Sentences with phrase «by endocannabinoid»

The exact role played by these endocannabinoids in reproduction is unclear, but high levels are associated with miscarriage in women.

CB1 is activated by endocannabinoids and is a promising therapeutic target for pain management, inflammation, obesity, and substance abuse disorders.

YanGang Sun, Chia - Shan Wu, Hui - Chen Lu, Michael Beierlein «Target - dependent control of synaptic inhibition by endocannabinoids in the thalamus» (2011), Journal of Neuroscience, 31:9222 - 30.

Not exact matches

The PAM used in the IU - led study worked by amplifying two brain compounds — anandamide and 2 - arachidonoylglycerol — commonly called «endocannabinoids» because they act upon the CB1 receptor in the brain that responds to THC, the major psychoactive ingredient in cannabis.

But they were in the dark about the role of endocannabinoids — the kind made by the brain — during fetal development.

The work describes for the first time that overeating associated with chronic consumption of a western diet is driven by an enhancement in endocannabinoid signals generated in peripheral organs.

That boosts pain relief in a targeted way — when endocannabinoids are already being released by the body, such as after injury or stress.

The natural endocannabinoid system regulates anxiety and the response to stress by dampening excitatory signals that involve the neurotransmitter glutamate.

Led by first author Teniel Ramikie, a graduate student in Patel's lab, the researchers also showed for the first time how nerve cells in this part of the brain make and release their own natural «endocannabinoids.»

Chemically modified inhibitors of the COX - 2 enzyme relieve anxiety behaviors in mice by activating natural «endocannabinoids» without gastrointestinal side effects, Vanderbilt University scientists will report next week.

They also have found that chemically modified inhibitors of the COX - 2 enzyme they developed relieve anxiety behaviors in mice by activating natural «endocannabinoids» without gastrointestinal side effects.

The Vanderbilt scientists are pursuing other potential applications of activating endocannabinoids by substrate - selective COX - 2 inhibition, including relieving pain, treating movement disorders, and possibly preventing colon cancer.

Current studies in the Parsons laboratory are investigating whether binge patterns of drug consumption evoke similar endocannabinoid disruptions, and they are probing the influence of impaired endocannabinoid signaling in the excessive motivational effects produced by drug - associated conditioned cues.

Endocannabinoid 2 - arachidonoylglycerol protects neurons by limiting COX - 2 elevation.

It would also implicate the endocannabinoid system as a potential therapeutic target to facilitate regeneration of neural connections destroyed by glaucoma.

Stephen Alexander, UK - Cannabinoid receptors, transporters, endocannabinoid turnover, hydrogen sulphide turnover Arthur Christopoulos, Australia (GPCRs Liaison)- G protein - coupled receptors; analytical pharmacology; allosteric modulation; biased agonism; drug discovery; neuropharmacology John Cidlowski, USA (NHRs Liaison)- Glucocorticoid receptor signaling; apoptosis and the immune system Anthony P. Davenport, UK (Chair Evolving Pharmacology, GPCRs Liaison) Doriano Fabbro, Switzerland - Kinases and their biology, kinase inhibitors, drug discovery, pharmacology of drugs (kinase inhibitors) in the indication oncology, biology of oncology Kozo Kaibuchi, Japan Yoshikatsu Kanai, Japan - Transporters, amino acid signals, epithelial function, cancer biology Francesca Levi - Schaffer, Israel - eosinophils and mast cells as effector cells in allergic inflammation: characterization of new receptors / ligands, hypoxia / angiogenesis and eosinophils, asthma, atopic dermatitis, allergic rhinitis, immunopharmacological modulation of allergic diseases by bispecific recombinant antibodies, bacteria interactions with eosinophils and mast cells, the allergic effector unit, mast cell derived tumors: new antibody based treatment, the allergic inflammation and the resolvome, non IgE - mediated mast cell activation in diseases Eliot H. Ohlstein, USA (Editor)- Drug discovery and development, urogenital biology, cardiovascular / metabolic medicine John A. Peters, UK (LGICs Liaison) Alex Phipps, UK - Oncology, Clinical Pharmacology, Biologics and Immunotherapy Joerg Striessnig, Austria (VGICs Liaison)- Physiology, pharmacology and pathophysiological role of voltage-gated calcium channels

Aug. 5, 2013 — Chemically modified inhibitors of the COX - 2 enzyme relieve anxiety behaviors in mice by activating natural «endocannabinoids» without gastrointestinal side effects, Vanderbilt University scientists will report next week.

In essence, it is proposed that the endocannabinoid system, selected by 600 million years of evolution, is a central mediator of biological harm reduction through its homeostatic activities.

On the other hand, when they intentionally blocked their endocannabinoid system, the exercise wasn't followed by the same beneficial effects.

Research shows cannabinoids can stop inflammation by activating CB2 receptors found in the human endocannabinoid system.

A hemp revival fueled by unified groups of farmers, doctors, nutritionists, environmentalists, and businesses gained even more momentum with the exciting discovery of the endocannabinoid system in the 1990s.

As research into medical cannabis continues to capture the attention of many in the scientific and medical communities (as well as many in the general public), we are also learning more about the health benefits brought on by the best combination of non-cannabis botanical compounds, foods, and lifestyle activities (e.g., acupuncture, exercise, and aromatherapy) that interact with the endocannabinoid system (ECS).

on neurons and peripheral cells, receptors which are normally engaged by natural endogenous substances (called endocannabinoids) that your body already makes, but that also can be bound by substances from exogenous (outside) sources.

The revolutionary insight that humans have an endocannabinoid system, which controls executive function, mood, social behavior, and pain, is conserved from invertebrates to high mammals, and can be activated by cannabinoids in marijuana, renewed interest in its medicinal applications (5, 52).

The lower Body Mass Index (BMI) of pot - smokers may be explained by an adaptive down - regulation of brain endocannabinoid signaling.

The phytocannabinoids produced by cannabis are not the same thing as the endocannabinoids, but the similarities are what make it so vitally important as a medicine.

It is able to limit inflammation within the body by interacting with the endocannabinoid system and thus the immune system.

By encouraging the efforts of your pet's endocannabinoid system, CBD promotes cardiovascular function, supports healthy joints, and promotes neurological health and emotional behavior.

CBD supports the endocannabinoid system and encourages its efforts to keep your pet's functions in balance by interacting with cannabinoid receptors found in the brain and central nervous system.

A well - operating endocannabinoid system is essential to your for maintaining health and wellness, and CBD is able to stimulate the endocannabinoid system by interacting with its cannabinoid receptors.

According to an article by Dr Karen Becker, dogs also get that «runner's high» known in humans, from the release of endocannabinoids from running — making walk time, or «run time,» a good time to boost those «happy hormones» for you and your dog.