Detection of immune cell checkpoint and functional markers in the lung TME: The field of cancer immunotherapy continues to expand rapidly over recent years, with promising clinical results
by immune checkpoint inhibitors and other therapeutic approaches.
The cancer cells» defense strategy can be overcome
by immune checkpoint inhibitor agents, including anti-PD-1 / PD - L1 antibodies, several kinds of which have received fast - track approval from the U.S. Food and Drug Administration (FDA).
Not exact matches
The class of medications that he conceived, known as
immune checkpoint inhibitors, works counterintuitively:
By turning off one of the
immune system's built - in safeguards, the
inhibitors allow T cells — the system's foot soldiers — to attack tumors more effectively.
Known as a
checkpoint inhibitor, tremelimumab is an investigational monoclonal antibody that «cuts the brakes» of the
immune system
by targeting cytotoxic T - lymphocyte antigen 4 (CTLA - 4), a protein that can switch off a patient's
immune response.
Once again, researchers at Penn's Abramson Cancer Center have extended the reach of the
immune system in the fight against metastatic melanoma, this time
by combining the
checkpoint inhibitor tremelimumab with an anti-CD40 monoclonal antibody drug.
Researchers led
by Van Allen and Choueiri sought an explanation for why some patients with a form of metastatic kidney cancer called clear cell renal cell cancer (ccRCC) gain clinical benefit — sometimes durable — from treatment with
immune checkpoint inhibitors that block the PD - 1
checkpoint, while other patients don't.
The drugs, ipilimumab (Yervoy ®) and nivolumab (Opdivo ®), made
by Bristol - Myers Squibb (BMS), are two
immune checkpoint inhibitors that «release the brakes» on the
immune system, allowing it to mount a stronger and more effective attack against cancer.
The data presented provide new insights on the potential mechanism
by which Seres» microbiome therapies could improve the outcomes of cancer patients treated with
immune checkpoint inhibitors.
T - cells (red, yellow, and blue) attack a tumour in a mouse model of breast cancer following treatment with radiation and a PD - L1
immune checkpoint inhibitor, as seen
by transparent tumour tomography.
The first generation of immunotherapies, including
immune checkpoint inhibitors and cancer vaccines, have been limited
by the proportion of patients who benefit, and
by the depth and duration of response in those that do.
In an effort to further exploit the potential of Pexa - Vec to activate the
immune system to fight cancer, as seen in McDonald's preclinical data, SillaJen recently announced a new clinical trial in collaboration with New York - based Regeneron Inc. to test Pexa - Vec and REGN2810, a PD - 1
checkpoint inhibitor, in combination against renal cell carcinoma, and recently signed a sponsored research agreement with UCSF to enable joint support of parallel preclinical experiments
by McDonald's team.
By blocking these inhibitory molecules or, alternatively, activating stimulatory molecules,
checkpoint inhibitors are designed to unleash or enhance pre-existing anti-cancer
immune responses.
Led
by Leena Gandhi, MD, PhD, associate professor of medicine and director of thoracic medical oncology, researchers from the KEYNOTE - 021 study demonstrated for the first time that combining an
immune checkpoint inhibitor — in this case, pembrolizumab — with a platinum - doublet chemotherapy regimen might be more effective than chemotherapy alone as first - line treatment for advanced, non-squamous NSCLC.
The combination of the attenuated oncolytic virus talimogene laherparepvec (T - VEC) and the
immune checkpoint inhibitor pembrolizumab shows activity and is well tolerated
by advanced melanoma patients, according to a new study presented at the Society for Melanoma Research 2015 International Congress, held November 18 — 21 in San Francisco.