Sentences with phrase «by disease stage»

The timing of the injections is determined by the disease stage.

Subgroup analyses showed trends or significant overall survival improvements for all subgroups measured, including by disease stage, ECOG score, age, and other factors.

Not exact matches

Solanezumab, a drug developed by Eli Lilly that also acts on the amyloid hypothesis, failed some key clinical trials, though the company is still testing it in the pre-clinical stages of the disease.

In a late - stage trial, Darzalex combined with Velcade and chemotherapy slashed patients» risk of worsening disease or death by a stunning 61 % compared with the results for Velcade and chemotherapy alone.

«The real opportunity for artificial intelligence,» he said, is detecting signs of disease sooner in the many people who «go from stage one to stage two to stage three cancer» before it's caught by a doctor.

Our goal is to complement the current strategic interest of Chiesi Farmaceutici in the space of rare diseases by investing in early stage opportunities and accelerate the expansion of the Chiesi network in the US among universities, venture capital investors, rare disease patient organizations and start - ups developing treatments for rare diseases.

Alnylam, which has been weighed down in the past by drug safety concerns, said it plans to initiate a program targeting cardiomyopathy - another symptom of the disease - alongside polyneuropathy in a late - stage study next year.

The Human Genome Project, not long ago completed at a cost of $ 3 billion, was often presented by its promoters as opening the way to discovering the ultimate genetic causes of all diseases, thus setting the stage for their cure.

The disease was deemed to be in its later stages by a Lyme disease specialist when it was diagnosed, who then recommended a treatment program of intensive antibiotic therapy for several months.

As defined by Custer in the early 1970s, the disease has three stages.

I worry that lost amidst the hoopla about the new CTE study is the fact that not every football player whose brain was donated to the CTE Center for pathological scrutiny was found to have the disease, and, that it was not detected in either the brains donated by the families of football players who died before they got to high school, and in only three of fourteen of high school players (and, in those, the disease had not progressed beyond the «mild» stage).

By the time Artvoice published last week the comments Paladino made in a year end survey — saying he wished death by mad cow disease upon President Barack Obama and wanted First Lady Michelle Obama to be «let loose in the outback of Zimbabwe where she lives comfortably in a cave with Maxie, the gorilla» — the developer was already on a national stage poised for scrutiny from some of the country's largest media outlets, including The New York Times, Washington Post and CNBy the time Artvoice published last week the comments Paladino made in a year end survey — saying he wished death by mad cow disease upon President Barack Obama and wanted First Lady Michelle Obama to be «let loose in the outback of Zimbabwe where she lives comfortably in a cave with Maxie, the gorilla» — the developer was already on a national stage poised for scrutiny from some of the country's largest media outlets, including The New York Times, Washington Post and CNby mad cow disease upon President Barack Obama and wanted First Lady Michelle Obama to be «let loose in the outback of Zimbabwe where she lives comfortably in a cave with Maxie, the gorilla» — the developer was already on a national stage poised for scrutiny from some of the country's largest media outlets, including The New York Times, Washington Post and CNN.

«But we have to be honest and say that, based on all the evidence, including data presented by the drug companies themselves, our experts have concluded that these drugs do not make enough of a difference for us to recommend their use for treating all stages of Alzheimer's disease.

[210] By then Wilson was the last surviving member of Attlee's cabinet, [211] and the unveiling of the statue would be one of the last public appearances by Wilson, who was by that point, in the early stages of Alzheimer's Disease and died at the age of 79 in May 199By then Wilson was the last surviving member of Attlee's cabinet, [211] and the unveiling of the statue would be one of the last public appearances by Wilson, who was by that point, in the early stages of Alzheimer's Disease and died at the age of 79 in May 199by Wilson, who was by that point, in the early stages of Alzheimer's Disease and died at the age of 79 in May 199by that point, in the early stages of Alzheimer's Disease and died at the age of 79 in May 1995.

By examining tissue from different disease stages within valve samples of the same patient, the researchers were able to avoid donor variation in their analysis.

24 Love and Other Drugs, a film by Edward Zwick, director of the 2006 film Blood Diamond, depicts an artist named Maggie (Anne Hathaway) in the early stages of Parkinson's disease.

The research, «Protein oxidation, nitration and glycation biomarkers for early - stage diagnosis of osteoarthritis of the knee and typing and progression of arthritic disease,» is published by Arthritis Research and Therapy.

Studies on the origins of BSE — a fatal disease marked in the early stages by loss of balance — gained urgency with the 1996 emergence in humans of the BSE - like new variant Creutzfeldt - Jakob disease (nvCJD).

In a groundbreaking study that provides scientists with a critical new understanding of stem cell development and its role in disease, UCLA researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research led by Dr. Kathrin Plath, professor of biological chemistry, have established a first - of - its - kind methodology that defines the unique stages by which specialized cells are reprogrammed into stem cells that resemble those found in the embryo.

The marker of antigens produced by pancreatic cancer has a low positive predictive value for identifying early stage disease.

As well as revealing step by step how disease and infection can aggravate and accelerate the early stages of Alzheimer's, Perry and his colleague Clive Holmes have begun a pioneering trial in 40 people to see if a drug that acts to dampen inflammation in the body can help delay the progress of the brain disease.

