Sentences with phrase «by human adenovirus»

Not exact matches

There are innumerable different viruses, but the human adenovirus 5, which normally causes the symptoms of a typical cold, has substantial advantages: Its genome can be replaced completely by an artificial one which contains only «useful» genes.

To assess cross-neutralization of TMAdV by known human adenoviruses, 7 pools of in - house reference sera at the VRDL (rabbit hyperimmune sera) and collectively containing antibodies to human adenovirus serotypes 1 through 35 were available for testing.

The significant overall sequence divergence of TMAdV from known human and simian adenoviruses is highlighted by the finding that PAdV - A (porcine adenovirus A), a non - primate mammalian adenovirus, shared only a slightly less similar whole - genome pairwise identity to TMAdV of 47.0 % (Fig. 4).

Clinical samples were also sent to an outside laboratory (Focus Diagnostics, Cypress, CA) for respiratory viral testing by centrifugation - enhanced shell vial culture followed by direct fluorescent antibody staining for 8 viruses (respiratory syncytial virus, adenovirus, influenza virus A and B, parainfluenza virus types 1, 2, and 3, and human metapneumovirus).

Humans are infected by common serotypes of human adenovirus such as AdHu5 and a significant percentage has neutralizing antibodies to this serotypes, which impair the efficacy of AdHu5 based vaccines.

To do this, a team led by Matthew Weitzman of the University of Pennsylvania crosslinked the host factors of infected human cells with the DNA of adenovirus, herpes simplex virus and vaccinia virus.

Increased permissivity of monkey cells to human adenovirus multiplication is affected by culturing conditions and correlates with both synthesis of virion fiber protein and altered splicing of its mRNA

Both transient transfection with Lipofectamine and transduction with adenovirus resulted in a subpopulation of cells that experessed human IgG, as shown by the increased fluorescence intensity.

Improving the oncolytic potency of agents has been hampered by the inability to study host - vector interactions in immune - competent systems, since human serotype adenoviruses do not productively replicate in animal tissues.