Sentences with phrase «by early onset»

[68] Taking into account the injuries caused by the negligence of the Defendants, the duration of the pain and suffering produced by the negligence, the likely future pain and suffering caused by the Fall, and by the early onset of arthritic problems caused by the Fall, I set the non-pecuniary damages available to Mr. Witt at $ 100,000.00.

The disease is characterized by early onset muscular problems such as awkward gait, fatigue, and difficulty eating.

Juvenile amaurotic idiocy: a syndrome characterized by early onset blindness and low mental capacity.

The study, led by Dr Yalda Jamshidi from St George's, University of London and Dr Chiara Manzini from George Washington University, examined the DNA of five individuals who were affected by early onset of a group of conditions including muscle weakness and an inability to stand or walk.

Two pregnancies were complicated by early onset pre-eclampsia, abnormal antepartum testing and extreme prematurity, with one subsequent neonatal death.

Not exact matches

«It is our hope that by targeting people earlier, we will have a better chance of delaying or preventing the onset of the disease,» said BAI director Dr. Pierre N. Tariot in a statement.

Most women don't understand that the incidence of endocrine disruptive disorders such as endometriosis, fibroids, polycystic ovarian syndrome, infertility, early onset puberty, early onset menopause, heavy, painful and prolonged periods and breast cancer are mainly caused by the endocrine disruptive chemicals found in skin, hair, beauty and personal products.

After the game, Krzyzewski called passing Summit «an honor,» but also noted that «Pat would have won a lot more» had her coaching career not been cut short by an early - onset Alzheimer's diagnosis in 2012.

I think Tottenham Hotspur will bid their time in this game and not play an open attacking game at the onset of the match, but play with caution defending against the early assaults by the Gunners» attacking machines.

Wenger who had been a God, morphed, under the temptation of huge salary assurances and supreme power gifted to him by an owner and a board without honour and crucially, any understanding of modern football, into a tinpot dictator, ageing and descending into early onset dementia, rather like Robert Mugabe.

Attorneys representing all current and former NCAA student - athletes announced date changes made by the court, affecting the concussions settlement that will provide a 50 - year medical - monitoring program for student - athletes to screen for post-concussion syndrome and early - onset neurodegenerative disease that may have resulted from concussions or the accumulation of subconcussive hits while playing NCAA sports.

From the last study «The incidence of invasive early - onset GBS disease decreased by more than 80 % from 1.8 cases / 1000 live births in the early 1990s to 0.26 cases / 1000 live births in 2010; from 1994 to 2010 we estimate that over 70,000 cases of EOGBS invasive disease were prevented in the United States.»

It was suggested as early as the 1950s that breast - fed infants have a later onset of celiac disease (27), and this view was later shared by others (28,29).

They also believe that by measuring a patient's dark adaptation response time they have developed a tool that can help track the onset or progression of the disease as well as measure the effectiveness of drugs that are in development to treat the disease early on.

From 1975 to 2016, the spring snowmelt has arrived nearly three days earlier every decade, and from 1979 - 2016, snow onset has arrived later, by about 4.5 days every decade.

BD is commonly preceded by early depression or other symptoms of mental illness, sometimes years before BD develops, as indicated by onset of mania or hypomania.

Not long after the HD gene was isolated, studies led by MacDonald, also a co-author of the current investigation, found that a variation in the number of CAG trinucleotide repeats within the HD gene, which codes for a protein called huntingtin, is the primary determinant of the age at which HD symptoms appear, with a greater number of CAG repeats associated with an earlier symptom onset.

The billion - year time lag between the earliest, «proto - subduction» and the full onset of plate tectonics can be explained by the slow, painstaking development of weak zones within the plates, he proposes.

In 2006, the team led by Christine Petit in the Institut Pasteur's Genetics & Physiology of Hearing Unit, especially Sedigheh Delmaghani, working in cooperation with Paul Avan's team at the University of Auvergne's Laboratory of Sensory Biophysics, identified a new gene that was responsible for early - onset sensorineural hearing loss.

Led by Brenda Penninx, PhD, of the VU University Medical Center in Amsterdam, the Netherlands, the study found that patients with an early age at onset and higher symptom severity have an increased genetic risk for MDD, bipolar disorder and schizophrenia.

Jonscher believes the antioxidant may work by impacting pathways critical to the early onset of diseases associated with maternal obesity, high fat diets and inflammation.

The team argues that when the quality and accuracy of the dating — which was based on radiocarbon and other techniques — is examined closely, only three of the 29 sites actually fall within the time frame of the Younger Dryas onset, about 12,800 years ago; the rest were probably either earlier or later by hundreds (and in one case, thousands) of years.

A study published in the July 16 issue of The Journal of the American Medical Association suggests that doctors may be able to anticipate the onset of autism much earlier by using a simple tool: a tape measure.

The researchers were limited by the scans available, so they were unable to test whether the algorithm could predict the onset of disease even earlier.

Age of onset varies considerably, but learning delays and clumsiness may emerge in early childhood, followed by progressive loss of brain function, including loss of motor control, hearing, speech and cognition.

A team of researchers led by Patrik Verstreken (VIB - KU Leuven) have identified an underlying mechanism in early onset Parkinson's.

