Sentences with phrase «by gene expression»

Each subtype was classified by gene expression clustering, and showed specific patterns of genetic alterations, particularly for four genes: platelet - derived growth factor receptor alpha (PDGFRA), isocitrate dehydrogenase 1 (IDH1), epidermal growfth factor receptor (EGFR), and neurofibromin 1 (NF1).

Only three genes (TP53, PIK3CA, and GATA3) were mutated in 10 % or more of all tumors; grouping them by gene expression (intrinsic) subtype uncovered a number of subtype - specific events.

Kinetics study on markers of the immune system by gene expression profiling of an in vivo heated tumor.

Indeed, this is true in some cases such as eye color, a characteristic that is determined by gene expression early in development.

The behaviour of all living matter is governed by gene expression, the process by which biological materials such as proteins are made.

Not exact matches

Secretory antibodies in breast milk promote long - term intestinal homeostasis by regulating the gut microbiota and host gene expression

Taylor and colleagues made this discovery by exposing fetal mice to BPA during pregnancy and examining gene expression and DNA in the uteruses of female fetuses.

Results showed that BPA exposure permanently affected the uterus by decreasing regulation of gene expression.

The resulting transcriptional profiles cluster not by postpartum day, but by milk Na: K ratio, indicating that women sampled during similar postpartum time frames could be at markedly different stages of gene expression.

The vaccine can be targeted to the chosen pathogen by using RNA molecules which share sequence identity with the pest's genes and prevents their expression.

The shared patterns of gene expression in the limbs and phallus are generated in part by a common set of noncoding DNA, also called «elements» or «enhancers,» which act to control gene expression in both of these structures, argues a study published October 1 in Developmental Cell.

Scientists at Southern Methodist University, led by Professor and Chair of Biological Sciences Santosh D'Mello, have used RNA - Seq to conduct transcriptome profiling of gene expression changes in dying neurons.

In the new research, the UB scientists found they could reverse those social deficits with a very low dose of romidepsin, which, they found, restores gene expression and function using an epigenetic mechanism, where gene changes are caused by influences other than DNA sequences.

An international team led by researchers with the Lawrence Berkeley National Laboratory (Berkeley Lab) has developed a new technique for identifying gene enhancers — sequences of DNA that act to amplify the expression of a specific gene — in the genomes of humans and other mammals.

«Autism's social deficits are reversed by an anti-cancer drug: Using an epigenetic mechanism, romidepsin restored gene expression and alleviated social deficits in animal models of autism.»

A protein called peroxisome proliferator — activated receptor g co-activator 1 - alpha (PGC1 - alpha) regulates the expression of many genes identified by the researchers.

Volatile release stimulated by volicitin may also depend on the octadecanoid pathway, raising the possibility of cross talk between this molecule and the wound - induced expression of defense genes.

A team of researchers from BWH has tackled this problem by comprehensively analyzing gene expression and protein distribution in human aortic valves obtained from valve replacement surgery.

Messenger RNA (mRNA) serves as an important intermediary during gene expression, by relating the genetic information of DNA to the molecular mechanisms involved in manufacturing proteins.

A single miRNA can ramp down expression of multiple genes — but the number of genes affected by known miRNAs hasn't been determined.

This image shows the metabolic expression of a gene identified by scientists from EPFL in Lausanne and ETH Zürich as being a key player in the development of type 2 diabetes.

By identifying gene expression signatures common to sight, touch and hearing, neuroscientists at the University of Geneva (UNIGE), Switzerland, discovered a sensory «lingua franca» which facilitates the brain's interpretation and integration of sensory input.

A team of scientists led by the University of Birmingham has shown how a common mRNA modification, N6 - methyladenosine (m6A), regulates gene expression to determine the sex of fruit flies.

The overlap in gene expression changes when neural progenitor cells are infected by African or Asian strains of Zika virus.

Gene expression is the process where information stored as DNA is converted (transcribed) by enzymes into related molecules called RNAs, and then into proteins that make up the body's structures and signals.

