Sentences with phrase «by high development costs»

Now a $ 60 billion market for the biotechnology and pharmaceutical sectors, growth of the market has been hampered by high development costs of producing these in animal cell systems, which when factoring in a long period for manufacturing, R&D and clinical trials, may reach around $ 1 billion per each therapeutic candidate.

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

Actual results, including with respect to our targets and prospects, could differ materially due to a number of factors, including the risk that we may not obtain sufficient orders to achieve our targeted revenues; price competition in key markets; the risk that we or our channel partners are not able to develop and expand customer bases and accurately anticipate demand from end customers, which can result in increased inventory and reduced orders as we experience wide fluctuations in supply and demand; the risk that our commercial Lighting Products results will continue to suffer if new issues arise regarding issues related to product quality for this business; the risk that we may experience production difficulties that preclude us from shipping sufficient quantities to meet customer orders or that result in higher production costs and lower margins; our ability to lower costs; the risk that our results will suffer if we are unable to balance fluctuations in customer demand and capacity, including bringing on additional capacity on a timely basis to meet customer demand; the risk that longer manufacturing lead times may cause customers to fulfill their orders with a competitor's products instead; the risk that the economic and political uncertainty caused by the proposed tariffs by the United States on Chinese goods, and any corresponding Chinese tariffs in response, may negatively impact demand for our products; product mix; risks associated with the ramp - up of production of our new products, and our entry into new business channels different from those in which we have historically operated; the risk that customers do not maintain their favorable perception of our brand and products, resulting in lower demand for our products; the risk that our products fail to perform or fail to meet customer requirements or expectations, resulting in significant additional costs, including costs associated with warranty returns or the potential recall of our products; ongoing uncertainty in global economic conditions, infrastructure development or customer demand that could negatively affect product demand, collectability of receivables and other related matters as consumers and businesses may defer purchases or payments, or default on payments; risks resulting from the concentration of our business among few customers, including the risk that customers may reduce or cancel orders or fail to honor purchase commitments; the risk that we are not able to enter into acceptable contractual arrangements with the significant customers of the acquired Infineon RF Power business or otherwise not fully realize anticipated benefits of the transaction; the risk that retail customers may alter promotional pricing, increase promotion of a competitor's products over our products or reduce their inventory levels, all of which could negatively affect product demand; the risk that our investments may experience periods of significant stock price volatility causing us to recognize fair value losses on our investment; the risk posed by managing an increasingly complex supply chain that has the ability to supply a sufficient quantity of raw materials, subsystems and finished products with the required specifications and quality; the risk we may be required to record a significant charge to earnings if our goodwill or amortizable assets become impaired; risks relating to confidential information theft or misuse, including through cyber-attacks or cyber intrusion; our ability to complete development and commercialization of products under development, such as our pipeline of Wolfspeed products, improved LED chips, LED components, and LED lighting products risks related to our multi-year warranty periods for LED lighting products; risks associated with acquisitions, divestitures, joint ventures or investments generally; the rapid development of new technology and competing products that may impair demand or render our products obsolete; the potential lack of customer acceptance for our products; risks associated with ongoing litigation; and other factors discussed in our filings with the Securities and Exchange Commission (SEC), including our report on Form 10 - K for the fiscal year ended June 25, 2017, and subsequent reports filed with the SEC.

Neuromation is dedicated to the democratization of AI for researchers, businesses, and individuals by lowering the high costs of the development and training of applied AI systems.

The great issues of our time are moral: the uses of power; wealth and poverty; human rights; the moral quality and character of society; loss of the sense of the common good in tandem with the pampering of private interests; domestic violence; outrageous legal and medical costs in a system of maldistributed services; unprecedented developments in biotechnologies which portend good but risk evil; the violation of public trust by high elected officials and their appointees; the growing militarization of many societies; continued racism; the persistence of hunger and malnutrition; a still exploding population in societies hard put to increase jobs and resources; abortion; euthanasia; care for the environment; the claims of future generations.

