Sentences with phrase «by factor exposures»

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

The ideal portfolio optimization algorithm perfectly balances trading costs, instruments, asset classes, factor exposure (but only when needed), strategies, and does it all under constraints imposed by risk management.

The consumer ratings agency compared the cost of a Tesla solar roof in New York, Texas and California and deemed that — depending on factors such as electricity cost and sun exposure — the numbers generated by Tesla's Solar Roof calculator check out.

Specifically, they construct portfolios that scale exposure to a stock factor portfolio or a currency carry trade by the inverse of expected variance.

The product is derived from Morningstar's Global Risk Model, released in 2016, which tracks portfolio risk by monitoring each stock's underlying economic exposure to 36 factors.

Rather than relying solely on market exposure to determine a stock's performance relative to its index, smart beta strategies allocate and rebalance portfolio holdings by relying on one or more «factors.»

Specifically, a recent analysis by Graham Secker, MS & Co.'s European equity strategist, found that recent disappointments in European corporate profits are a function of at least three important factors that may be reversing: idiosyncratic issues related to heavily skewed index exposure to financials and commodity - linked industries; weak operating profit leverage linked to declining emerging market sales; and less aggressive use of buybacks, tax optimization and non-operating cost reductions versus U.S. peers.

By systematically and deliberately setting exposure factors such as momentum, quality, or value, managers can utilize smart beta strategies to improve returns, reduce risk or enhance diversification.

By adding alternative asset classes, we can enhance diversification by selecting exposure to factors that don't typically come from a traditional balanced portfolio of stocks and bondBy adding alternative asset classes, we can enhance diversification by selecting exposure to factors that don't typically come from a traditional balanced portfolio of stocks and bondby selecting exposure to factors that don't typically come from a traditional balanced portfolio of stocks and bonds.

VIDI allocates to countries based on their perceived ability to withstand economic shocks as determined by multiple factors, an approach that can produce significant and unusual differences from market - weighted country exposure, including a bias to emerging countries.

If anything, the first few weeks of the year have served as a valuable reminder that investing in public markets is inherently volatile and that our main defense against that volatility is to diversify our risk exposures by owning a variety of asset classes and risk factors.

Over production of androgen / testosterone can be caused by a number of factors, both environmental (such as exposure to a man who uses testosterone gel) or biological factors such as a thyroid or pituitary problem.

Involvement in the multitudinous problems of a rapidly expanding urban area or exposure to the increasingly bitter struggle between labor and management or entanglement in the luxuriant and rank growth so abundantly fostered by the new wealth of the «gilded age»: these and other factors caused many men to re-examine their roles as ministers and to seek more effective ways of ministering to the needs of their time.11 Perhaps the most important thing that happened to such men was that they became aware of the many factors bearing on human welfare and thus of importance to the Christian gospel.

In 2008, the Journal of Sports Economics published a study that suggested a recruit's decision on where to attend college is «governed by a handful of primary factors» including «the opportunity for individual success and exposure, a team's recent on - field success and the distance to the school from his hometown.»

It's also probably true that the increased incidence of all of these problems is a result of decreased exposure to nursing which is influenced by societal perceptions of nursing (and older maternal age can be a factor in milk production).

He described the goal of reducing the overall number of head impacts that high school football players sustain in a season as «logical» and «appealing,» but noted that, «until the risk factors for chronic traumatic encephalopathy [25](CTE) are better defined by carefully designed and controlled research,» and research determines «what the advisable limit to head impact exposure should be,» employing contact limits or establishing «hit counts [4]» will remain «educated guesses, at best.»

These symptoms usually are triggered by an exposure to an allergen, virus or other factor such as pollution or cold air.

It is also influenced by some as yet unknown environmental factors (some speculate a susceptibility to certain viruses such as coxsackie, others implicate exposure to certain very specific chemicals, most certainly not included in baby formula).

The most recent study report described in these same regions decreased tissue levels of 5 - HT and tryptophan hydroxylase, the synthesizing enzyme for serotonin, and no evidence of excessive serotonin degradation as assessed by levels of 5 - hydroxyindoleacetic acid (the main metabolite of serotonin) or ratios of 5 - hydroxyindoleacetic acid to serotonin.30 A recent article described a significant association between a decrease in medullary 5 - HT1A receptor immunoreactivity and specific SIDS risk factors, including tobacco smoking.40 These data confirm results from earlier studies in humans39, 41 and are also consistent with studies in piglets that revealed that postnatal exposure to nicotine decreases medullary 5 - HT1A receptor immunoreactivity.42 Animal studies have revealed that serotonergic neurons located in the medullary raphe and adjacent paragigantocellularis lateralis play important roles in many autonomic functions including the control of respiration, blood pressure, heart rate, thermoregulation, sleep and arousal, and upper airway patency.

Breastfeeding helps protect against these and other infections by providing antibodies and other protective factors, minimizing exposure to pathogens, and ensuring optimum nutrition.

Researchers determined the extent of relative climate sensitivity in the reserves by looking at five factors: social, biophysical, and ecological sensitivity, and exposure to temperature change and sea level rise.

Environmental risk factors and exposures can also contribute to BD risk, according to the analysis by Ciro Marangoni, MD, at the Department of Mental Health, Mater Salutis Hospital, Legnato, Italy; Gianni L. Faedda, MD, Director of the Mood Disorder Center of New York, NY, and Co-Chairman of a Task Force of the International Society for Bipolar Disorders on this topic; and Professor Ross J. Baldessarini, MD, Director of the International Consortium for Bipolar & Psychotic Disorders Research of the Mailman Research Center at McLean Hospital in Belmont, Mass..

