Sentences with phrase «by genome analyses»

«Leprosy's drug resistance and origin revealed by genome analysis.»

An important model in studying human disease, the non-coding RNA of the canine genome is an essential starting point for evolutionary and biomedical studies, according to a new study led by The Genome Analysis Centre (TGAC).

Not exact matches

By increasing the speed and accuracy for NGS data analysis like whole genome sequencing (WGS), our computing platform makes it easier to discover links between DNA sequence variations and human disease.»

Their analysis of data in previous studies done by The Cancer Genome Atlas group have shown that the types of abnormal methylation levels they found are lower in smokers who have quit for more than 10 years than those who have not quit.

An analysis of the cat genome led by researchers at Washington University School of Medicine in St. Louis reveals some surprising clues.

The work carried out by Dr Casewell and his co-authors was used in the second paper outlining the analysis of the genome of the Burmese python, also published in the same edition of PNAS.

Producing a short list of strong candidates was in itself a feat, accomplished by applying the right filters to analysis of human and chimpanzee genomes, said co-author Gregory Wray, professor of biology and director of the Duke Center for Genomic and Computational Biology.

Fully sequenced genomes remain rare, so the bulk of the analysis was done by looking at genetic markers known as single nucleotide polymorphisms or SNPs.

In - depth analysis of the human body's microflora has been possible only in the past few years — a by - product of the same new gene sequencing techniques that have allowed scientists to cheaply and accurately identify the DNA of the human genome.

These genomic variations have been revealed by studies in the population and by analysis of the genomes of colon cancer patients that are available in data bases such as that of the 1000 Genomes Projecgenomes of colon cancer patients that are available in data bases such as that of the 1000 Genomes ProjecGenomes Project Data.

Among other initiatives, his group contributes to ENCODE (Encyclopedia of DNA Elements), supported by NIH to define functional genomic elements; the DOE Systems Biology Knowledgebase (KBase) for data sharing and analysis; and the internationally funded 1000 Genomes Project on human genetic variation.

Intact genomic DNA (gray) and genomic DNA digested by LbCpf1 (blue), AsCpf1 (red) or SpCas9 (yellow) weresubjected towhole - genome sequencing and Digenome - seq analysis.

Before the consortium came together, he had participated in sequencing the genomes of two vocal learners, a songbird and a parrot, but he knew he couldn't do all of the additional sequencing and analysis work that would be required to identify genes related to vocal learning — not by himself, at least — so he teamed up with Genome 10K, a project aiming to collect genomes for 10,000 vertebrate species.

Careful attention to phenotyping diseases, facilitated by our knowledge of the human genome and computational analysis, has allowed observant physicians and physician - scientists to identify and categorize diseases in a manner that has informed basic science, given it new contexts, and in many instances provided important new directions for investigation.

This groundbreaking research included an analysis of the Pandoravirus salinus proteome, which proved that the proteins making it up are consistent with those predicted by the virus» genome sequence.

A comparative analysis of genomes by the international consortium also revealed that the organisation of the coffee tree genome is best preserved in the Asteridae (the family to which potatoes and tomatoes belong) and is very close to that of the ancestral species from which all true Dicotyledons (or Eudicotyledons) descended through evolution.

To identify the genes that give rise to the palette of human skin tones, Crawford et al. applied genome - wide analyses across diverse African populations (see the Perspective by Tang and Barsh).

New research led by Li Ding, Ph.D., of Washington University School of Medicine in St. Louis, shows that current approaches to genome analysis systematically miss detecting a certain type of complex mutation in cancer patients» tumors.

Researchers who participated in the research are: Bru Cormand, Claudio Toma, Bàrbara Torrico and Alba Tristán, from the Department of Genetics and the Institute of Biomedicine of the University of Barcelona (IBUB), affiliated centres with the campus of international excellence BKC; Concepció Arenas (Department of Statistics of the UB) and Mònica Bayés, researcher from the National Centre for Genome Analysis (CNAG), located at the Barcelona Science Park (PCB - UB), and the groups led by Amaia Hervás, coordinator of the Child and Adolescence Mental Health Unit at the Mutua de Terrassa University Hospital, and Marta Maristany, from Sant Joan de Déu University Hospital, affiliated centres with the campus of international excellence HUBc.

The analysis suggests that the degree of T - cell clone sharing between twins is greater than can be explained simply by shared genomes.

On 20 December 2013, a paper by the Amborella Genome Sequencing Project that includes a full description of the analyses performed by the project, as well as implications for flowering plant research, will be published in the journal Science.

The researchers, including postgraduate students Miaolin Chen at Shanghai Jiao Tong University and Deborah Devis at the University of Adelaide's Waite campus, performed a genome - wide analysis of potential pollen allergens in two model plants, Arabidopsis thaliana (thale cress) and rice by comparing those results among 25 species of plants ranging from simple alga to complex flowering plants.

Conducting the first large - scale, genome - wide analyses of ancient human remains from the Near East, an international team led by Harvard Medical School has illuminated the genetic identities and population dynamics of the world's first farmers.