This classic theological insight has been obscured or rejected by many current developments in theology, but the costs may be extremely high, for its implications may well be true not only of personal moral and spiritual life, but of the entire biophysical cosmos as well.

A highly segmented internal market and regulatory framework characterised by high product development and licence maintenance costs, limiting availability particularly in smaller markets and for minor species,

And Heidi Burkhart, president of the affordable housing brokerage Dane Real Estate, warned that the higher construction wages negotiated by REBNY and the Building Trades Council could stifle development on projects with high land costs and thin margins.

By so doing, they earn generous clean development mechanism credits with prices set at the high European levels — prices that are not connected to the actual cost of the upgrades for HFC - 23.

This alternative requires software development by the institution — and, usually, a high volume of applications to justify the cost.

By increasing the artemisinin content of each leaf, the development of high ‐ yielding Artemisia crops will slash the cost of extraction.

Moffitt researchers want to develop a fast, cost - effective blood test that can accurately differentiate low - risk IPMNs that can be monitored from high - risk IPMNs that need to be surgically removed by studying microRNAs (miRNAs), a class of small molecules that regulate key genes involved in the development and progression of cancer.

Massive cost overruns on NASA's James Webb Space Telescope will imperil funding for the agency's on - orbit astronomy missions while potentially wiping out big - ticket space observatories and a host of less - expensive development projects deemed high priorities by the science community, according to experts.

By using a modular approach NASA can develop the high - cost development elements first and then build the rockets in higher numbers to achieve savings.

While the short - term eLearning development cost may be high, eLearning can end up saving companies huge chunks of training and development budgets by eliminating major instructor - led training expenses.

From the embarrassment of approving abysmally low — and Plessy v. Ferguson - like — proficiency targets (including that for Virginia, which had only required districts to ensure that 57 percent of black students and 65 percent of Latino peers were proficient in math by 2016 - 2017), to complaints from House Education and the Workforce Committee Ranking Minority Member George Miller and civil rights - based reformers about how the administration allowed states such as South Dakota to count General Education Development certificates in their graduation rate calculations (and minimize graduation rates as a factor in accountability measures), the administration finds itself contending with complaints from civil rights - based reformers as well as from centrist Democrats finally acknowledging the high cost of their push for revamping No Child at any cost.

Investing wisely in teacher and principal preparation and development can improve student achievement and generate overall budget savings by reducing costs associated with low student performance (including grade retention, remediation, and higher dropout rates).

Why Understanding the Costs of Preschool Quality is Important: A Webinar for Preschool Development Grantee States presents and demonstrates the use of the Cost of Preschool Quality Tool (CPQ) by the Center on Enhancing Early Learning Outcomes, an Excel based model that can be used at the state or district level to estimate the cost of expanding high quality preschool for 3 and 4 year oCost of Preschool Quality Tool (CPQ) by the Center on Enhancing Early Learning Outcomes, an Excel based model that can be used at the state or district level to estimate the cost of expanding high quality preschool for 3 and 4 year ocost of expanding high quality preschool for 3 and 4 year olds.

Interactive and engaging eLearning courses are preferable by one and all; but earlier, the development of such courses involved huge costs and higher developmental time.

The Corvette team says it passed on a dual - clutch automatic because it needs the high - torque capacity, and must spread the cost of transmission development by sharing it with the high - volume trucks.

