Sentences with phrase «by high development»

Now a $ 60 billion market for the biotechnology and pharmaceutical sectors, growth of the market has been hampered by high development costs of producing these in animal cell systems, which when factoring in a long period for manufacturing, R&D and clinical trials, may reach around $ 1 billion per each therapeutic candidate.

Not exact matches

The price of oil has risen to its highest since late 2014 this month, driven by concern over the potential for disruption to Iranian crude flows, but analysts say the degree of uncertainty hanging over the deal means the market is extremely sensitive to any developments.

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

This category, defined by Employment and Social Development Canada as covering health, education, social and community services, can include high - level leadership in fields from parks and rec to employment support to public health.

The combined ratio of 97.5 % improved 2.1 points due to higher net favorable prior year reserve development (1.7 points) and a benefit (0.8 points) from catastrophe losses, partially offset by a higher underlying combined ratio (0.4 points).

The combined ratio of 95.5 % decreased 0.5 points due to higher net favorable prior year reserve development (1.0 point), as well as a benefit (0.2 points) from catastrophes, partially offset by a higher underlying combined ratio (0.7 points).

The combined ratio of 97.5 % increased 1.1 points due to a higher underlying combined ratio (1.1 points) and higher catastrophe losses (0.1 points), partially offset by higher net favorable prior year reserve development (0.1 points).

Developers are flocking to the region attracted by the high margins still on offer for major real estate projects, with most developments attracting a return of between 10 - 40 %.

That's one of the findings of a new report published today by the Business Development Bank of Canada, called High - impact firms: Accelerating Canadian competitiveness [PDF].

The development could bring an abrupt end to the high - stakes legal showdown which has become a lightning rod for a broader debate on data privacy in the United States, which was inflamed by revelations in 2013 from former National Security Agency contractor Edward Snowden about the U.S. government's massive surveillance programs.

A study commissioned by the city's economic development authority estimated that the bottom - line benefits of telecommuting for employers, employees and communities across Canada could be as high as $ 53 billion a year.

While the metrics on the white board are different, Coach Dave's words remain eternal: energy (number of hours worked of overtime), effort (percentage of new product developments and revenue streams created by non-Bauer family staff) and desperation (the proportion of our overhead to sales, or how efficient we are in utilizing our capital and labor in our hungry quest for higher profit margins) remain an integral part of the winning formula.

The course is guided by Rob Percival, one of the highest - rated instructors on Udemy, and is a follow up to his original web development course, which was one of the most successful and highly rated on the site.

As head of Export Development Canada, Poloz undoubtedly heard from his share of CEOs hurt by a high loonie.

Actual results, including with respect to our targets and prospects, could differ materially due to a number of factors, including the risk that we may not obtain sufficient orders to achieve our targeted revenues; price competition in key markets; the risk that we or our channel partners are not able to develop and expand customer bases and accurately anticipate demand from end customers, which can result in increased inventory and reduced orders as we experience wide fluctuations in supply and demand; the risk that our commercial Lighting Products results will continue to suffer if new issues arise regarding issues related to product quality for this business; the risk that we may experience production difficulties that preclude us from shipping sufficient quantities to meet customer orders or that result in higher production costs and lower margins; our ability to lower costs; the risk that our results will suffer if we are unable to balance fluctuations in customer demand and capacity, including bringing on additional capacity on a timely basis to meet customer demand; the risk that longer manufacturing lead times may cause customers to fulfill their orders with a competitor's products instead; the risk that the economic and political uncertainty caused by the proposed tariffs by the United States on Chinese goods, and any corresponding Chinese tariffs in response, may negatively impact demand for our products; product mix; risks associated with the ramp - up of production of our new products, and our entry into new business channels different from those in which we have historically operated; the risk that customers do not maintain their favorable perception of our brand and products, resulting in lower demand for our products; the risk that our products fail to perform or fail to meet customer requirements or expectations, resulting in significant additional costs, including costs associated with warranty returns or the potential recall of our products; ongoing uncertainty in global economic conditions, infrastructure development or customer demand that could negatively affect product demand, collectability of receivables and other related matters as consumers and businesses may defer purchases or payments, or default on payments; risks resulting from the concentration of our business among few customers, including the risk that customers may reduce or cancel orders or fail to honor purchase commitments; the risk that we are not able to enter into acceptable contractual arrangements with the significant customers of the acquired Infineon RF Power business or otherwise not fully realize anticipated benefits of the transaction; the risk that retail customers may alter promotional pricing, increase promotion of a competitor's products over our products or reduce their inventory levels, all of which could negatively affect product demand; the risk that our investments may experience periods of significant stock price volatility causing us to recognize fair value losses on our investment; the risk posed by managing an increasingly complex supply chain that has the ability to supply a sufficient quantity of raw materials, subsystems and finished products with the required specifications and quality; the risk we may be required to record a significant charge to earnings if our goodwill or amortizable assets become impaired; risks relating to confidential information theft or misuse, including through cyber-attacks or cyber intrusion; our ability to complete development and commercialization of products under development, such as our pipeline of Wolfspeed products, improved LED chips, LED components, and LED lighting products risks related to our multi-year warranty periods for LED lighting products; risks associated with acquisitions, divestitures, joint ventures or investments generally; the rapid development of new technology and competing products that may impair demand or render our products obsolete; the potential lack of customer acceptance for our products; risks associated with ongoing litigation; and other factors discussed in our filings with the Securities and Exchange Commission (SEC), including our report on Form 10 - K for the fiscal year ended June 25, 2017, and subsequent reports filed with the SEC.

