The authors found that if they blocked lactate release
by glia or uptake by nerve cells, they produced a long - lasting prevention of cocaine relapse in rodents.
The pain - related LTP is driven not by neuronal activity, but
by glia — nonneuronal cells that protect neurons from injury, among other duties.
Not exact matches
Although the prevailing idea has been that the devastating disease, which strikes some 1 percent of U.S. adults, is primarily caused
by something going wrong with neurons, the scientists suspected the brain's support cells, called
glia.
And research spun out of neuroscientist Linda Watkins's group at the University of Colorado in Boulder is testing a new pain drug that may tame
glia in the spinal cord
by blocking a signaling protein on their surface.
Each cell in the image (both neurons and the support cells known as
glia) was color - coded
by hand, a process that took 150 hours.
A study in the International Society for Stem Cell Research's journal Stem Cell Reports, published
by Cell Press on November 20 shows that a Sox2 protein, alone or in combination with another protein, Ascl1, can cause nonneuronal cells, called NG2
glia, to turn into neurons in the injured cerebral cortex of adult mice.
Rather, Verkhratsky argues, the apparent advantages afforded
by human astrocytes may be a consequence of their housekeeping abilities, underscoring the interdependence between
glia and neurons.
These neurons and the synapses between them are supported
by long, tree - shaped cells called Müller
glia (in green), which may provide a new therapeutic target for treating degenerative eye diseases.
«
By harnessing the lineage tracing methods that are available in the fly, he was able to adapt them to label the
glia and motor neurons that are born from the same stem cell in two different colors.»
Neurons try to avoid this damage
by secreting these lipids, and apolipoproteins — proteins that transport lipids — carry them to
glia cells.
The study published in Cell Metabolism reports a mechanism
by which two types of brain cells, neurons and
glia, normally support each other's functions.
Brain tumors arise in the
glia, or supportive cells, of the brain and now are classified
by their histology — characteristics visible via microscopy — and their cell of origin, either astrocytes or oligodendrocytes.
A new study just published in the journal
Glia and available online on July 11th, details the newly discovered mechanism
by which astrocytes are involved in inhibitory synapse formation and presents strong evidence that Transforming Growth Factor Beta 1 (TGF β1), a protein produced
by many cell types (including astrocytes) is a key player in this process.
Eventually they determined that genes critical to the Müller
glia regeneration were being blocked
by molecules that bind to chromosomes.
One of the team's most exciting new observations suggests a link between autism and a type of neural stem cell called outer - radial
glia (oRGs), discovered
by the Kriegstein lab in 2010.
When researchers at the University of Chicago withdrew exosomes from the blood of rats and administered them to aging animals, the older rats» myelin levels rose
by 62 percent, the team reported in February in
Glia.
«It would be interesting to see if they get the same effects
by engrafting chimpanzee or macaque
glia,» adds evolutionary neuroanatomist Todd Preuss of the Yerkes National Primate Research Center at Emory University in Atlanta.
Currently, we know that
glia become activated in glaucoma, but we do not know
by what process.
Anna Huttenlocher, University of Wisconsin, USA Neutrophils in the Tumor Microenvironment Neutrophils, Wounds, and Cancer Progression Stefan Kaufmann, Max Planck Institute, Germany Pathology and immune reactivity: understanding multidimensionality in pulmonary tuberculosis Constitutive BAK activation as a determinant of drug sensitivity in malignant lymphohematopoietic cells Kathryn Moore, New York University, USA MicroRNA -33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis Lalita Ramakrishnan, University of Cambridge, UK Myeloid Growth Factors Promote Resistance to Mycobacterial Infection
by Curtailing Granuloma Necrosis through Macrophage Replenishment Beth Stevens, Harvard University, USA Microglia: Dynamic Mediators of Synapse Development and Plasticity Do
glia drive synaptic and cognitive impairment in disease?
The symposium is organized
by the Centre for Molecular Biology and Neuroscience (CMBN), University of Oslo, to highlight the emerging importance of the roles of
glia - neuronal interactions in brain function and disease processes.
We propose that the age - related decline in the regenerative behavior of glial cells is caused
by loss of cell - to - cell communication and changes in the internal gene expression of
glia cells.
In essence, neurons and
glia have to repair the damage that is induced
by neuronal activity, injury, toxins, and aging.
(2005) Pressure - Induced Production of Inflammatory Cytokines and Activation of NF B Is Modulated
by Calcium Channels in Retinal
Glia (Investigative Ophthalmology & Visual Science, 46: ARVO E-Abstract 3579).