Sentences with phrase «by gene expression profiling»

Kinetics study on markers of the immune system by gene expression profiling of an in vivo heated tumor.

Not exact matches

The resulting transcriptional profiles cluster not by postpartum day, but by milk Na: K ratio, indicating that women sampled during similar postpartum time frames could be at markedly different stages of gene expression.

Scientists at Southern Methodist University, led by Professor and Chair of Biological Sciences Santosh D'Mello, have used RNA - Seq to conduct transcriptome profiling of gene expression changes in dying neurons.

By combining salivary gene expression profiles, postconceptional age and sex, this predictive model not only assessed the probability of feeding success, but also, and most importantly, highlighted specific developmental pathways that were likely contributing to feeding immaturity.

A new effort by DOD, NCI, and the Department of Veterans Affairs will profile gene and protein expression in thousands of individuals» tumors.

Researchers from BUSM and the University of Cyprus compared the markers on the surface of the cancer cells to gene expression profile of breast tumors deposited by researchers in international public databases and found that a molecule named IL13RA2 (IL13R alpha2) was abundant in metastatic or late - stage BLBC.

Microbiota or microbiome structure, gene expression, and metabolism were assayed by 16S ribosomal RNA profiling, whole - community shotgun sequencing, RNA - sequencing, and mass spectrometry.

The researchers comprehensively analyzed 254 TCGA lower - grade gliomas for gene, protein and micro RNA expression, DNA methylation and gene copy profiles to cluster cases by category.

«These findings raise the possibility that by determining the gene expression profile of a patient's tumor, physicians may be able to identify aggressive disease at the outset of diagnosis and start treatment earlier,» said Sungyong You, PhD, an instructor in the Cedars - Sinai Department of Surgery and the first author of the study.

The researchers identified the LSC17 score by sampling the leukemia stem cell properties of blood or bone marrow samples from 78 AML patients from the cancer centre combined with molecular profiling technology that measures gene expression.

This single cell transcriptome analysis followed by computational analyses enabled the team to identify the gene expression profiles of cells in the process of changing from ES cells to 2CLCs.

The case for direct interaction was bolstered by similarities between gene expression profiles of plants with various deficiencies in photoreceptors and COP1.

While expression levels of all marker genes remained almost unchanged in wild - type ACVR1 cultures compared with the empty viral vector, the expression profile induced by caACVR1 Q207D displayed evidence of advanced chondrogenic differentiation as shown by decreased levels of the early differentiation stage marker collagen type II together with enhanced expression of the later - stage markers Ihh and collagen type X. Indian hedgehog has been shown previously to be induced by BMP signaling transmitted via the ACVR1 receptor (9).

Analysis of gene expression profiles can be carried out by the users, or by the facility.

By looking at the gene expression profile in single cells, the researchers were able to identify previously unknown transient states that typified the progression from precursor to more - specialized cells.

This will be achieved by exposing the coral to seawater with high calcium concentrations to induce an alteration in gene expression profiles, identified using a DNA microarray analysis.

In this study we have explored the gene expression profile and signaling pathways followed by the calcification process of a basal metazoan, the Red Sea scleractinian (stony) coral, Stylophora pistillata.

Calcification rate measurements and gene expression analysis by microarray RNA transcriptional profiling at two time - points (midday and night - time) revealed several genes common within mammalian gene regulatory networks.

To better understand this complex tissues and its functions — and the diseases that affect it — a multicenter team led by researchers at the Broad Institute of MIT and Harvard and Massachusetts General Hospital has released a census of the cells that make up the lining of the small intestine, using gene expression profiles of more than 53,000 individual cells from the mouse gut or gut organoid models.

Unfortunately, direct comparisons of gene expression profiles obtained in independent, publicly available microarray experiments are typically compromised by substantial, experiment - specific biases.

PHOTO: Harbour LaboratoryUsing very small amounts of tumor tissue collected by a needle biopsy, doctors can conduct gene expression profile testing to determine the likelihood that an ocular melanoma tumor will spread beyond the eye.

For example, mutants may be characterized by comparing their transcript profiles to those obtained in other experiments querying the effects on gene expression of many experimental factors including treatments, mutations and pathogen infections.

Melanocytes respond by altering gene transcription, and these changes in gene expression profiles result in easily quantifiable phenotypes such as modified pigment production (a hallmark of melanocyte differentiation state) and changes in morphological cell properties.

Halotolerant Exiguobacterium profundum PHM11 Tolerate Salinity by Accumulating L - Proline and Fine - Tuning Gene Expression Profiles of Related Metabolic Pathways — Vikas K. Patel — Frontiers in Microbiology

In sensory pathways, gene expression profiles are modified by age

Then we tested functionality of oocytes matured in vitro by assessing the ability to develop to the blastocyst stage, and by comparing the gene expression profiles of parthenogenic embryos and those obtained from IVF / ICSI.

Gene expression profiles measured using human genome Affymetrix Gene Chip arrays were grouped by hierarchical clustering, and correlation coefficients were computed for all pair-wise comparisons (Fig. 4A).

Approximately 50 % of PTCL are unclassifiable and categorized as PTCL, not otherwise specified (PTCL - NOS).1 Using gene expression profiling, PTCL - NOS lymphocytes can be distinguished from normal T lymphocytes, with deregulation of genes involved in apoptosis, proliferation, cell adhesion, and transcription regulation.2 Two subgroups of PTCL - NOS have been identified, which are characterized by high expression of either GATA3 or TBX21 / T - bet transcription factors and downstream target genes.3 However, actionable biomarkers closely related to the pathogenic mechanism need to be further investigated and may become potential therapeutic targets of PTCL - NOS. 4, 5

Comparison of gene expression profiles obtained by Q - PCR (left panels) and microarray analysis (right panels).

Their gene expression analysis throughout the protocol matched that of a previously published profile for hESCs [24], which included the significant upregulation of mesodermal and chondrogenic markers (PDGFRB, SOX6, SOX9, ACAN, COL2A1 types A and B), with the more mature COL2A1 type B splice variant [42] being more highly expressed by the end of stage 3.

The FunGenES consortium collected gene expression profiling data from mouse ES cells in a coordinated fashion by streamlining techniques and standardizing experimental protocols among partners.

The resemblance of gene expression profiles between SCNT - derived blastocysts and those derived by artificial insemination (AI)(18) was the first evidence that the effects of cloning by SCNT could be more severe after blastocyst hatching.

Based on the gene expression profile, we demonstrated the up - regulation of hormone sensitive lipase and enhancement of the lipolytic activity by the treatment of adipocytes with C3G or Cy.