According to the Organization for Economic Co-operation and Development, the combined government debt held by the world's advanced economies is at its highest point since the Second World War.

Her agenda also includes proposals to connect every US household to high - speed internet by 2020, train 50,000 new computer science teachers, increase the research and development budgets of the National Science Foundation, and bolster cybersecurity, Reuters reported Tuesday.

The city's mission to improve economic development by expanding its financial - technology sector has fueled a surge of high - paying, white - collar jobs.

Both are business - oriented by nature; Lindahl juggled five jobs to pay for New York University and Simmons ran a Web development shop in high school.

The pictures showed Li being escorted by Gou around the facilities and the State Council statement saying that Li encouraged Gou to further invest in its high - end research and development as well as in supply chain production in China.

H.B. 929 Status: Failed Relates to promotion of cybersecurity in the Commonwealth, initiates several efforts to promote economic development, research and development, and workforce development of the cybersecurity industry in the Commonwealth, creates two new matching grant funds, adds one administered by the Innovation and Entrepreneurship Investment Authority for private entities that collaborate with one or more public institutions of higher education on research and development related to cybersecurity.

Unconventional gas development (UGD), characterized by advances in engineering, including horizontal drilling and high volume hydraulic fracturing, enables extraction of large amounts of fossil fuel from shale deposits at depths that were previously unapproachable [1].

Expenses for other direct program expenses (excluding other transfer payments) could be $ 2 billion higher than estimated in Budget 2012, especially if the Government decides to book the shortfall in the environmental liability as identified by the Commissioner for the Environment and Sustainable Development.

Synopsis: Offering a complete course of instruction, «Higher Probability Commodity Trading: A Comprehensive Guide to Commodity Market Analysis, Strategy Development, and Risk Management Techniques Aimed at Favorably Shifting the Odds of Success» takes readers explains commodity markets by shedding light on topics rarely discussed in trading literature from a unique perspective, with the intention of increasing the odds of success for market participants.

Neuromation is dedicated to the democratization of AI for researchers, businesses, and individuals by lowering the high costs of the development and training of applied AI systems.

After years of development and flickering just outside of mainstream consciousness and acceptance, record high prices for the most popular blockchain - based cryptocurrencies Bitcoin and newcomer Ethereum and an embrace of the technology's core principles by some of the world's largest institutions may mean that blockchain technology is ready for its close up.

Florida's High Tech Corridor spans 23 counties across the state, connected by three research universities, more than 20 local and regional economic development organizations, 14 community and state colleges, 12 regional workforce boards, countless industry groups and the thousands of innovative companies that call this region home.

Factors that could cause actual results to differ materially from those expressed or implied in any forward - looking statements include, but are not limited to: changes in consumer discretionary spending; our eCommerce platform not producing the anticipated benefits within the expected time - frame or at all; the streamlining of the Company's vendor base and execution of the Company's new merchandising strategy not producing the anticipated benefits within the expected time - frame or at all; the amount that we invest in strategic transactions and the timing and success of those investments; the integration of strategic acquisitions being more difficult, time - consuming, or costly than expected; inventory turn; changes in the competitive market and competition amongst retailers; changes in consumer demand or shopping patterns and our ability to identify new trends and have the right trending products in our stores and on our website; changes in existing tax, labor and other laws and regulations, including those changing tax rates and imposing new taxes and surcharges; limitations on the availability of attractive retail store sites; omni - channel growth; unauthorized disclosure of sensitive or confidential customer information; risks relating to our private brand offerings and new retail concepts; disruptions with our eCommerce platform, including issues caused by high volumes of users or transactions, or our information systems; factors affecting our vendors, including supply chain and currency risks; talent needs and the loss of Edward W. Stack, our Chairman and Chief Executive Officer; developments with sports leagues, professional athletes or sports superstars; weather - related disruptions and seasonality of our business; and risks associated with being a controlled company.

Overall Event Summary Power Series Racing with Jim Burke - sub $ 1000 autonomous vehicle competition Comma.AI with George Hotz - company developing autonomous vehicles Swift Navigation with Dennis Zollo - centimeter accurate GPS PolySync with Josh Hartung - vehicle software platform Renovo with Chris Heiser - high end electric vehicle platform AutonomouStuff with Bobby Hambrick - autonomous development platform Plus a bonus video, The Race to Autonomous Driving, produced by our friends at Velodyne Thanks to Matt Cross at Frame44 for filming, editing, and producing these videos!