The Duke medical researchers and ecologists who have joined that project hope to identify which species flourish in early stages of the human microbiome, how they are influenced by the consumption of breast milk, and what role they play in critical diseases affecting infants as well as in chronic diseases that occur later in life.

By examining the quality of the tissue surrounding the cancerous glands, the researchers believe they can determine progression of the disease at the pre-surgical, or biopsy stage.

Those suffering from advanced stages of macular degeneration may by the end of this year be able to halt and even reverse vision loss caused by the age - related eye disease.

Alzheimer's is an agonizingly slow process, so by the time we get to study the disease itself during its late stages, all kinds of things have gone on that may be just consequences of disease rather than causal.

«In principle, one could save people suffering from cutaneous late - stage anthrax infections and maybe treat a variety of other similar diseases,» said Bier.

The technology can also easily be modified to detect multiple types of peptides released by different types or stages of disease.

«These drugs are highly effective and well - tolerated by patients at all stages of liver disease.»

By the time we get to look at the brain of a patient with Alzheimer's, it's really end - stage disease.

So now, with late - stage clinical failures piling up, the U.S. Food and Drug Administration (FDA) has set off down a path to adapt those standards as researchers are pushed inexorably into earlier and earlier forms of the disease, ahead of the brain damage inflicted by Alzheimer's.

Vtesse is currently running a late - stage clinical trial of the drug, a large sugar molecule known as a cyclodextrin, in which it is injected by lumbar puncture into the spinal fluid of children with the disease (see «Why are people fighting over a promising treatment for a fatal childhood disease»).

By identifying and profiling molecules that differ between different forms of dengue, the researchers lay the foundations for finding biomarkers present at early - stage dengue that are able to predict disease development.

At the clinic we're seeing significant pathology; people with complicated, end - stage, multisystem disease who have not been helped — or have even been hurt — by conventional medicine, and we're getting good outcomes.»

A drug used to treat men with late - stage prostate cancer proved effective in stemming progression of the disease in research participants who had not yet received chemotherapy and extended their survival, according to results from a multi-national Phase III clinical trial led by the Knight Cancer Institute at Oregon Health & Science University (OHSU).

First, after a person is bitten by a parasite - carrying mosquito there is an initial infection in the liver, followed by the long - lasting red blood cell stage where the clinical symptoms of the malaria disease occur, and finally the mosquito stage, which is required to transmit the parasites to other people.

By comparison, another 96 Alzheimer's patients who were at a similar age and stage of the disease rose by up to six pointBy comparison, another 96 Alzheimer's patients who were at a similar age and stage of the disease rose by up to six pointby up to six points.

The entorhinal region is one of the first parts of the brain affected by Alzheimer's disease, so the findings may also help to explain why people start to get lost in the early stages of the disease.

Estimates show that a five - year delay in the terrible and expensive dementia stage of the disease would reduce Medicare dementia costs by nearly 50 percent.

Participants enrolled in the Study in Parkinson Disease of Exercise (SPARX) were at an early stage of the disease and not taking Parkinson's medication, ensuring the results of the study were related to the exercise and not affected by mediDisease of Exercise (SPARX) were at an early stage of the disease and not taking Parkinson's medication, ensuring the results of the study were related to the exercise and not affected by medidisease and not taking Parkinson's medication, ensuring the results of the study were related to the exercise and not affected by medication.

High - intensity exercise three times a week is safe for individuals with early - stage Parkinson's disease and decreases worsening of motor symptoms, according to a new phase 2, multi-site trial led by Northwestern Medicine and University of Denver scientists.

A study published March 7th by Cell Press in the journal Cell reveals that a compound derived from fats found in fish oils prevents death in influenza - virus - infected mice, even at advanced stages of disease.

For this study, the researchers used data from a population of patients with both diabetes and chronic kidney disease (stage 3 and 4) enrolled in follow up studies conducted by Dr. Krolewski and his team at the Joslin Diabetes Center and followed for four to 15 years.

She has found that those who have a sub-group not dominated by tremors often fall at an early stage of the disease.

Understanding which cytokines are best for monitoring inflammation and immunosuppression, and knowing which are secreted by different immune cell types at each stage of maturation and activation, will provide essential insights into disease treatment options.

By receiving transplants of bone marrow cells along with the new kidney, four of five transplant patients with end - stage renal disease were able to stop taking immunosuppressive drugs within about one year after surgery.

A study done by researchers at Fox Chase Cancer Center shows that many relatives of patients who undergo testing for a gene linked to breast and ovarian cancers misinterpret the results, and less than half of those who could benefit from genetic testing say they plan to get tested themselves — despite the fact that knowing your genetic status may help catch the disease in its earliest stages.

You might expect that the next advances in cancer prevention will mean better and more frequent tests that will pick up tumors at the earliest possible stage, followed by a blitzkrieg treatment that will completely wipe out the disease.

Patients affected by Parkinson's disease often show marked changes in body weight: they may gain or lose a lot of weight depending on the stage of the disease, or they may put on up to ten kilos after deep brain stimulation (a treatment to alleviate the symptoms).

A team of researchers led by UNSW Australia scientists has discovered how connections between brain cells are destroyed in the early stages of Alzheimer's disease — work that opens up a new avenue for research on possible treatments for the degenerative brain condition.

Using scNMT - seq to spot changes could also be critical to detecting the very early stages of genetic diseases, long before they can be found by conventional medicine.