In addition to the activities described above, the FAST Act expanded eligible purposes to include financing economic development, including commercial and residential development, and related infrastructure and activities, that (i) incorporate private investment, (ii) is physically or functionally related to a passenger rail station or multimodal station that includes rail service, (iii) has a high probability of the applicant commencing the contracting process for construction not later than 90 days after the date on which the RRIF loan or loan guarantee is obligated, and (iv) has a high probability of reducing the need for financial assistance under any other Federal program for the relevant passenger rail station or service by increasing ridership, tenant lease payments, or other activities that generate revenue exceeding costs (Transit - Oriented Development Projects or TODdevelopment, including commercial and residential development, and related infrastructure and activities, that (i) incorporate private investment, (ii) is physically or functionally related to a passenger rail station or multimodal station that includes rail service, (iii) has a high probability of the applicant commencing the contracting process for construction not later than 90 days after the date on which the RRIF loan or loan guarantee is obligated, and (iv) has a high probability of reducing the need for financial assistance under any other Federal program for the relevant passenger rail station or service by increasing ridership, tenant lease payments, or other activities that generate revenue exceeding costs (Transit - Oriented Development Projects or TODdevelopment, and related infrastructure and activities, that (i) incorporate private investment, (ii) is physically or functionally related to a passenger rail station or multimodal station that includes rail service, (iii) has a high probability of the applicant commencing the contracting process for construction not later than 90 days after the date on which the RRIF loan or loan guarantee is obligated, and (iv) has a high probability of reducing the need for financial assistance under any other Federal program for the relevant passenger rail station or service by increasing ridership, tenant lease payments, or other activities that generate revenue exceeding costs (Transit - Oriented Development Projects or TODDevelopment Projects or TOD Projects).

The «under performance of the benchmarks» and associated high costs led to the development of index funds, most notably by Vanguard.

Ubisoft itself offsets massive game budget costs by basing its development operations in certain regions of Canada — where tax breaks as high as 37.5 per cent are on offer.

Mr. Damon's commitment to raise $ 1 million through that group and the OneXOne Foundation in the next year was one of a bundle of pledges aimed at water and sanitation from individuals, charities and companies totalling about $ 400 million (including a $ 200 million pledge by Napo Pharmaceuticals to «complete the clinical development of crofelemer, a drug that has potential to treat pediatric diarrhea, and provide it at cost to partner organizations for distribution in the areas with the highest mortality and morbidity associated with diarrheal diseases.»)

d. Changing perceptions of the risks and benefits of nuclear power leads to increasing public support for nuclear > allows the NRC licensing process to be completely revamped and the culture of the organisation to be changed from «safety first» to an appropriate balance of all costs and risks, including the consequences of retarding nuclear development and rollout by making it too expensive to compete as well as it could if the costs were lower (e.g. higher fatalities per TWh if nuclear is not allowed to be cheaper than fossil fuels);

Despite over 50 - years of development and government support in Canada, nuclear power continues to be plagued by cost overruns, technical problems, accidents and the ongoing problem of how to manage its legacy of high - level nuclear waste.

A May 2006 investigative report [PDF] by the Commerce Department Inspector General was sharply critical of high - level federal management for failing to deal effectively with the long delays and major cost overruns in the development and deployment of NPOESS.

«By combining our global presence and expertise in systems integration with Demand Energy's software and established product offering, we will expand the development of renewables and storage both in the US and globally, delivering a clean, reliable, high - tech and cost - effective energy solution,» he said.

In addition, conventional cars are made with established technology where the high discovery costs have already been paid; hybrids, by contrast, are still undergoing serious development and change, so the R&D; costs are high and it's much harder to recycle the pieces of the vehicle when it reaches the end of its life.

Interactions between climate change and global economic growth: relevant stresses are linked not only to impacts of climate change on such things as resource supply and waste management but also to impacts of climate change response policies, which could affect development paths by requiring higher cost fuel choices (high confidence).

The numbers are consistent with a Carbon Tracker report released in May which argued that seven major oil and gas companies could create $ 100 billion (U.S.) in value by avoiding high - cost development.

By providing high - value, cost - effective legal services to organisations involved in research and development projects, asset operation and maintenance, and decommissioning, we enable our clients to focus on driving their activities forward.

Led by Andy Ellis, Practico has been at the forefront of important developments in the costs industry and has been instructed in a wide range of landmark cases, particularly in the high value and group action arenas.

The healthcare industry has become extremely competitive in the delivery of high quality and cost - efficient care to patients, in the recruitment of physicians by clinics and hospitals, and the development of referral sources by physicians, clinics, and hospitals.

