11/6/2007 UCSD Researchers Discover Inflammation, Not Obesity, Cause of Insulin Resistance Findings may have important potential for new drug discoveries in fight against Type 2 diabetes Researchers at the University of California, San Diego (UCSD) School of Medicine have discovered that inflammation provoked
by immune cells called macrop... More...
In the brain, a synapse (orange) is seen being wrapped around and attacked
by immune cells called microglia (green), leading to synapse loss.
Further experiments suggested that the production of high levels of cell wall - associated GAG makes A. fumigatus more resistant than A. nidulans to neutrophil killing by neutrophil extracellular traps, or NETs (NETs are are networks of extracellular fibers, composed of DNA and proteins secreted
by immune cells called neutrophils, that bind and trap various pathogens).
Ferumoxytol leaks out of blood vessels in areas of inflammation and is taken up
by immune cells called macrophages, which congregate at sites of inflammation.
An antibody is Y shaped protein that is produced
by an immune cell called a plasma cell in response to invasion by a a microbe (virus or bacteria).
Not exact matches
The tattooing process works
by injecting ink into the skin, which stimulates an
immune response in which
cells called «macrophages» move into the area and «eat up» the ink.
«These attacks have grown in magnitude and they include attacks on security services, we have incidents where military officers have been lynched
by mobs, we have instances where these vigilante groups
calling themselves variously; Invisible forces, Delta forces, etc. invade police stations, break into
cells and release suspects because they claim the NPP members are
immune to any form of arrest in other words, they are living above the law because they happen to be members of a party living in power», he said.
Baby Layla's medical team treated her with
immune cells altered
by one type of the molecular surgical instruments
called TALENs.
But during pregnancy, the fetus is protected from the mother's
immune system
by the placenta, which has specialized
cells —
called trophoblasts — that can burrow into the mother's body without exciting an attack
by the
immune system.
«We found that a protein expressed
by gut bacteria
called Bacteroides works to prevent IBD
by rapidly recruiting white blood
cells to kill a
cell of the
immune system that is responsible for orchestrating IBD,» says McCoy.
The so -
called STEP trial, sponsored
by pharmaceutical giant Merck & Co. and the federally funded HIV Vaccine Trials Network (HVTN), was the first to test the idea of stimulating the
immune system's killer T
cells to hunt for the virus more aggressively, in this case using a weakened form of the cold virus to carry three genes from HIV.
«A personalised immunotherapy was prepared for each patient
by taking a sample of their blood and extracting a particular type of
immune cell called dendritic
cells.
The enzyme is produced
by white blood
cells called neutrophils, which play an important role in inflammatory and
immune responses and may be a key contributor to the development of muscular dystrophy.
An animal's
immune system detects foreign
cells by scanning for proteins,
called antigens, that stick out from the surface of each
cell.
The invasion of epithelial
cells and
immune cells are controlled
by two separate gene clusters
called Salmonella Pathogenicity Islands 1 and 2 (SPI1, SPI2) respectively.
The third approach turns up production of T regulatory
cells, which prevent specific
immune cells from copying themselves and can also suppress rejection
by secreting biochemicals
called cytokines that direct the
immune orchestra to change its tune.
These chemicals,
called cytokines, drive the inflammation in the brain, attracting more
immune cells, and causing the debilitating disease marked
by loss of neurological function.
By manipulating the function of certain
immune cells,
called T
cells, researchers could help restore the system's balance and create new treatments to target these diseases.
Since a primary function of the dendritic
cells is to present an antigen to T -
cells, to activate the T -
cells and begin the
immune response, the researchers suspected that T -
cell activation in the heart tissue, and perhaps heart - tissue injury caused
by T -
cells, might be central to the pathological heart enlargement that is
called remodeling.
Research published on August 7th in PLOS Pathogens comparing the two pathogens reveals how S. Typhi avoids recognition and elimination
by patrolling
immune cells called neutrophils, allowing it to disseminate throughout the patient's body.
An additional mechanism to prevent the
immune response from going «overboard,» the researchers conclude, is provided
by a subset of T -
cells called induced regulatory T -
cells (iTreg
cells).
The
immune system recognizes transplanted organs as foreign tissue
by telltale proteins,
called the major histocompatibility complex (MHC), that coat
cell surfaces.
Cells in the innate
immune system respond immediately
by secreting inflammatory factors
called cytokines to stop the spread of infection.
A new optogenetic technology developed
by scientists at the University of Massachusetts Medical School and Texas A&M Health Science Center Institute of Biosciences & Technology,
called optogenetic immunomodulation, is capable of turning on
immune cells to attack melanoma tumors in mice.
