in global economic conditions, infrastructure development or customer demand that could negatively affect product demand, collectability of receivables and other related matters as consumers and businesses may defer purchases or payments, or default on payments; risks resulting from the concentration of our business among few customers, including the risk that customers may reduce or cancel orders or fail to honor purchase commitments; the risk that we are not able to enter into acceptable contractual arrangements with the significant customers of the acquired Infineon RF Power business or otherwise not fully realize anticipated benefits of the transaction; the risk that retail customers may alter promotional pricing, increase promotion of a competitor's products over our products or reduce their inventory levels, all of which could negatively affect product demand; the risk that our investments may experience periods of significant stock price volatility causing us to recognize fair value losses on our investment; the risk posed by managing an increasingly complex supply chain that has the ability to supply a sufficient quantity of raw materials, subsystems and finished products with the required specifications and quality; the risk we may be required to record a significant charge to earnings if our goodwill or amortizable assets become impaired; risks relating to confidential information theft or misuse, including through cyber-attacks or cyber intrusion; our ability to complete development and commercialization of products under development, such as our pipeline of Wolfspeed products, improved LED chips, LED components, and LED lighting products risks related to our multi-year warranty periods for LED lighting products; risks associated with acquisitions, divestitures, joint ventures or investments generally; the rapid development of new technology and competing products that may impair demand or render our products obsolete; the potential lack of customer acceptance for our products; risks associated with ongoing litigation; and other factors discussed in our filings with the Securities and Exchange Commission (SEC), including our report on Form 10 - K for the fiscal year ended June 25, 2017, and subsequent reports filed with the SEC.

«How we behave in relation to altruism and giving is shaped by a lot of different factors,» said study co-author Sarah Smith of the University of Bristol.

Technically speaking, the research shows that differences in the so - called Big Five personality traits in regions with different climates can't be explained by other factors.

The fact that official purchases of financial assets are determined by different factors than those influencing private investors suggests that we would probably see a somewhat different combination of capital flows, exchange rates and interest rates in the absence of official intervention.

Historically, different combinations of valuation, market action and other factors have been accompanied by significantly different bond market performance in terms of return / risk.

CenterSquare aims to uncover low relative price opportunities across sectors and at different turning points in the real estate cycle by looking beyond the obvious factors of stock price and underlying real estate value.

Examples of these risks, uncertainties and other factors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commfactors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commfactors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commfactors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange CommFactors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.

Historically, different combinations of valuation, market action and other factors have been accompanied by significantly different stock market performance in terms of return / risk.

In advancing these theories they disregard factors universally admitted by all scientists — that in the initial period of the «birth» of the universe, conditions of temperature, atmospheric pressure, radioactivity, and a host of other catalytic factors were totally different than those existing presently, including the fact that we don't know how single atoms or their components would bind and consolidate, which involved totally unknown processes and variables, as single atoms behave far differently than conglomerations of atomIn advancing these theories they disregard factors universally admitted by all scientists — that in the initial period of the «birth» of the universe, conditions of temperature, atmospheric pressure, radioactivity, and a host of other catalytic factors were totally different than those existing presently, including the fact that we don't know how single atoms or their components would bind and consolidate, which involved totally unknown processes and variables, as single atoms behave far differently than conglomerations of atomin the initial period of the «birth» of the universe, conditions of temperature, atmospheric pressure, radioactivity, and a host of other catalytic factors were totally different than those existing presently, including the fact that we don't know how single atoms or their components would bind and consolidate, which involved totally unknown processes and variables, as single atoms behave far differently than conglomerations of atoms.

Contrary to long - entrenched expectations, we witness a world in which different civilizations — defined by different cultures that are typically defined, in turn, by cult or religion — are the deciding factor in collective allegiances and conflicts.

It may be an arrangement that factors out different aspects of the school's common life to the reign of each model of excellent schooling: the research university model may reign for faculty, for example, or for faculty in certain fields (say, church history, or biblical studies) but not in others (say, practical theology), while paideia reigns as the model for students, or only for students with a declared vocation to ordained ministry (so that other students aspiring to graduate school are free to attempt to meet standards set by the research university model); or research university values may be celebrated in relation to the school's official «academic» program, including both classroom expectations and the selection and rewarding of faculty, while the school's extracurricular life is shaped by commitments coming from the model provided by paideia so that, for example, common worship is made central to their common life and a high premium is placed on the school being a residential community.

If people think the initial vision of Whitehead, which reveals such a different vision of nature as given to us in bare sense - awareness, ought to be explored — and if it is explored you get a very new, very wide set of possibilities for science — then one ought to start by flying to find out what his units of the passage of nature are — namely these «factors» which he also calls durations.

2) blood type has nothing to do with how the child develops, outside the odd occurance of the RH factors being different and the mother's body (created by god according to you) attempts to abort the foriegn body (fetus) because it doesn't blend in with the mother's defence systems.

The value of Spain's wine rose 8.9 %, with volumes flat at 0.1 %, fed by a number of different factor: although bulk wine volume fell in value as the price per litre rose «significantly», this was offset by value sales rising 11 % and there was an improvement in PDO wine exports which make up around 16 % of sales.

The country briefly achieved rice self - sufficiency in the 1970s, but was set back by different factors such as its location in the typhoon belt, limited land, and high population increase in succeeding decades.