Close on the heels of the finance ministry's warning to public sector general insurance companies for huge underwriting losses and their dependence on investment income for profits, a report co-authored by a former Member of the Insurance Regulatory and Development Authority of India (IRDAI) has blamed the regulatory framework and support system which tend to «over-regulate», high cost of compliance and less «development oriented» policies for the segmDevelopment Authority of India (IRDAI) has blamed the regulatory framework and support system which tend to «over-regulate», high cost of compliance and less «development oriented» policies for the segmdevelopment oriented» policies for the segment's woes.

Supply chain sources said that the unit cost for 3D sensors adopted by latest iPhone devices hit a high of US$ 60 as the technology involves substantial efforts in the development of software, hardware and system integration, significantly pushing up smartphone costs.

«At this point, Apple is the only company who is able to roll out micro-LED, a technology that is still at an early stage of development, and cover the high costs incurred by the low yield rate,» said a source that spoke to Nikkei.

yro.slashdot.org - In a shocking development, Uber said on Friday it has settled the high - stakes trade - secret theft lawsuit brought by Alphabet's Waymo, resolving a conflict that already cost the ride - hailing giant its top driverless car engineer and threatened to further embarrass the company.

Areas of Expertise: Oil & Gas - Instrumentation & Control Engineering - Digital & Satellite Communications Shaping the future of product development by bridging the gap between operational needs and technical realities Equating higher - quality, cost - efficient products and services to business growth and global competitiveness Ensuring smooth deployment of new technologies Level - headed leader and big - picture thinker with broa...

• Coordinated effort between Development, QA, Production, DR, System, DBA, Production - support, Network Administration, Applications group and vendors for project completion ahead of schedule under budget • Incorporated new technologies with legacy systems to improve performance and reduce cost • Experienced in incorporating leading open source tools: nagios, mysql, tomcat, apache, wikis, etc. • Performed broad range of UNIX Systems, Net - Working and SAN Administration tasks for large financial and networking clients such as HSBC Bank USA, Deutsche Bank, Citi Group, ISO.com, GE Corporate Treasury, Globeop Financial Services, LLC., Sothebys.com, Church Pension Group, and Verizon Partners Solutions • Provided project leadership for managing technical resources, client / server issues, vendors, senior management reviews and hands - on technical expertise • Designed and deployed iPlanet Web / Directory server Architecture for the purpose of authentication and Widows 2000 active Directory compatibility • Prepared estimates and diagrams for the new secured Development Environment comprised of Cisco routers, local directors, hubs, Sun servers, firewalls for deployment, staging and production • Developed one to one disaster recovery using Bourne Shell scripting for Reuters» Kondor 3.0 on Solaris 8 • Minimized website down time through careful monitoring of Sotheby's Web Vision to Amazon by using FTP servers to manage high volume uploads which optimized online trading functionalities • Directed installation, configuration, and security of multiple online global auction sites • Automated operations, disk space monitoring, and backups using Bourne and Korn Shell scripting • Developed standard operating procedure for IP multi-pathing, Emulex LPFC, HBAs, EMC Power path, Navisphere, and installed JASS on new built servers

Client Services Supervisor — Duties & Responsibilities Responsible for electronic payroll system operations for a large and economically diverse client base Recruit, train, and direct customer service, sales, technical, and administrative staff ensuring efficient operations Maintain working knowledge of proprietary software, industry best practices, employment law, and tax law Oversee adherence to departmental budgets, project timelines, and company policies Coordinate efforts between multiple departments resulting in timely and cost - effective project completion Design and implement professional development programs to enhance team skill sets Utilize employee recognition programs to build morale and dedication to company mission Represent company brand with poise, integrity, and positivity Study internal literature to become an expert on products and services Develop a rapport with customers and orient them to various products and services Encourage high customer retention by maintaining friendly, supportive contact with existing clients Interact with support staff and company resources effectively to create the best consumer experience Utilize technical proficiencies and industry knowledge to offer guidance and support to coworkers and clients Craft effective presentations and proposals, tailoring them to clients based on their specific needs and styles Maintain sales and customer service records detailing pricings, sales, activities reports, and other pertinent data Manage company financial records providing detailed, accurate account of transactions and financial health Build and strengthen long term relationships with peers, clients, partners, and industry leaders Provide additional operational support including communications, data entry, and other tasks as needed Consistently promoted due to excellence in management, customer service, technical support, and sales

