Sentences with phrase «by epigenetic markers»
Determining how ES cell genes are modified by these epigenetic markers may explain these cells» unique characteristics, said the scientists, who are based at the Genome Institute of Singapore (GIS) and the Bioprocessing Technology Institute (BTI), both under the Agency for Science, Technology and Research (A * STAR), as well as at the National University of Singapore (NUS).
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The scientists also discovered that genes modified only by one of the epigenetic markers, H3K4me3, contain the DNA recipes for proteins that enable an ES cell to proliferate, or duplicate itself.
With the sequence data in hand, the scientists were able to categorize the genes into three groups, each modified by different combinations of the two epigenetic markers.
Therefore, histone marks represent an epigenetic marker or code that can be used by the cells to expand their plasticity and complexity.
It's the first time that scientists have shown they can get stem cells to revert to their original state by erasing specific labels called epigenetic markers.