«Our attempts to determine the causes behind the disorder were greatly aided
by gene sequencing technology and biocomputational analysis,» adds Dr. Knierim.
Not exact matches
Using
gene -
sequencing technology, researchers established that the precise segment of the pup's DNA «switched on»
by the act of grooming was the part that controlled the future function of the hippocampus, which processes stress hormones.
Gene discovery was greatly facilitated
by a new exome
sequencing technology, which analyzes all protein - coding regions of the genome at once.
CRISPR - Cas9 is a versatile and highly accurate
gene - editing
technology that allows researchers to modify specific parts of an organism's genome
by altering sections of the DNA
sequence.
The latest
gene -
sequencing technologies developed
by biotech companies 454 Life Sciences and Illumina can analyze several million DNA fragments at a time.
«Single - nucleus RNA
sequencing, droplet
by droplet: DroNc - Seq,
technology that merges single - nucleus RNA
sequencing with microfluidics, brings new scale to
gene expression studies in complex tissues.»
Using sophisticated genetic
sequencing technology, King and Yin identified a common set of
genes that are controlled
by a shared network of genetic regulators known as microRNAs.
By using random series of 30 nucleotides — the building blocks of RNA and DNA — he thought he could give neurons unique barcodes, linking the barcodes across synapses, then create maps of their connections using high - throughput
gene sequencing technology.
The convergence of several factors explains the trend: cheaper genetic
sequencing technologies, the discovery of new oncogenes (
genes that can cause a normal cell to become cancerous), a new generation of computers and bioinformatics that can analyze vast amounts of data, and a multibillion - dollar effort
by researchers inside and outside the pharma industry to develop targeted drugs and companion diagnostics for cancer.
Meanwhile,
gene -
sequencing technology has progressed
by leaps and bounds, becoming far cheaper in the process.
In the lead profile, Jansson represented those researchers investigating such diseases
by using omics
technologies - uncovering the DNA
sequences, expressed
genes, and metabolite signatures used to reveal links to microbial functions in the gut.
The SIGMA project aims to develop novel biomedical approaches to treat this devastating disease
by applying powerful
sequencing technologies to discover the
genes and key pathways underlying common varieties of cancer.
The advent of RNA - seq
technology, in conjunction with full genome
sequencing, provides a method for the unbiased characterization of
genes regulated
by infection in almost any species that can be manipulated in the laboratory.
Thanks to innovations in
sequencing technology that have produced a cornucopia of genomes, plus some tweaks to the computational methods
by different labs, the combined list of identified HARs now includes nearly 3,000 genome segments.4 But the original trend still holds; nearly all HARs are outside
genes, some quite far away from any
gene in the genome.
DNA
sequencing technology using off - the - shelf equipment devised
by George M. Church at Harvard Medical School and collaborators at Harvard and Washington University in St. Louis may help realize the federal goal of reducing that price to $ 1,000
by 2015, which experts say would make it practical to decode an individual's
genes for routine medical purposes.