This is in agreement with the situation in vivo, where defects in GS activity are compensated for
by hyperinsulinemia and hyperglycemia until glycogen synthesis becomes «normal.»
Not exact matches
Testosterone deficiency aggravates the MetS in men
by bringing forward obesity and
hyperinsulinemia, which in turn suppresses testicular androgen production («vicious cycle»)(also discussed in II.G).
Furthermore, these variables could be secondarily modified
by chronic
hyperinsulinemia.
In this condition, vascular cells could become dysfunctional because of
hyperinsulinemia or because vascular cells themselves are insulin resistant, which is caused
by increased insulin production from pancreatic beta cells as a compensatory mechanism to overcome insulin resistance.
But obesity is
by definition a disease caused
by too much insulin —
hyperinsulinemia.
Yes, having
hyperinsulinemia — too high levels of insulin in the blood — like type 2 diabetics have, is not a good thing, and may increase cancer
by like 10 %.
A classical ketogenic diet — with a staggering 70 - 90 percent of total calories coming from fat — might not be necessary.51 Classical ketogenic diets restrict protein as well as carbohydrate, since 48 - 58 percent of the amino acids in dietary proteins can be glucogenic, thereby undermining the purpose of a diet intended to generate a high amount of ketones and limit glucose as much as possible.46 As therapy for AD, however, simply lowering carbohydrate intake to a point where some ketones are generated and
hyperinsulinemia is corrected could have positive effects just
by easing the metabolic burden on the brain.
A complete review of all available studies estimates that
hyperinsulinemia increases the risk of hypertension
by 63 %.
The patient dies a self induced death caused
by complications from
hyperinsulinemia.
Insulin resistance is reduced with an LCKD, possibly
by a reduction in the availability of dietary glucose, which causes
hyperinsulinemia (44, 45).
However, this backfires, as the
hyperinsulinemia, made worse
by the attendant glucose load, leads to further insulin resistance.
Insulin resistance,
hyperinsulinemia and high blood glucose (caused
by being overweight, eating too much sugar and refined carbs, not exercising, stress and not enough sleep) are associated with an increased risk of breast cancer.
A high intake of dietary fiber, particularly of the soluble type, above the level recommended
by the ADA, improves glycemic control, decreases
hyperinsulinemia, and lowers plasma lipid concentrations in patients with type 2 diabetes.
In conclusion, an increase in the intake of dietary fiber, predominantly of the soluble type,
by patients with type 2 diabetes mellitus improved glycemic control and decreased
hyperinsulinemia in addition to the expected lowering of plasma lipid concentrations.
In other words, does lower testosterone affect obesity directly or indirectly
by contributing to
hyperinsulinemia?
Specifically, chronic hyperglycemia and
hyperinsulinemia induced
by high glycemic load carbohydrates may elicit a number of hormonal and physiologic changes that promote insulin resistance (71,77,78).
The study reported that obesity caused insulin resistance that resulted in
hyperinsulinemia and glucose intolerance, but these findings were confounded
by the insulin resistance associated with elevated progesterone and growth hormone concentrations that occurs in intact bitches.