In many cases the damage is caused
by a particular group of
immune cells called effector memory T -
cells.
Researchers looking at the white blood
cells called eosinophils found a new weapon in the
immune arsenal: toxic webs of DNA flung in less than a second
by a kind of cellular catapult.
Daniel Getts, chief scientific officer of Cour Pharma in Chicago, Illinois, says he has written WHO to suggest the use of his company's
Immune Modifying Nanoparticles, designed to reduce tissue damage
by binding
immune cells called monocytes.
Previous studies in the lab showed that once HCMV is inside the
cell, it quickly becomes latent
by entering the
cell's nucleus and co-opting a cellular protein
called Daxx — part of the intrinsic
immune system — to shut down its own replication, the process of reproducing its genetic material to make more copies of itself.
Moffitt researchers wanted to determine if it would be possible to activate the cancer - fighting properties of T
cells indirectly
by targeting another type of
immune cell called a dendritic
cell.
These molecules function
by shuttling broken - down proteins
called peptides from inside the
cell to the surface, where other
immune cells inspect them to see whether they are invaders.
However, this re-activation is blocked in most latently - infected
cells by cellular molecules
called immune check - points.
In the present work, the teams led
by Michael Ewers (ISD) and EMBO Member Christian Haass (DZNE) focussed on the TREM2 protein, which functions in specialized brain
immune cells called microglia that clear toxic material resulting from nerve
cell injury.
Normally,
immune cells called neutrophils kill microbes
by gobbling them up or releasing toxic chemicals.
Researchers led
by Van Allen and Choueiri sought an explanation for why some patients with a form of metastatic kidney cancer
called clear
cell renal
cell cancer (ccRCC) gain clinical benefit — sometimes durable — from treatment with
immune checkpoint inhibitors that block the PD - 1 checkpoint, while other patients don't.
Estes, who works with virologist Jeffrey Lifson, has also developed a DNAscope to visualize this HIV DNA —
called the provirus — which becomes integrated into human
cells and can persist for decades without being attacked
by the
immune system or antiretroviral (ARV) drugs.
Once donor blood
cells mix with recipient
immune cells, they blunt the
immune attack
by a process
called negative selection, says Strober, who has spent 30 years developing the regimen.
Tumor
cells develop mechanisms to evade detection
by the
immune system
by expressing a protein
called PD - L1.
The sequence,
called an ITAM (immunoreceptor tyrosine - based activation motif), encodes a piece of protein that can
by itself signal
immune system
cells to multiply and go to work.
Johannes Scheid, a student in Nussenzweig's lab, isolated it several years ago from an HIV - infected patient whose
immune system had an exceptional ability to neutralize HIV in the blood
by preventing the virus from infecting and destroying a specific type of
immune cells,
called CD4
cells, in patients.
A study led
by UCLA's Drs. Robert Prins and Linda Liau, both UCLA Jonsson Comprehensive Cancer Center members, looked at the impact of a combined treatment using a chemotherapy drug
called decitabine and genetically modified
immune cells or T
cell immunotherapy.
Shortly after infection, HIV levels skyrocket, but then the
immune system and other antiviral factors produced
by cells drive down the amount of virus in the blood — the so -
called viral load — and establish a «set point.»
HIV wreaks havoc
by destroying
immune cells called T -
cells.
Researchers at St. Jude Children's Research Hospital have discovered the mechanism
by which
immune cells called regulatory T
cells keep themselves intact and functional during their demanding task of holding the
immune system in check.
TREM2 is segregated
by certain
immune cells of the brain —
called microglia — and thus reflects their activity.
he body responds to tuberculosis infection
by locking the bacterial offenders into tiny clusters of
immune cells called granulomas, which are a hallmark of the disease.
When a new bacterium or virus invades the body, the
immune system mounts an attack
by sending in white blood
cells called T -
cells that are tailored to the molecular structure of that invader.
One way they do this is
by transporting the virus to the body's
immune cells, without themselves becoming infected, through a process
called trans - infection.
Older studies have shown that certain compounds can activate iNKT
cells in mice
by stimulating the response of another type of
immune cell called cytokines.
In previous research, a team led
by the same Artyomov showed that inflammatory
immune cells called macrophages produce significant amounts of itaconate when they detect bacteria.
FcRn bears an intriguing structural resemblance to molecules
called major histocompatibility complex (MHC) proteins, which function in the vertebrate adaptive
immune response
by presenting antigenic peptides to T
cells.