By «chance» Tomasetti meant the roll of the dice that each cell division represents, leaving aside the influence of deleterious genes or environmental factors such as smoking or exposure to radiation.

These pathways are associated with exposures in childhood, and amplified by factors in adulthood, according to a cohort study published in The Lancet Respiratory Medicine journal.

This can be provoked by a number of factors, but one of the clearest is exposure to death - related imagery.

Indeed, exposure of the protein produced by the nanoparticle - based gene therapy to the gut mucosa prevents inhibitor development and restores clotting - factor activity in mouse models of both haemophilia A and B. «This approach really could hold big benefit for patients,» says Jörg Schüttrumpf, a transfusion - medicine specialist who led one of the studies performed at the German Red Cross Blood Donor Service in Frankfurt.

While the biological mechanism by which exposure to pollution causes lower birth weights are not fully understood, the scientists speculate that several factors could play a role, including maternal inflammation, altered placental function, and reduced nutrient delivery to the fetus, which may impede fetal growth.

Lupus is considered a genetic disease and is triggered not only by inhaling crystalline silica toxicants, but also by other environmental factors such as sun exposure.

Because most cases of Parkinson's disease appear to be at least partially caused by environmental factors such as pesticide exposure, these findings support the approach that targeting α - synuclein could slow or stop the progression of Parkinson's in most people with the disease, said study lead author Jeff Bronstein, a professor of neurology and director of movement disorders at the David Geffen School of Medicine at UCLA.

In addressing the first question, the study showed that the brain's immune cells, microglia, which are known to become activated by LPS exposure as well as in most brain injuries and diseases, begin spewing out pro-inflammatory factors that change astrocytes» behavior.

«By studying these families we could determine multiple - generational exposure to nutritional factors and genetic interactions that occur due to famine.»

«But these single factors don't paint a comprehensive picture of what a person is exposed to in their environment — and may not be as helpful in predicting cancer risk, which is impacted by multiple factors including the air you breathe, the water you drink, the neighborhood you live in, and your exposure to myriad toxins, chemicals and pollutants.»

Environmental mercury and other heavy metal exposure, contaminated water, pesticides, a greater reliance on antibiotics — and even extensive television viewing by very young children — may be factors in mounting autism rates.

For those younger than 30, this exposure is associated with a risk increased by a factor of 7.7.17

Myriad control switches help to arbitrate how genes get expressed in different cells and tissues, and those switches are often triggered by maternal diet, toxic exposures and many other environmental factors.

Scientists are still trying to explain how this microbial diversity comes about, but it is likely influenced by factors including diet, environment, host genetics and exposure to microbes early in life.

New genetic tests being developed by companies provide the hope that eventually people who are genetically predisposed to schizophrenia can be identified before hand - which would then allow families the knowledge that allows them to minimize exposure to the environmental factors associated with schizophrenia — so as to minimize the number of people who actually develop the disorder.

ref Damage may also be driven by disturbance history, level of coral cover, type of coral community, and environmental factors such as exposure and circulation.

Here we have identified another source of human cells that can be efficiently reprogrammed into human iPS cells by the ectopic exposure of only two factors, namely OCT3 / 4 and KLF4.

We now show that astrocytes generated from the same population of human fetal glial precursor cells, by exposure to either bone morphogenetic protein (BMP) or ciliary neurotrophic factor (CNTF), promote widely divergent outcomes with respect to repairing the injured adult spinal cord.

They'll also be studying the involvement of the immune system in the disease and whether this can be affected by exposure to certain environmental factors, such as the sun.

Although smoking is the main risk factor, adenocarcinoma is also the most common type of lung cancer among lifelong non-smokers, and the risk of lung cancer is increased by 20 to 30 percent by exposure to secondhand smoke.

«There are differences in asthma prevalence in these three groups, so it's important to understand whether these are caused by environmental exposures or by differences in genetic risk factors.»

But some factors might be impairment to the immune response, compounded by exposure to environmental toxins.

But experts suggest that the disorder is likely driven by several factors, including exposure to a traumatic event (like a car crash) and / or exposure to repetitive injuries.

These manufacturers don't factor in exposure to multiple sources, which brings the total amount absorbed by the body, including through the skin and through the lungs, much higher.

So, it is essential that we support our adrenal glands as best we can by either removing or reducing the stressful factors in our lives and our exposure to the offending foods or allergens that cause our immune systems to react.

Glycation is a factor of glucose concentration exposure and time, with more AGEs forming upon longer exposure to higher concentrations of glucose.33 It follows that in a body that is hyperinsulinemic, and a brain that is insulin - resistant, the peripheral hyperinsulinism will inhibit the clearance of soluble Aβ by IDE, thereby causing it to remain in the extracellular space for an extended amount of time, and the functional «hyperglycemia» in the brain will provide an elevated level of glucose — the perfect storm for glycation of Aβ and its aggregation into insoluble plaques.

While there clearly isn't just one cause when it comes to rosacea, the research in combination with my own clinical experience suggests that rosacea is at its root an immunological disorder that is precipitated by a variety of factors, including diet, gut health, and lifestyle factors including skin care and sun exposure.

Heals dry, itchy skin caused by poor diet, skin allergies, chemical exposure or other damaging environmental factors