Sentences with phrase «by gene studies»

Not exact matches

June 19, 2013 — A Cornell University study offers further proof that the divergence of humans from chimpanzees some 4 million to 6 million years ago was profoundly influenced by mutations to DNA sequences that play roles in turning genes on and off.

Richard Dawkins likened memes to genes, but a new study by Facebook shows just how accurate that analogy is.

The Strategy of the Genes: A Discussion of Some Aspects of Theoretical Biology (London: Allen and Unwin, 1957); Hardy, Sir Alister, The Biology of God: A Scientist's Study of Man the Religious Animal (New York: Taplinger Publishing Company, 1976); by the same author, The Living Stream: A Restatement of Evolution and its Relation to the Spirit of Man (London: Collins, 1965), and The Divine Flame: An Essay Towards a Natural History of Religion (London: Collins, 1966), Vols.

Having looked at the Reiner and Meyer studies, we in the Johns Hopkins Psychiatry Department eventually concluded that human sexual identity is mostly built into our constitution by the genes we inherit and the embryogenesis we undergo.

After finishing the survey, participants in the study can opt for an additional study and consider submitting DNA collected by a cheek swab to be tested for variants at the Apolipoprotein E (APOE) gene.

Findings from a study into Crohn's disease, led by William G. Kerr, Ph.D., of SUNY Upstate Medical University, and his collaborators at the Erasmus Medical Center in the Netherlands, provide the first evidence that patients with debilitating inflammatory bowel disease lack sufficient quantities of a protein that comes from the SHIP1 gene.

Interestingly, this study demonstrated that Igfr2, the first imprinted gene discovered by Denise Barlow in 1991, is surrounding by a large cluster of imprinted genes that extend over 10 % of the chromosome, making it the largest co-regulated domain in the genome outside of the X chromosome.

The shared patterns of gene expression in the limbs and phallus are generated in part by a common set of noncoding DNA, also called «elements» or «enhancers,» which act to control gene expression in both of these structures, argues a study published October 1 in Developmental Cell.

McCallion's strategy to make sense of all this data looks at the active genes in cells affected by a disease, groups of genes that interact with one another, their vulnerability to mutation and information from past scientific studies to filter more than a thousand gene candidates for disease risk down to just a handful within any one implicated region.

The study, led by Dr Len Stephens and Dr Phill Hawkins and published today in the journal Molecular Cell, reveals why loss of the PTEN gene has such an impact on many people with prostate cancer, as well as in some breast cancers.

The study identified yet another mutation — albeit a rare one — in the SCARB1 gene, also associated with elevated HDL levels, that raised coronary heart disease risk by a whopping 80 percent.

A genetics research team at Johns Hopkins Medicine has solved a dilemma facing researchers who use genomewide association studies (GWAS) by developing a new approach that strategically «filters» which genes are worth further study.

Jiang said autism researchers worldwide could use the mouse model to study ways to compensate for the gene and improve symptoms in people with autism spectrum disorders and Phelan - McDermid Syndrome, a more profound developmental condition caused by mutations to SHANK3 and other genes in chromosome 22.

She latched onto the SCARB1 gene, inspired by a 2002 study in which MIT molecular biologist Monty Krieger found that mice engineered to lack that gene were more prone to heart attacks.

The UNC collaborators on the study team, led by Timothy C. Nichols, MD, performed gene therapy experiments using the well - established dog colony at their institution.

In the new study, Duke University researchers overcame several of these obstacles by using a non-pathogenic carrier called adeno - associated virus, or AAV, to deliver the gene - editing system.

The study, which is published in the journal Molecular Psychiatry, describes a possible mechanism for how the gene variant produces clinical symptoms by affecting levels of specific proteins in the brain.

For the study, the researchers created a line of zebrafish with defective immune systems by inserting a mutation into a gene required for development of an important component of the immune system.

In a 2016 study, Yang, Gomez - Pinilla and colleagues reported that hundreds of genes can be damaged by fructose and that an omega - 3 fatty acid called docosahexaenoic acid, or DHA, seems to reverse the harmful changes produced by fructose.

Since then, Pereira - Smith's team has moved into using genetic techniques in mice to study whether and how senescence is regulated by MORF4 and related genes.

The study found that in the 18th and 19th centuries, about four to 18 per cent of the variation between individuals in lifespan, family size and ages at first and last birth was influenced by genes, while the rest of the variation was driven by differences in various aspects of their environment.

Led by researchers at the Cincinnati Children's Hospital Medical Center Heart Institute, the study demonstrates the gene Gm7325 and its protein — which the scientists named «myomerger» — prompt muscle stem cells to fuse and develop skeletal muscles the body needs to move and survive.

A previous study authored by Millay in 2014 identified myomaker and its gene through bioinformatic analysis.

