Sentences with phrase «by identifying neurons»

Lee and Bonin began by identifying neurons in the mouse visual cortex that responded to particular visual stimuli, such as vertical or horizontal bars on a screen.

Not exact matches

Next, Anderson and his colleagues used a set of genetic tools to identify exactly which neurons were responsible for the effect on aggression and to see if the gene that encodes for Tk also controls aggressive behavior by acting in that cell.

The company had identified a molecule, CGP3466B, that in laboratory tests protected neurons from degeneration by inhibiting apoptosis, and had tested it in clinical trials on patients with Parkinson's disease and amyotrophic lateral sclerosis, or ALS.

Researchers have identified the neurons in monkeys that are dampened by scratching, a finding that could lead to new ways of alleviating itching in humans.

The ~ 200 GB of data for each brain was then analyzed with machine learning algorithms that identify individual neurons by type, according to parameters «learned» from human experts.

The team identifies where neurons are firing by injecting the brain with dyes or using genetically engineered proteins that bind to calcium molecules.

The researchers also identified the specific neuron responsible for detecting high pH. They did this by showing that when a specific sensing neuron, called the ASH neuron, was destroyed by laser microsurgery, the worms no longer avoided high pH. Going another step further, the researchers also identified some of the proteins involved in the response to high alkalinity, which make up a calcium channel.

By tweaking different fly genes and counting how many neuron types were produced as the flies matured, the team identified a network of five genes that work together like coordinated control switches to guide the precursor cells» transformation to mature neurons.

They also applied it to human brain tissue collected by the Genotype - Tissue Expression (GTEx) Project, finding that they could a) identify expression signatures unique to neurons, glial cells, and other cell types in the brain (including rare types), and b) differentiate between closely related cell subtypes.

Described in the January 7th issue of Neuron, the technique uses «deep,» highly sensitive whole - genome sequencing of single neurons and a new technology that identifies inserted bits of DNA caused by retrotransposons, one of several kinds of so - called somatic mutations that can arise as the brain develops.

A Cell study published by Goulding's group earlier this year identified another player in the light - touch circuit: RORα neurons.

By obtaining simultaneous intracellular recordings from both the sensory neurons and one of the main identified motor neurons, we have been able to reduce the reflex to its monosynaptic components.

Belgian researchers have identified a new strategy for treating an inherited form of dementia after attempting to turn stem cells derived from patients into the neurons most affected by the disease.

Egg - laying behavior in Aplysia is mediated by a set of peptides, including egg - laying hormone (ELH), which are released by a cluster of identified neurons, the bag cells.

Now that the biologists had identified one site — out of many — housing neurons that activated selectively for social encounters, they listened in on the goings - on by placing very fine electrodes in proximity.

Blue corresponds to cell nuclei, and green to fluorescence emitted by a green - fluorescent protein that identifies neurons having received the virus that can genetically abolish the expression of lipoprotein lipase protein.

The findings, made in mice, explain why most but not all motor neurons are affected by the disease and identify a potential therapeutic target for this still - incurable neurodegenerative disease.

A specific kind of neuron found only in male mice and that detects a pheromone in female urine has been identified by researchers at Washington University School of Medicine in St. Louis.

«We hope that in the future, by fully understanding how this gene affects signaling in the brain, we may be able to identify drugs to restore the normal signaling balance in neurons and improve cognitive and social function in patients,» says lead author Dr. M. Chiara Manzini.

Molecular profiling of PI cells identified the fly version of DH44 as a circadian molecule that is specifically expressed by PI neurons and required for normal rest / activity rhythms in flies.

Scientists at the Stowers Institute for Medical Research have identified a possible biochemical mechanism by which the specialized brain cells known as neurons create and maintain a long - term memory from a fleeting experience.

A team led by scientists at St. Jude Children's Research Hospital and Mayo Clinic has identified a basic biological mechanism that kills neurons in amyotrophic lateral sclerosis (ALS) and in a related genetic disorder, frontotemporal dementia (FTD), found in some ALS patients.

A new paper published by OIST's Neurobiology Research Unit identifies some of the neurons responsible for behavioral decisions in rats.

By implanting electrodes into the somatosensory cortex — the brain region that registers touch — Brecht and his team have identified the neurons that activate physical responses to tickling (Science, doi.org/bsxv).

So far, Koyuncu and her colleagues have identified two ways for herpes viruses that are destined to be silenced to escape from silencing: a stress - mediated slow route that is initiated by the neuron, and a fast route that is activated by viral tegument proteins.

Emory researchers led by neurologist Manuel Yepes, MD have identified a protein released by neurons while the brain is recovering from a stroke. The results were published online today in Journal of Neuroscience.

A team led by Anandasarkar Ray at the University of California, Riverside, identified an important class of neurons in mosquitoes that detect our skin odors.

Mirror Movement - Like Defects in Startle Behavior of Zebrafish dcc Mutants Are Caused by Aberrant Midline Guidance of Identified Descending Hindbrain Neurons.

An intriguing clue to this selectivity is provided by Setola et al., who identify a truncated form of SMN1 that arises from an alternative spliced SMN1 transcript that is preferentially expressed in the axonal projections of developing motor neurons.

Almost all of these small neurons were identified to be cerebellar granule cells based on their morphology and that they were stained by anti-neural cell adhesion molecule L1 (Fig. 1A)[19].

Despite the complexity of our brains, a simple linear calculation by our neurons can immediately identify a smell, they say.

The researchers have shown that a robotic arm guided by a cell - detecting computer algorithm can identify and record from neurons in the living mouse brain with better accuracy and speed than a human experimenter.

By studying the expression of these genes, the neurons that mediate learning have been identified.

The researchers also show in their study (online Sep. 12, 2013, in Neuron) that they could restore proper neuronal growth by compensating for the errant molecular mechanisms they identified.

This is the second continuation of the collaboration to fund a series of research projects initiated in 2006 to identify and optimize compounds with the potential to treat SMA by increasing production of the survival motor neuron (SMN) protein.

We used a bioninformatics analysis to identify that miR - 181a targets components of the bone morphogenetic protein (BMP) signalling pathway, including the transcription factors Smad1 and Smad5, which we find are expressed by rat mDA neurons and are required for BMP - induced neurite growth.

Triple - labelled preparations in which mDA neurons were identified by TH staining revealed that BMPR2 was expressed on, but not limited to, mDA neurons in cultures of the E14 rat VM (Figure 1A, B).

Gene Set Enrichment Analysis (GSEA) was conducted to identify pathways, biological process and molecular functions that are enriched in genes differentially expressed by NSCs or dopaminergic neurons treated with amiodarone HC.

By identifying how sensory motor neurons are connected, Jessell has opened the door to potential strategies to treat and cure neurodegenerative diseases that impair movement, such as Amyotrophic Lateral Sclerosis (Lou Gehrig's disease).

The research conducted by Wright State University involved identifying and measuring size changes of motor neuron types in a mouse model of familial ALS.