Sentences with phrase «by gene variants»

Slow - healing or non-healing bone fractures in otherwise healthy people may be caused by gene variants that are common in the population, according to Penn State College of Medicine researchers.

It's caused by a gene variant that makes too little LPH, an enzyme that breaks down lactose.

Not exact matches

Mostly they are optimists, excited by the latest findings: the newly isolated gene variant that may help explain schizophrenia, the new telescopic images that reveal the violent births of distant....

After finishing the survey, participants in the study can opt for an additional study and consider submitting DNA collected by a cheek swab to be tested for variants at the Apolipoprotein E (APOE) gene.

These are subjected to so - called next generation sequencing, a technique that sifts the vast genetic composite, ferreting out sequence variants (or alleles) caused by mutations in genes.

The study, which is published in the journal Molecular Psychiatry, describes a possible mechanism for how the gene variant produces clinical symptoms by affecting levels of specific proteins in the brain.

Genes also play a role in menopause, and two research teams have identified several gene variants associated with advancing or delaying menopause by as much as two years.

An apparently new Variant of human serum albumin, albumin Naskapi, has been found in high frequency in the Naskapi Indians of Quebec and, in lower frequency, in other North American Indians.The family and population data of the albumin are consistent with its inheritance as a simple autosomal trait Controlled by a gene designated Al Naskapi.

That does not mean that breeders could create a 200 - pound Chihuahua by swapping the small IGF1 variant for another, she says, because multiple genes work together to shape a breed's traits, including its size.

Humans are still evolving and producing new gene variants, and one of them may give protection against becoming addicted to alcohol - by stopping us drinking altogether

By collaborating with Konrad Oexle and colleagues from the Institute of Neurogenomics at the Helmholtz Zentrum, München, Germany, the researchers could conclude that the genetic variants in the gene seem to contribute to all three disorders.

It comes out in support of a ruling in March by a lower court that the patents, owned by biotech firm Myriad Genetics, should be revoked because they cover gene variants identical to ones that can be found naturally in women.

Earlier this year, he and colleagues reported that a gene variant that tweaks people's sensitivity to growth hormone also boosts lifespan by about 10 years — although only in men.

Last week, Nature reported that Pier Valerio Reinotti, an appeal court judge in Trieste, Italy, cut Bayout's sentence by a year after finding out he has gene variants linked to aggression.

In several groups of people, a gene variant allowing the lactase, the enzyme breaking down the sugar in milk, to persist into adulthood became common about 5000 to 7000 years ago, when humans were herding cattle — as evidenced by this rock painting of domestic cattle in the Jebel Acacus region of the Sahara desert in Libya.

By 12 months of age, infants with this gene variant whose needs were consistently attended to responded to stress just as effectively as did the babies with other versions of the gene.

By splicing the scrambled genes into Escherichia coli bacteria and growing the new strains in colonies, he and his colleagues identified variants that glow like GFP.

Lo was encouraged by the variants because retroviruses are extremely mutable pathogens that change their gene sequences again and again in response to immune system efforts to kill them.

More than one quarter of children with two copies of a high - risk variant in a specific group of genes develop an early sign of celiac disease called celiac disease autoimmunity (CDA) by age 5.

By characterising the DNA sequence of these individuals, the project gained insight into the contribution of rare variants to a broad range of disease scenarios, and discovered new genetic variants and genes underpinning disease risk.

The study, which has identified more than 200 rare variants inherited by children, determines that genes YWHAZ and DRP2, among others, are new candidates in the research on autism genetic basis.

By comparing the genome of these three variants, Di - Poï and Milinkovitch have discovered the gene affected by this mutatioBy comparing the genome of these three variants, Di - Poï and Milinkovitch have discovered the gene affected by this mutatioby this mutation.

«Using a technique developed by our collaborators at the University of Iowa, we were able to get long - term expression of these human gene variants in the fluid that bathes the entire brain,» says Bradley Hyman, MD, PhD, of the MassGeneral Institute for Neurodegenerative Disease (MGH - MIND), senior author of the report in the Nov. 20 Science Translational Medicine.

Instead, gene variants will need to be introduced by hybridization with other diverse strains of S. cerevisiae, says Borneman, such as those found in natural fermentations of African palm wine and other environmental isolates.