Note added in proof: Additional evidence for CA1 - CA3 differences is provided by a recent study measuring immediate early gene activation in two different novel rooms (36).

Data published by the International Human Genome Sequencing Consortium indicate that somewhere between 113 and 223 genes present in bacteria and in the human genome are absent in well - studied organisms — such as the yeast Saccharomyces cerevisiae, the fruit fly Drosophila melanogaster and the nematode Caenorhabditis elegans — that lie in between those two evolutionary extremes.

RNAScope ISH was developed by Advanced Cell Diagnostics (ACD) Inc., initially for studies of gene expression in animal (and especially human) tissues.

Complex traits like the ones in the study are each influenced by many different genes, while at the same time, several different traits can be affected by the same genes.

As Saaïd Safieddine, CNRS Director of Research at the Institut Pasteur and co-senior author of the study with Prof. Christine Petit (head of the Genetics & physiology hearing unit at the Institut Pasteur), explains, «we have just shown that it is possible to partially correct a specific form of hereditary hearing loss accompanied by balance problems using local gene therapy performed after the embryogenesis of the ear, which is primarily affected by the mutation responsible for the disorder.

A study published June 1 by Nature Communications reports scientists identify a new gene essential to this process, shedding new light on possible new therapeutic strategies.

In patients with anorexia nervosa, the study indicates that the increase in sweating experienced when viewing images of thin bodies is explained by the presence of a specific form (allele) of the gene in question.

Yang said the study not only indicated which genes are affected by traumatic brain injury and linked to serious disease, but also might point to the genes that govern metabolism, cell communication and inflammation — which might make them the best targets for new treatments for brain disorders.

A new multi-institutional study by Japanese researchers shows a potential rare gene mutation that could act as a predictor for two neurodevelopmental disorders, schizophrenia and autism.

By studying these relationships, the researchers have discovered a new pathway to identify how genes influence disease, according to Boerwinkle.

Changes in key genes clearly define four previously unknown conditions within the umbrella diagnosis of schizophrenia, according to a study led by researchers from NYU Langone Medical Center published online April 28 in EBioMedicine, a Lancet journal.

In a new study published in Physiological Genomics, a team of U.S. researchers tracked in detail how this extreme makeover is controlled by changes in gene expression.

A study published last year by the same team lay the foundation for the current EBioMedicine publication by defining the framework for finding influential genes.

These results can also be used by researchers studying the genetic underpinnings of mental disorders, as they indicate that the same genes might be associated with increased risk for various psychiatric disorders.»

The Epstein - Barr virus, which infects some 90 % of Americans, may cause changes in gene expression that dramatically increase a person's chance of getting lupus and six other autoimmune disorders, a new study by Harley, now a rheumatologist at the Cincinnati Children's Hospital Medical Center in Ohio, and colleagues shows.

Studying three groups of flies, the scientists interfered with their ability to remember by disabling a different critical memory gene in each group.

Most of the rechristened genes were identified by geneticists studying the fruit fly; when equivalent genes were later found in the human genome, researchers simply continued using the name of the fruit fly gene to avoid confusion.

Prof. Khatri and his team studied the way the immune system responds to infection by looking at gene expression — which genes are active and which are not — and whether there are differences in patients with malaria compared to other infectious diseases.

An additional study, currently available at bioRxiv, led by the researchers from the CRG and Cold Spring Harbour Laboratory, highlights the fact that a substantial part of human and mice genes have maintained an essentially constant expression throughout evolution, in tissues and various organs.

Further molecular biological studies by the scientists demonstrated that methylation in the non-coding region of the Igfbp2 gene contributes to less IGFBP2 synthesis.

A second study published in Biological Psychiatry, also led by Dr. Perlis, applied the new method in a proof - of - concept study to identify genes associated with psychiatric symptoms.

A study in the journal Nature reports the discovery of rapid - growth genes in rice varieties that can withstand flooding by quickly rising above the new water line.

«Phenocopy can be caused by other risk - modifying genes or exposure patterns that increase the probability of the specific phenotype manifesting itself,» says the study's first author Hildur Helgadottir, researcher at Karolinska Institutet's Department of Oncology - Pathology, Stockholm, Sweden.

The result was the largest deletion ever observed in the dystrophin gene using CRISPR / Cas9, and the study was the first to create corrected human iPS cells that could directly restore functional muscle tissue affected by Duchenne.

The two studies together suggest that single copies of inactivating ANGPTL3 mutations are found in roughly one of every 250 people of European descent, whereas people with mutations in both copies of the gene — as in the family studied by Musunuru and colleagues — are much rarer.

But he wanted the convention to call for greater transparency in how the technology is studied in labs and deployed in the field, for instance by creating a mandatory gene - drive registry.

The study was designed by Robert Plomin of the Institute of Psychiatry at King's College London and his colleagues, to tease apart the impact of genes and the environment on educational achievement.