Sentences with phrase «by dysregulation»

We postulate that the kidney phenotype in BicC1 mutant mice is caused by dysregulation of a microRNA - based translational control mechanism.

Not exact matches

Millendo develops novel, disease - modifying treatments for specialty and orphan endocrine diseases caused by hormone dysregulation.

Depressed mothers are often overwhelmed in the parenting role, have difficulty reading infant cues, struggle to meet the social and emotional needs of their children, and are less tolerant of child misbehaviour.7 Offspring of depressed mothers, particularly if they are exposed to depression in the first year of life, are more likely to be poorly attached to their caregivers, experience emotional and behavioural dysregulation, have difficulty with attention and memory, and are at greater risk for psychiatric disorders throughout childhood.8 Home visiting focuses on fostering healthy child development by improving parenting and maternal functioning.

«We are excited by the work of Dr. Pourdehnad and colleagues and believe these results are an important advance in understanding the role of myc pathway dysregulation in multiple myeloma, and ultimately allow for the development of therapeutic strategies to address it,» said Jeffrey Wolf, MD, a UCSF blood disorder specialist and director of the Stephen and Nancy Grand Multiple Myeloma Translational Initiative at UCSF, a sponsor of the research.

You can test this idea by looking at the earliest stages of dysregulation.

ADHD, one of the most common neurobehavioral disorders worldwide, is characterized by inattention, hyperactivity, increased impulsivity, and motivational and emotional dysregulation.

«And early developmental brain enlargement can be explained by underlying molecular and cellular pathway dysregulation, leading to altered neuronal cortical networks.»

In Nrk mutant mice, therefore, mammary tumorigenesis was proposed to be triggered by a combination of dysregulation of proliferation in mammary epithelial cells and excessive blood estrogen.

The disease is characterized by profound fatigue and disability lasting for at least 6 mo, episodes of cognitive dysfunction, sleep disturbance, autonomic abnormalities, chronic or intermittent pain syndromes, microbiome abnormalities (1), cerebral cytokine dysregulation (2), natural killer cell dysfunction (3), and other symptoms that are made worse by exertion of any kind (4).

The «hotspots» of these trans associations, when grouped by pathway, highlight known targets of dysregulation in breast cancer such as ERBB2 and MYC.

Behind our diverse and growing pipeline is a mission to bring forth a new generation of highly efficacious drugs, driven by an unparalleled understanding of immune dysregulation.

HTLV - 2 Tax immortalizes human CD4 + memory T lymphocytes by oncogenic activation and dysregulation of autophagy.

HTLV - 2 Tax immortalizes human CD4 + memory T lymphocytes by oncogenic activation and dysregulation of autophagy % U http://www.jbc.org/content/early/2012/08/13/jbc.M112.377143.short.

N - glycosylation is important for efficient trafficking of GLUT4 to its proper compartments in adipocytes (51), suggesting one mechanism by which dysregulation of these genes could contribute to T2D.

IL - 17 is produced mainly by pathogenic ILC3s associated with chronic inflammation and cytokine dysregulation [11] and we did not readily detect IL - 17 in our studies.

We also propose that the dysregulation of the balance between sphingolipids and glycerophospholipids results in a lipotoxic insult relevant in the pathophysiology of common metabolic diseases, typically characterised by their increased ceramide / sphingosine pools.

By developing a simple chemically defined culture system permitting efficient differentiation of numerous human iPS cell lines toward cells of a mature hepatic state, we now demonstrate the possibility of modeling groups of diseases of non-neuronal origin whose phenotypes are a consequence of complex protein dysregulation within adult cells.

Cytokines treat infections by turning on various white blood cells, but also cause pain, achiness, fatigue, hormonal dysregulation, and poor sleep.

While most of her hormone production plummets, her DHEA - S production (the top - of - the - food - chain hormone produced by the adrenal gland) skyrockets in response to HPA axis dysregulation.

The hormonal dysregulation is part of the body's method for coping with a pathology, and by altering hormone levels you may disrupt the body's response to the disease, allowing it to do more harm.

This dysbiosis may be exacerbated by mercury's dysregulation of the immune system as well as its promotion of metabolic acidosis.

By addressing physical, chemical and mental stress, athletes can significantly improve their overall health and fitness, with the result of better performances and lower risks of water and sodium dysregulation.

Exacerbating the mineral dysregulation associated with these many conditions are the neurotransmitter imbalances provoked by mercury.

What I call «unfair weight gain» occurs in women with PCOS because of the hormonal dysregulation and chronic low grade inflammation caused by this disorder.

They also may inhibit leptin, a hormone made by adipose cells which inhibits hunger and this dysregulation may be one of the ways that feeding infant formula encourages obesity and weight gain in infants and later in life.59 • Protease inhibitors are substances that inactivate some key digestive enzymes like trypsin and chymotrypsin and are associated with pancreatitis and pancreatic enlargement.

Adrenal fatigue is caused by any or all types of stress on the body (including emotional, mental or physical stress) which lead to the dysregulation of cortisol — our body's main anti-stress hormone.

And, we'll tie together the previous levels by connecting how inflammation related to the previous system discussions - poor digestion, immune dysfunction, hormonal dysregulation, genetic snps, and environmental toxin exposures (including emotional toxins)- contribute to an increased risk of chronic rehab challenges, including chronic joint pain, poor surgical or injury recovery, obesity, memory loss or dementia, diabetes, or even poor sports performance.