So we are looking at 7 games and projecting that to a 7 game series, which would be equivalent to me telling that auto dealership that their 2017 May auto sales would be similar to the 2018 May auto sales, when in fact those numbers could have been manipulated by a large number of factors (weather, auto pricing, the local economy at the time, maybe dealership construction) just like Turners numbers may be manipulated (Injury, fatigue, Offense being built to go thru a different player that game)

your emotions are darkening your view, to be the best, you need someone to tell you why, everyone can earn money, and players are proving that, even if they lose they get paid, but go to your job and do nt work 100 %, boss would fire you, cuz he is motivated by profit, in sport things are different, you get paid no matter what, so motivation is big factor, like it or not!!!

Depression in teens can be caused by different factors: a tragic event in the teen's life, a genetic predisposition to depression, or social out - casting by the teen's peers to name a few.

Add to the mix additional siblings of the ADHD child and conflicts, attention pulled in different directions, feelings of resentment by the child who requires less attention --- all these factors combine to create a parenting role that can quickly become overwhelming.

The different trends in fathering can be explained by cultural, social, and financial factors.

Mother in law wanted to choose a different name for her child (husband had a row with his mother over this and used the guilt factor to getting her way) and practically had Joan follow her step by step instructions on how to care for her child.

Restless sleeping in babies is caused by many different factors.

Another approach which is used in U.S. state and local taxation by virtue of an interstate compact, is to have entities (or consolidated groups of corporations) prepare one tax return for the entire world and then to allocate pro-rata percentages of that global return to different jurisdictions based upon a handful of factors that are relatively hard to manipulate and bear a meaningful relationship to where income is earned such as sales, employment and the location of physical assets.

To address this, the research funded by the Economic and Social Research Council (ESRC), led by Professor Charles Alderson at Lancaster University, set out to identify the factors that determine how this skill develops in a number of different languages and what factors in people's first language influence progress in reading.

In short — the factors motivating Leave voters are many and varied and 52 % of the voters will, by definition, contain people with many, many different views and priorities.

The guidelines, published January 5 in the Journal of Allergy and Clinical Immunology and five other journals, include pages of detailed advice and group kids by different risk factors.

Although identical twins have the same genes as each other, their epigenomes — the collection of methyl marks studding their DNA — are different by the time they reach adulthood due in part to environmental factors.

By extending the equation to allow it to reproduce the effects of variable weather and seasons, and to consider sheep in different age groups, the team was able to pin down the key factors affecting their size.

In contrast, the Majoranas have different phase factors, so you only go back to your old state by switching four times, instead of two.

Another complicating factor making present climate change different from events in the past is that most ecosystems are now dominated by human use, making it harder for species to adjust their geographic ranges in response to the changing climate.

Vrijenhoek and his collaborators are trying to figure out if the different vent communities in the Gulf are controlled by differences in water depth, geochemistry, symbiotic bacteria, or perhaps other unanticipated factors.

Heritability (how much the risk of a disease is explained by genetic factors) of type 2 diabetes has been estimated to be between 25 and 80 per cent in different studies.

Diamond acknowledges that many other factors are involved in the long history of this island but that the comparative method, he writes, consists of comparing — preferably quantitatively and aided by statistical analyses — different systems that are similar in many respects but that differ with respect to the factors whose influence one wishes to study.

The readability of genes is controlled by epigenetic factors, namely factors which do not influence the gene sequence directly, but rather cause certain genes and chromosomal segments to be packed in different densities — and thus make them accessible for reading.

By functionally linking the signal transduction of melanopsin to the control circuit of the nuclear factor of activated T cells, we have designed a synthetic signaling cascade enabling light - inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice.

After analysing the presence of NANOG in different mouse tissues by immunohistochemistry, the CNIO team demonstrated that, in addition to being present in embryonic tissue, this factor is also found in stratified epithelia such as the esophagus, skin or vagina.

«The reason we see them as different is that we factor in the obvious shadow being cast by the cylinder, blocking the source of light pouring in from the upper right.

«Studies like ours can help those working with these patients: awareness of the roles played by the different factors is in fact crucial for devising interventions aiming to minimise the effect of the deficits and restore normal weight levels in individuals who are already suffering because of the disease.»

Per Jensen points out that the study shows how social behaviour is to a large extent controlled by the same genetic factors in different species.

Indeed, using different official sources of activity data and emissions factors can result in estimates that vary by up to 40 per cent in a given year.

Genetic factors are clearly indicated as evidenced by dominant mutations in three different genes have been identified that account for the small number of cases of familial, early - onset AD.

«Atopic dermatitis and psoriasis are two distinct diseases that are induced by alternate immune responses and the factors involved are quite different,» explains Michael Croft, Ph.D., professor and head in the Division of Immune Regulation, who led the research.

Constant cascade One researcher might have worked out a way to avoid the inhibitor issue almost entirely, by developing a different molecule to take the place of factor VIII in the clotting cascade.

Disregarding the problem of disguises, face - recognition programs can be thrown off by factors such as changes in hair and facial hair, different expressions, and aging.

The types of tumor that can be particularly responsive to immunotherapy generally happen in older people, or people who have genetic factors that allow their tumors to acquire a lot of mutations — so that the tumor has a lot of different antigens that are recognized by the immunotherapy.

Ruffled genes Burke was part of a team that, in 1995, found that the different approaches of male ruffs were caused by a single inherited factor.

Myriad control switches help to arbitrate how genes get expressed in different cells and tissues, and those switches are often triggered by maternal diet, toxic exposures and many other environmental factors.

«We wanted to learn more about how the brain is different in Down Syndrome compared to typical development, so we measured surface area and thickness, which both contribute to cortical volume but are determined by different genetic factors.»