To help identify genes and signaling pathways that may be influenced by zinc, Knoell and his team performed a genome - wide microarray analysis of lung tissue taken from zinc - deficient mice with sepsis.

They then used genome - wide analysis to search for genes switched on by KLF4 at a late stage of reprogramming.

The research, which formed part of a vast study carried out over the past four years by the international Avian Phylogenomics Consortium, involved the analysis of the whole genome structure of the chicken, turkey, Pekin duck, zebra finch and budgerigar.

Coral genome analysis conducted by OIST has now showed that this is very unlikely.

«Using the genome data analysis methods developed by co-author Steve Horvath at UCLA, we have uncovered crucial gene networks and we can now predict possible future genetic disorders at the eight - cell stage.»

The commission took a stab at these complicated questions, issuing new analysis and recommendations for how to manage these increasingly complex issues in medicine, research and with direct - to - consumer tests that allow a patient to send in a cheek swab and get health information (like the personalized genome services kit offered by 23andMe, that was recently blocked by the U.S. Food and Drug Administration).

This achievement marks the first big test of a new analysis method that can speed up genome assembly by compressing the raw sequence data 100-fold.

Together, all five RMs serve as a collection of well - characterized, whole genome standards that can tell a laboratory how well its DNA sequencing processes are working by measuring the performance of the equipment, chemistry and data analysis involved.

Another way to glean information from the genome is to check how it is folded — a perfect job for 3D analysis by a computer.

Ewan Birney, 39, of the European Bioinformatics Institute in Cambridge, England, led the analysis by the more than 400 ENCODE scientists who annotated the genome.

Because Kosik's team had information on the genome sequence around the mutation, they could use something called identity - by - descent analysis to determine how the people in the study were related.

It involved the analysis of 5,205 whole genomes from families affected by autism — making it the largest whole genome study of autism to date.

Given the widespread use of the HeLa cell line, Lars Steinmetz and his colleagues at EMBL decided that conducting an extensive analysis of its genome could illustrate the changes caused by cancer — and also help researchers compare versions of the cell line that have evolved over decades of growth in labs around the world.

His analysis was backed up by Nicholson Price, an academic fellow at Harvard Law School in Cambridge, Massachusetts, who found that few, if any, DNA patents would be infringed by companies or clinics sequencing whole genomes of individuals for medical insight.

By probit analysis, the 95 % limit of detection for TMAdV was 781, 377, or 35 viral genome equivalents / mL for serum, stool, or oral swab samples, respectively (data not shown).

But in a new study published online in Nature Genetics, a research team led by J.J. Emerson, assistant professor of ecology & evolutionary biology at the Ayala School of Biological Sciences, applies new methods of genome analysis to identify these complex mutations with unprecedented resolution.

His development of a method for stable transformation of land plant chloroplast genomes, once thought to be impossible, established the field of chloroplast genome engineering in higher plants and has led to an explosion of research concerning the chloroplast genome's role in photosynthesis, functional analysis of plastid genes by reverse genetics, and mechanisms of plastid gene regulation.

Data included community composition by 16S rRNA gene iTag analysis and metaproteomic analysis of partially purified fractions of the community proteome that catalyzed toluene biosynthesis from phenylacetic acid; proteins were identified by mapping peptides to a community metagenome (Joint Genome Institute IMG Taxon ID 3300001784).

The work was led by Professor Michael Wigler of Cold Spring Harbor Laboratory (CHSL), a pioneer in the analysis of genomes and a developer of key technologies that have made such analysis possible, in collaboration with Dennis Vitkup of Columbia University; Dan Levy, Michael Ronemus, Ivan Iossifov and Sarah Gilman of CSHL; and others.

The initial version of CRI iAtlas is based on an analysis performed by The Cancer Genome Atlas (TCGA) Research Network on the TCGA data set comprising over 10,000 tumor samples and 33 tumor samples (Thorsson et al..

«We are also excited that we can now immediately enable individuals to see if they carry such variants, by folding the findings announced today — and others we expect to publish in the near future — into our deCODEme ™ personal genome analysis service.»

The study was led by Director of Science at The Genome Analysis Centre (TGAC) Federica Di Palma.

In a study published online today in Genome Research, scientists developed a new tool to examine genetic differences within bacterial species and uncover novel transmission patterns in mother - infant microbiomes and marine metagenomes not previously appreciated by species - level analyses.

The RD - Connect Genome - Phenome Analysis Platform distinguished as a recognized resource by the International Rare Diseases Research...

Proteomics (Fagerberg et al, «Analysis of the human tissue - specific expression by genome - wide integration of transcriptomics and antibody - based proteomics») with a focus in the article on the tissue - specific pattern in the human body.

Taking advantage of this relevant cell model, we provided, by using a whole - genome transcriptional analysis, a list of DM1 specific biomarkers that could be considered as a robust DM1 signature.

As an example, the ICGC / TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) project, co-led by our group, is leveraging cloud solutions to globally standardize and analyze cancer genomics data, with the aim of uncovering commonalities and differences between molecular disease mechanisms in disparate cancer entities.