«Inactivity, sleep disturbance, psychiatric comorbidity, medication, and ongoing stress experienced by people with CFS will affect HPA axis function, and the findings that HPA axis dysregulation is more prominent in patients with a longer duration of illness suggest that the endocrine changes may be secondary.»

The best method of diagnosing insulin dysregulation is by giving the horse a dose of corn syrup and checking an insulin level 60 and 90 minutes later.

Linear regression by stepwise shows that both extraversion and agreeableness explain 66.5 % of the variance of the emotion regulation score; and extraversion, agreeableness and emotional stability explain 68.3 % of the variance of the emotion dysregulation score.

Overwhelmed by such feelings as chronic stress, anxiety, anger, isolation, disillusionment, low self - esteem, and depression, we become stuck in a state of emotional dysregulation that literally changes our ability to intuitively find our balance.

Children who do not complete high school, for example, are more likely to become teenage parents, to be unemployed, and to be incarcerated, all of which exact heavy social and economic costs.5 A growing body of research shows that child poverty is associated with neuroendocrine dysregulation that may alter brain function and may contribute to the development of chronic cardiovascular, immune, and psychiatric disorders.6 The economic cost of child poverty to society can be estimated by anticipating future lost productivity and increased social expenditure.

I love the fact that these authors were able to reflect real - life psychotherapy by taking an eclectic approach to the treatment of emotion dysregulation.»

Food may be used in excess as a tool for consoling or pacifying emotional needs of the child by the parent31 or to self - soothe by the child.32, 33 Alternatively, family violence is distressing and may cause affective dysregulation, leading to decreased impulse control and excessive caloric intake.34 More direct biological mechanisms are also plausible.

Other studies (e.g., Anderson et al., 2008) have shown that high levels of stress (such as that induced by exposure to ACEs) lead to dysregulation of the limbic system, resulting in a rewiring of the brain which causes children to be more anxious and hyper - responsive to negative social cues, such as angry facial expressions from others.

The present study was driven by recent findings about the relationship between beliefs about emotions, behaviours associated with emotion dysregulation, and specific ER processes (Tamir et al., 2007; Manser et al., 2012; De Castella et al., 2013).

Extreme affective lability, which is experienced by patients with bipolar disorder, may have contributed to the significant HRV dysregulation in these patients.

Generally, the current study represents a wider framework toward understanding the important role beliefs about emotions play in the understanding of emotion dysregulation, as delineated by several theories, researches and clinical observations (Gross & Thompson, 2007; Werner & Gross, 2010).

Moreover, DSM - 5 trait dimensions also add features such as eccentricity, perceptual dysregulation (dissociation), unusual beliefs and experiences, deceitfulness, and manipulativeness to individualized case - formulations, which are not covered by schema therapy constructs.

Because the capacity to tolerate our emotions without becoming overwhelmed or shutting down depends upon secure attachment, the therapeutic work is often challenged by the client's vulnerability to affect dysregulation.

The DSM IV, which is a manual used by psychiatrists to diagnose all mental disorders, describes BPD as an AXIS 11 disorder of impulsivity and emotional dysregulation including at least five of the following (See Gray Box Below):

We also discuss the recent controversy about BD in children and adolescents that has led to the introduction of the diagnosis of disruptive mood dysregulation disorder (DMDD) by the Diagnostic and Statistical Manual for Mental Disorders (DSM)-5.

The prenatal phase of the program reduced fetal exposure to tobacco, improved the qualities of women's prenatal diets, reduced rates of pyelonephritis, improved levels of informal social support, and reduced intellectual impairment and irritable behavioral styles associated with fetal exposure to tobacco.6, 10,11,22 Prenatal exposure to tobacco is a risk factor for early behavioral dysregulation, problems with attention, and later crime and delinquency.22 Moreover, the combination of birth complications (and, by implication, neurological impairment) and rejecting parenting substantially increases the likelihood of violent offenses by the time children are 18 years old.5

DBT teaches the person skills to cope with their emotional dysregulations, to focus on the moment by being mindful, distress tolerance skills and interpersonal effectiveness skills.

McEwen has characterized these accumulated risks as «allostatic load:» As physiological systems fluctuate to meet the demands posed by a stressful environment, physiological costs of chronic exposure to recurring or heightened neural or neuroendocrine responses to repeated or chronic stress accumulate, resulting in interacting dysregulations in multiple physiological systems (10).

Following Allan Schore's very successful books on affect regulation and dysregulation, also published by Norton, this is the third volume of the trilogy.

Complex Trauma, Attachment and Dissociative Symptoms: Treating Children with Pervasive Emotion Dysregulation Using EMDR Therapy and Adjunctive Approaches by Ana Gomez, MC, LPC

It is the beginning formation of narcissistic entitlement and borderline emotional dysregulation in the child as a product of distorted parenting practices by a narcissistic / (borderline) personality, who holds the distorted beliefs that the child is acquiring.

The index represents the sum of physiological dysregulations in the body of an individual in response to chronic stressful situation prior to onset of medical illnesses, and is measured by a combination of biomarkers of health such as adiposity, blood pressure and plasma glucose level.

An acute fear response is often accompanied by emotional and behavioral dysregulation.