Hospitality Sales Manager — Duties & Responsibilities Direct all daily operations, sales, customer service, and finances for multiple hotels, resorts, and other businesses Recruit, train, and direct staff ensuring they understand the brand and adhere to company policies and procedures Design and implement marketing and sales campaigns resulting in increased revenue Consistently exceed sales goals through effective marketing, networking, and other tactics Make cold calls in a courteous, yet assertive manner that translates to sales results Perform research on prospective leads and existing clients to assist in developing sales strategies Craft effective sales presentations and proposals, tailoring them to clients based on their specific needs and styles Develop a rapport with customers and orient them to various products and services Encourage high customer retention by maintaining friendly, supportive contact with existing clients Interact with support staff and company resources effectively to create the best consumer experience Maintain comprehensive records detailing pricings, sales, activities reports, and other pertinent data Study internal literature to become an expert on products and services Set company budgets, maintain profit / loss statements, and ensure overall financial health Cut operational costs through effective inventory management and employee scheduling Negotiate contracts and agreements with suppliers securing quality products at low prices Create employee development programs building staff skill sets and value Utilize employee recognition tactics to build morale and company loyalty Perform administrative duties such as data entry, filing, faxing, and phones as needed Represent company brand with poise, integrity, and positivity

Children who do not complete high school, for example, are more likely to become teenage parents, to be unemployed, and to be incarcerated, all of which exact heavy social and economic costs.5 A growing body of research shows that child poverty is associated with neuroendocrine dysregulation that may alter brain function and may contribute to the development of chronic cardiovascular, immune, and psychiatric disorders.6 The economic cost of child poverty to society can be estimated by anticipating future lost productivity and increased social expenditure.

The importance of early interventions that target caregiving is underscored by studies demonstrating high cost - effectiveness through greatly enhanced long - term outcomes.41 Furthermore, children who receive more nurturing caregiving may also be protected from exposure to stressful life events, suggesting this central target may have positive ramifications on brain development.42 Considering these issues, study findings are relevant to the public policy debate on the importance of early preschool programs for young children living in poverty.

There are few vehicles to provide this training and mentoring, and it inspired us to consider that scholarship help could also be offered for therapists to have greater access to professional development, either by offsetting costs to send them to other places for courses or by raising funds to bring high calibre training to Charleston.

In the mid-1980s, three developments long in the making — a dramatic increase in out - of - wedlock childbearing, the high cost of providing welfare to young poor women who become mothers, and the difficulties faced by their children — became a focus of concern among policymakers and the public alike.

Now NAR's watching another issue that it believes could mean higher costs for consumers: a proposal by the U.S. Department of Housing and Urban Development that would allow settlement service providers to sell consumers a bundled service package for a guaranteed fee.

Higher development fees in many municipalities are also adding to costs, as are fuel surcharges increasingly being levied by gravel, lumber and concrete suppliers in the face of soaring diesel prices.»

Difficult Development Area A difficult development area is any area designated by the U.S. Department of Housing & Urban Development, which has high construction, land or utility costs relative to area median grDevelopment Area A difficult development area is any area designated by the U.S. Department of Housing & Urban Development, which has high construction, land or utility costs relative to area median grdevelopment area is any area designated by the U.S. Department of Housing & Urban Development, which has high construction, land or utility costs relative to area median grDevelopment, which has high construction, land or utility costs relative to area median gross income.

Agency Plus Financing - high cost mortgage loans: You can be approved up to $ 636,150 for one - unit properties in certain high - cost areas (defined by the U.S. Department of Housing and Urban Development HUD).