Genetic factors are clearly indicated as evidenced by dominant mutations in three different genes have been identified that account for the small number of cases of familial, early - onset AD.

In Yarumal and the surrounding state of Antioquia, 5000 people carry a gene mutation which causes early - onset Alzheimer's — half of them will be diagnosed by the age of 45, and the other half will succumb by the time they are 65.

So the team tested 116 people with early - onset testicular cancer, breast cancers not explained by known mutations, or early - onset colorectal cancer.

Clinical trials scheduled to begin later this year will test this idea by giving anti-amyloid drugs to people genetically predisposed to early - onset Alzheimer's disease before they develop symptoms.

It is now known to be a form of early onset Alzheimer's, caused by a mutation in a gene called PSEN1.

Dr. Romero emphasized that the cost of preeclampsia goes beyond the short - term health care expenditures as women affected by this disorder are at an increased risk for early onset cardiovascular diseases, such as heart attacks and hypertension, years and decades after delivery.

The potential for early diagnosis and delaying the onset of motor or cognitive decline by perhaps ten years is of potentially profound importance in an aging society.»

By identifying body changes at the cellular level, PET may detect the early onset of disease before it is evident on other imaging tests.

Our approach differs from that adopted by Charlesworth [61], [62], who developed mathematical models to formalize the mutation accumulation hypothesis [63] that, together with the antagonistic pleiotropy hypothesis [3], [64], may be used to show how senescence can evolve by the accumulation of deleterious alleles through mutation - selection balance at frequencies that increase with their age of onset; such mutations enhance reproductive performance early in life but diminish survival late in life through physiological trade - offs.

The team examined three forms of retinal degenerative diseases, rod cone dysplasia 1 being the most severe, or earliest onset, followed by X-linked progressive retinal atrophy 2 and then early retinal degeneration.

Although many people think of Alzheimer's disease as something that only affects older adults, there are actually two types of Alzheimer's disease: late onset (also called typical) Alzheimer's which affects people over the age of 60 and early onset Alzheimer's, which is defined by symptoms that begin before age 60.

In Glenner's scenario, amyloid - beta is the primary culprit, and that notion has been strengthened by studies of early - onset Alzheimer's, which accounts for about 5 % of Alzheimer's cases.

This can be caused by a number of spinal deformities such as congenital scoliosis, missing ribs, fused ribs, deformed vertebrae, or other types of severe early onset scoliosis.

Following a period of intensive meditation, genes involved with the infectious cycle may get downregulated along with related host genes regulating protein synthesis, an explanation that is supported by other stress reduction interventions that have shown increased innate antiviral activity, such as upregulated Type 1 interferon activity.40 Shorter telomeres in population - based studies have been predictive of earlier onset of chronic diseases of aging, including diabetes, 41 cardiovascular disease9 and certain cancers.42

If it does, then you might use the approach of making more beta cells right at early onset of the type 1 disease to try and stop or reverse the immune attack, making the immune system think its made a mistake, inducing something called anergy by making more beta cells.

To test whether clinicoanatomic heterogeneity in AD is driven by the involvement of specific networks, network connectivity was assessed in healthy subjects by seeding regions commonly and specifically atrophied in three clinical AD variants: early - onset AD (age at onset, < 65 y; memory and executive deficits), logopenic variant primary progressive aphasia (language deficits), and posterior cortical atrophy (visuospatial deficits).

Early onset autosomal recessive parkinsonism is caused by mutations in the parkin, PINK1, and DJ - 1 genes (Kitada et al., 1998; Bonifati et al., 2003; Valente et al., 2004).

The strongest link between having a mutation in this particular gene in the family and having multiple family members with melanoma, early onset, and so forth, was in Europe followed by North America and then Australia.

They also believe that by measuring a patient's dark adaptation response time they have developed a tool that can help track the onset or progression of the disease as well as measure the effectiveness of drugs that are in develpoment to treat the disease early on.

Scientific research provides abundant evidence that a poor prenatal diet, followed by a steady childhood diet of low - nutrient food spawns a whole host of physical defects and diseases, including early - onset osteoporosis, diabetes, coronary occlusion, obesity, acne, dental irregularities and, most important, acute distortions in brain chemistry — bizarre distortions with macabre perceptions that could easily trigger the tragic shootings on our school campuses.

The peripheral sink Aβ hypothesis indicates that the peripheral clearance of Aβ and its regulation by dietary phytosterols is of substantial interest since it may delay hypercholesterolemia and the early onset of amyloid plaque development.

by dietary phytosterols is of substantial interest since it may delay hypercholesterolemia and the early onset of amyloid plaque development.

Since cortisol abnormalities are not typically present at the onset or early stages of chronic fatigue, and since cortisol abnormalities are not present at all in the vast majority of people with chronic fatigue, a reversed direction of causation — where cortisol abnormalities are caused by other factors, inactivity, medication use, poor sleep, etc. — is the most compelling explanation for cortisol abnormalities, in the minority of people with chronic fatigue who do have them.

Anabolic steroids cause muscle hypertrophy of both types (I and II) of muscle fibers caused likely by an increased synthesis of muscle proteins and are accompanied with undesired side effects including hepatotoxicity, gynecomastia, acne, the early onset of male pattern baldness and a decline in the body's own testosterone production, which can cause testicular atrophy.