Their analysis — which used DNA data from a Neandertal woman from the Altai Mountains in Siberia (SN: 1/25/14, p. 17) and 112,338 present - day British people — confirmed some links between Neandertal heritage and human diseases made by previous studies (SN: 3/5/16, p. 18), but didn't find evidence that Neandertal gene variants contribute to obesity.

In the work presented here, we were able to show that stress — represented by financial hardship — led to an increase in migraine in those who have a particular gene variant.

Neanderthal genetic material is found in only small amounts in the genomes of modern humans because, after interbreeding, natural selection removed large numbers of weakly deleterious Neanderthal gene variants, according to a study by Ivan Juric and colleagues at the University of California, Davis, published November 8th, 2016 in PLOS Genetics.

He was also missing the Alzheimer's susceptibility allele apo, a well - established variant of a gene for apolipoprotein E carried by approximately two out of three patients.

A variant of a gene that protects us against alcohol addiction, possibly by making boozing intolerable, seems to be favoured by evolution.

Moreover, disease - causing variants in DNA often do not act directly, but by activating nearby genes.

The audience will learn about the current state of breast cancer research, how data generated by NGS gene panels target variants of interest and have been developed and used in routine laboratory research, and the broader issues of breast cancer education, awareness, and community services.

Mice prefer the smell of other mice with different variants of MHC genes to their own and tend to confirm this preference by mating with mice possessing dissimilar MHC genes.

And even if such a demand existed, there was no evidence that genetic counseling could help patients with psychiatric disorders, which — like most of the more common diseases — are caused by a complex interplay of multiple genes and variants as well as environmental factors.

Now, to enable widespread gene delivery throughout the central and peripheral nervous systems, Caltech researchers have developed two new variants of a vector based on an adeno - associated virus (AAV): one that can efficiently ferry genetic cargo past the blood - brain barrier; and another that is efficiently picked up by peripheral neurons residing outside the brain and spinal cord, such as those that sense pain and regulate heart rate, respiration, and digestion.

But he adds that genes are «team players,» and that SNVs that are benign in isolation could cause disease when accompanied by other detrimental variants.

«MARRVEL helps to facilitate analysis of human genes and variants by cross-disciplinary integration of 18 million records so we can speed up the discovery process through computation,» Liu said.

One difficulty in studying the genetics of common mental illnesses is that they are generally caused by environmental factors in combination with multiple gene variants, any one of which usually could not by itself cause disease.

MacArthur's team calculated how many variants each gene should have if those changes arise by chance.

With this knowledge we can not only improve yield and quality but also improve animal health by identifying pathogenic gene variants and ensuring that they are not passed on to future animals.»

«Since our study only looked at common gene variants, the total genetic overlap between the disorders is likely higher,» explained Naomi Wray, Ph.D., University of Queensland, Brisbane, Australia, who co-led the multi-site study by the Cross Disorders Group of the Psychiatric Genomics Consortium (PGC), which is supported by the NIH's National Institute of Mental Health (NIMH).

So gene variants that have been selected for are often found surrounded by the same stretches of DNA, whereas those that have not been selected do not have consistent genetic neighbours.

Fugger says it is unclear how TNF influences MS, but in patients with the gene variant, the TNF - blocking drugs could be providing a double - whammy by suppressing TNF signalling further.

Thomas and his colleagues began this study by searching for other possible IFITM3 variants that correlated with gene expression, levels of the IFITM3 proteins and were common in flu patients in the U.S..

For instance, when the researchers removed the possible confounding influence of ApoE4 by looking only at families lacking that ApoE variant, they found that the frequency of the mutant A2M gene in Alzheimer's patients was four times greater than in their siblings who did not have the disease.

This is the prospect raised by the discovery of gene variants that seem to predict whether an individual will produce enough antibodies in response to a vaccine to protect them against disease.

A rare gene variant discovered by UCL (University College London) scientists is associated with an increased risk of developing schizophrenia, bipolar disorder and alcoholism, confirms new research.

First, autism may not be rigidly determined but instead may be related to common gene variants, called polymorphisms, that may be derailed by environmental triggers.

The effects of this previously discovered gene variant were analysed by utilising data from the unique and extensive METSIM study.

Now, a study led by a researcher at the Salk Institute has found that variants of a single gene can largely determine a plant's ability to thrive in environments where iron is scarce.

Researchers suspect an autoimmune reaction is to blame because many people who develop narcolepsy — and just about everyone with the vaccine - associated form — have a specific variant in a gene in the HLA family, which helps the body distinguish its own proteins from those made by microbial invaders.