As an initiative of the Florida High Tech Corridor Council in partnership with local economic development organizations, the Virtual Entrepreneur Center offers a catalog of local, regional and statewide business resources organized by county, plus profiles of local entrepreneurs to facilitate connections.

Darin Kingston of d.light, whose profitable solar - powered LED lanterns simultaneously address poverty, education, air pollution / toxic fumes / health risks, energy savings, carbon footprint, and more Janine Benyus, biomimicry pioneer who finds models in the natural world for everything from extracting water from fog (as a desert beetle does) to construction materials (spider silk) to designing flood - resistant buildings by studying anthills in India's monsoon climate, and shows what's possible when you invite the planet to join your design thinking team Dean Cycon, whose coffee company has not only exclusively sold organic fairly traded gourmet coffee and cocoa beans since its founding in 1993, but has funded dozens of village - led community development projects in the lands where he sources his beans John Kremer, whose concept of exponential growth through «biological marketing,» just as a single kernel of corn grows into a plant bearing thousands of new kernels, could completely change your business strategy Amory Lovins of the Rocky Mountain Institute, who built a near - net - zero - energy luxury home back in 1983, and has developed a scientific, economically viable plan to get the entire economy off oil, coal, and nuclear and onto renewables — while keeping and even improving our high standard of living

NEXUS» goal is for its members to achieve higher returns with less risk than typical angel investments by utilizing a model combining the business acumen of NEXUS members with Florida's community resources — including the vast university system and regional economic development programs.

This is the next great challenge for Beijing, and when the regulators finally do start to repair overextended balance sheet, with a much higher debt - to - GDP ratio than any other country at China's stage of economic development, according to a presentation Monday night by my very smart former student, Chen Long, I expect annual GDP growth rates will continue dropping steadily, by 1 - 2 percentage points a year through the rest of this decade (and there has been increasing talk in the past month or two that GDP growth rates are already 1 - 2 points below the printed rates).

«Many investors expected a more lengthy FDA review process of the JCAR015 trial (and potentially other CAR - T programs) and feared that a higher - degree regulatory scrutiny could increase the development risk of CAR T cell,» Leerink Research said in a note co-authored by analysts Michael Schmidt, Ph.D., Jonathan Chang, Ph.D., and Varun Kumar, Ph.D. «While it may take several weeks to reopen all clinical sites of the ROCKET trial, we believe the trial shouldn't be delayed by more than ~ 3 months.»

36 86 is powered by Launch Tennessee, a public - private organization that supports high - growth - potential startups from ideation to exit in capital formation, talent development / retention, access to markets and commercialization.

Back in 2014 — when oil prices were still around $ 100 — the Eagle Ford's economic impact was estimated at $ 123 billion in the 21 - county area — an all - time high to - date, according to a June 2017 report by the University of Texas at San Antonio's Institute for Economic Development.

The PRPA has already completed substantial pre-development work at the sites, improving access, in anticipation of private development spurred by a Request for Expressions of Interest (REI) that was issued late last year and, the port authority said, «garnered a high level of response from maritime industry, manufacturing, and energy companies.»

Responsible for guiding the leadership development process by anticipating turnover, promoting opportunities to attract and retain a high performing diverse workplace.

In year ended June 30, 2014, gross domestic product (GDP) grew 6 %, half a percentage point higher than projected last April by the Asian Development Bank's Outlook (ADO) 2014.

JLL Capital Markets represented the seller, a high - net - worth European family advised by Extell Development.

The number of new build apartment developments in Moscow is set to reach nine - year high, say consultants, while overseas property spending by Russians has hit a new low.

The increase was driven by $ 9 million of higher development margin and $ 4 million of higher resort management and other services revenues, net of expenses.

This is an important development that supports our conviction in the new highs generated by the S&P 500.

Micro Focus software configuration management (SCM) solutions (formally Borland solutions) address the unique needs of large, complex organizations, including large scale parallel development, by integrating disparate tools, teams, and assets into a high performing software supply chain.

By our analysis, SNV is a high risk, low reward stock... Given the significant losses SNV will face across its loan portfolio and particularly in its construction and development portfolio.»

The increase was driven by $ 5 million of higher development margin, $ 2 million of higher rental revenues net of expenses, and $ 2 million of higher resort management and other services revenues net of expenses.

Still reeling from two successive hikes to stamp duty in recent years which particularly hit the higher value prime central London (PCL) property market, appetite to transact has also been buffeted by Brexit - inspired political uncertainty, domestic economic jitters and a surplus of luxury new build developments gearing up to enter the market.

Based in Alexandria, VA and founded in 1989, Columbia Capital invests in high - growth businesses by contributing equity capital and sector - specific expertise across all stages of development in the communications, media and technology sectors.

The companies represented by Equedia.com are typically development - stage companies that pose a much higher risk to investors.

According to the research of York University scholar Qiang Zha, the Canadian International Development Agency has invested more than $ 250 million in higher education since the early - 1980s, an amount surpassed only by investments made by the World Bank during the same period.