The most promising chemical — sulforaphane, a naturally occurring compound found in cruciferous vegetables — tamped down glucose production by liver cells growing in culture, and shifted liver gene expression away from a diseased state in diabetic rats.

RNAScope ISH was developed by Advanced Cell Diagnostics (ACD) Inc., initially for studies of gene expression in animal (and especially human) tissues.

«By observing neuronal gene expression in these distinct pathways during development, we detected common patterns, as if an underlying genetic language was bringing them together.»

By blocking the expression of a certain gene in patients, University of Montreal researchers have contributed to the demonstration of great decreases in the concentration of triglycerides in their blood, even in various severe forms of hypertriglyceridemia and regardless of the base values or the treatment the patient usually receives.

Among the historical figures bound by the thematic thread of dna in journalist Sam Kean's new book are Charles Hapsburg, whose weak chin was the result of royal inbreeding, and a group of Arctic explorers who were poisoned by the Vitamin A in polar bear liver, which threw off their gene expression.

The two - step process of TILT — getting sick upon toxicant exposure and failing to get well — may be driven by epigenetic changes, which occur when the environment alters the expression of genes without changing the core DNA code itself.

By tracking activity in almost all the genes of a free - living archaeon — which, like a bacterium, is a prokaryote — Bonneau was recently able to piece together how the genes affected one another's expression, enabling him to map the organism's «control circuit» as if it were a machine.

EPFL biologists and geneticists have uncovered how the circadian clock orchestrates the 24 - hour cycle of gene expression by regulating the structure of chromatin, the tightly wound DNA - protein complex of the cell.

The direct methylation of the DNA changes the gene expression permanently if it takes place in the control regions of genes (so - called CpG islands), that have been made accessible by the modification of the histones.

In a new study published in Physiological Genomics, a team of U.S. researchers tracked in detail how this extreme makeover is controlled by changes in gene expression.

The answer may lie in epigenetics — the mechanism by which environmental influences affect gene expression.

By day 34 of development, however, the pattern of gene expression was much more similar to control cows derived from artificial insemination, suggesting that these surviving clones were able to implant in the uterus and begin to form a placenta.

This means that gene expression can be measured by the amount of each unique type of mRNA found in a blood sample.

The Epstein - Barr virus, which infects some 90 % of Americans, may cause changes in gene expression that dramatically increase a person's chance of getting lupus and six other autoimmune disorders, a new study by Harley, now a rheumatologist at the Cincinnati Children's Hospital Medical Center in Ohio, and colleagues shows.

Prof. Khatri and his team studied the way the immune system responds to infection by looking at gene expression — which genes are active and which are not — and whether there are differences in patients with malaria compared to other infectious diseases.

Four days later, the livers of the non-supressed mice had readjusted to a normal daily rhythm, as revealed by the daily rise and fall of liver - gene expression.

An additional study, currently available at bioRxiv, led by the researchers from the CRG and Cold Spring Harbour Laboratory, highlights the fact that a substantial part of human and mice genes have maintained an essentially constant expression throughout evolution, in tissues and various organs.

Sure enough, plant root cells that harbor fungal arbuscules increase their expression of genes involved in producing such lipids by 3000-fold.

They did this by testing tissue concentrations of fatty acids in liver, muscle and brain tissue, along with the expression of genes involved in regulating EPA status and its physiological benefits.

«This could mean that the reversal or suppression of pathological gene expression by beta blockers is somehow protective against heart failure, but it's something we would need to look into further to understand how individual genes function in the heart.»

«It is exciting to find a correlation between brain circuitry and gene expression by combining high quality data from these two large - scale projects,» says David Van Essen, Ph.D., professor at Washington University in St. Louis and a leader of the Human Connectome Project.

W: We should have gene expression and big projects organized by the National Institutes of Health, and they're not doing anything.

Despite the anatomical complexity of the brain and the complexity of the human genome, most of the patterns of gene usage across all 20,000 genes could be characterized by just 32 expression patterns.

Then they compared the expression of thousands of genes in two samples by measuring levels of messenger RNA.

An antisense - based treatment called nusinersen, which removes a roadblock in the expression of the second SMN gene, was recently approved by the FDA.