Sentences with phrase «by epigenetic regulation»
Instead, viruses mute the immune system by epigenetic regulation — instead of changing the actual code of genes, viruses change the degree to which genes are expressed.
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«Our study connects the dots between Werner syndrome and heterochromatin disorganization, outlining a molecular mechanism by which a genetic mutation leads to a general disruption of cellular processes by disrupting epigenetic regulation,» says Izpisua Belmonte.
We aim at understanding (1) the regulatory properties emerging from and the constrains imposed by the modular and dynamic organisation of the network; (2) the epigenetic mechanisms ensuring the rapid reestablishment of the network after each cell division and, conversely, those promoting its dismantling upon differentiation; (3) the contribution of non-coding RNAs to the regulation of the network's activity.
And we think that the regulation of those cells that results in behaving as if we are in a chronic stress kind of environment is explained by this field that's burgeoning right now that's referred to as epigenetics that talks about the programming of our cells.
Regulation of the epigenetic landscape by the formation and resolution of RNA - containing chromatin structures
Through this packaging mechanism, researchers think that histone proteins are the key to regulating access to the genetic information by making different parts of the DNA accessible to factors that express the gene, so - called epigenetic regulation.
We also have research interests in cellular regulation by ADP - ribosylation, which links epigenetics to metabolism; lipid kinases; and sphingolipid biosynthesis, which has strong links to both inflammation and cancer, and where mutations in the various proteins involved are associated with a variety of rare diseases.
We have found that blastocysts produced by suboptimal IVC exhibit transcriptional repression of some genes (Sox2, Hdac1, Kap1, Dnmt1, and Dnmt3a) that are modifiers of epigenetic gene silencing through the regulation of the transcription of specific genes, which involves changes in the chromatin state.