Sentences with phrase «by inflammation include»

Health conditions affected by inflammation include: heart disease, cancer, asthma, mood disorders, irritable bowel disorders and rheumatoid arthritis.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Pitta's who are governed by the elements of fire and water will benefit from the cooling qualities of coconut cream that will help to pacify a tendency towards heat imbalance driven problems including fever, inflammation and skin troubles like eczema.

The researchers added: «Other bioactive compounds present in nuts, including micronutrients, fibre, and phytochemicals, may also contribute to their cardio - protective effect by reducing inflammation, improving vascular reactivity as well as fasting glucose and insulin sensitivity, and by lowering oxidative stress status.

Since mastitis is an infection caused by inflammation of the breast, you will have symptoms of inflammation including:

The amber beads on the necklaces include an oil called Succinic Acid, which has been used for pain relief, inflammation, and immune system boosting for centuries by the Europeans.

Clusters of genes that became less active were those governed by a master gene called NF - kappaB, which triggers chronic inflammation leading to diseases including high blood pressure, heart disease, inflammatory bowel disease and some cancers.

Treatment implications might include the potential utility of medications to alter the body's immune response by blocking inflammation, or providing drugs that enhance basal ganglia function, he says.

Specifically, the study authors were able re-create lupus disease processes, including the formation of antibodies to DNA and kidney inflammation, by engineering mice that lacked the gene for DNASE1L3.

These mechanisms may include altered systemic inflammation as a consequence of depression, or even the role of lifestyle behaviors such as physical activity or nutrition, which are typically worsened by depression, and which may place an individual at risk for psoriatic arthritis.

In mice, this form of lipodystrophy was also characterized by «whitening» of brown fat cells, a loss of white fat, and signs of metabolic syndrome, including insulin resistance, fat tissue inflammation, dyslipidemia (elevated cholesterol and fat), increased resting energy use, and increased markers of cardiovascular disease.

Inflammatory arthritis includes a number of autoimmune diseases of the joints — including rheumatoid arthritis and lupus — and in many cases is caused by a type of inflammation called type III hypersensitivity.

Lupus is an autoimmune disorder characterized by periodic inflammation of joints, connective tissues and organs including heart, lungs, kidneys and brain.

Although the reasons why colonoscopy increases the risk of appendicitis remain unclear, the article offers some theories, including asking if bacteria within the colon are altered as the bowel is prepared prior to colonoscopy in ways that increase the likelihood of inflammation, or if the increased air pressure caused by colonoscopy may have effects on the colonic mucosa that can predispose people to appendicitis.

While the biological mechanism by which exposure to pollution causes lower birth weights are not fully understood, the scientists speculate that several factors could play a role, including maternal inflammation, altered placental function, and reduced nutrient delivery to the fetus, which may impede fetal growth.

There are several possible mechanisms by which physical activity can protect against nocturia, including reducing body size, improving sleep, decreasing sympathetic nervous system activity and lowering levels of systemic inflammation.

Less than a decade ago, anti-NMDA receptor encephalitis was first identified, a disease characterized by inflammation of the brain that causes acute psychiatric symptoms including psychosis.

SLE is a genetically complex chronic relapsing autoimmune disease characterised by inflammation that may affect different tissues, including the skin, joint linings, lungs, kidneys and other organs.

It is characterized by an inflammation of the brain, which can result in neurological and psychiatric symptoms, including psychoses, epileptic seizures and movement disorders.

Retroviruses, including HIV, are known to be awakened by inflammation — possibly the result of infection, cigarette smoke, or pollutants in drinking water.

Dr Luca Peruzzotti - Jametti, the first author of the study and a Wellcome Trust Research Training Fellow, says: «We made this discovery by bringing together researchers from diverse fields including regenerative medicine, cancer, mitochondrial biology, inflammation and stroke and cellular reprogramming.

These include lipid lowering; protection from oxidative stress and inflammation; modification of growth factors that can promote cancer; inhibition of nutrient sensing pathways by amino acid restriction and gut microbiota - mediated production of metabolites.

These include genome instability / mutation, which they discussed previously, and tumor - promoting inflammation, mediated by immune system cells that are recruited to the site of a developing tumor.

The World Health Organization defines bronchial asthma as a chronic airway inflammation that is caused by various inflammatory cells, including eosinophils (EOS), mast cells and T lymphocytes (1 — 3).

Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and indomethacin work by inhibiting an enzyme that produces prostaglandins — hormone - like messenger molecules that trigger many processes in the body, including inflammation.

This discovery leads to a major revision of previous paradigm by broadening focus of anti-aging drug discovery and development to include a new likely cellular source of age - associated chronic systemic sterile inflammation.

While much has been made about Mr. Ali's boxing career and its connection to his development of Parkinson's, there are many factors that could have played a role in his illness, including genetics, concussions, and inflammation of the brain caused by repeated blows to the head.

These syndromes include conditions in which autoimmunity is clearly implicated as causal, in light of identification of autoantibodies to relevant autoantigens; diseases suspected to be autoimmune because of the presence of autoantibodies, although the autoreactive response has not been proven to be pathogenic and could be a consequence or marker of tissue damage; and other diseases often considered to be «autoimmune,» such as psoriasis or inflammatory bowel disease, characterized by organ - targeted inflammation but without evidence of a stimulating autoantigen.

Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters

Metabolic Syndrome, which includes obesity and diabetes, represents a major public health concern, caused by a combination of increased food consumption and reduced physical activities, with contributions from host genetics, environment and tissue inflammation.

New research suggests a link between bacteria in your gut, influenced by what you eat, and brain inflammation, including in neurodegenerative diseases like multiple sclerosis.

Too much estrogen in the body (which can be caused by all sorts of reasons including hormonal imbalances, over exposure to phytoestrogens like those found in soy, and xenoestrogens found in plastics) can cause inflammation, infertility and promote accelerated aging.

The same antioxidants that make green tea protective, including epigallocatechin gallate (EGCG), may also help support skin health by reducing inflammation and free radicals that accelerate skin aging.

Inflammation may be a major driver of chronic disease, including mental illness, and is promoted by sugar, stress, and environmental toxins.

By extension, when we keep blood sugar levels even, we reduce inflammation and glycosylation of cells — including the cells of the skin.

Inflammation can be measured by testing several blood markers, including C - reactive protein (CRP), tumor necrosis factor (TNF) and interleukin - 6 (IL - 6).

You can control inflammation by supplementing with anti-inflammatory herbs, including horse chestnut and turmeric.

It is believed by many scientists and researchers that inflammation may be the root cause of most chronic diseases including pain, arthritis, Alzheimer's, Crohn's disease, heart disease, and even cancer.

Fast - forwarding 2400 years, we are still prescribing a plethora of medications for inflammation, including aspirin, while we can likely avoid it in the first place by eating a caveman diet and mimicking a modern caveman lifestyle.

Sugar cravings can be caused by blood sugar imbalances, which occur due to poor diet (including inflammation - inducing high doses of sugar) or going too long between meals.

Enzymes to reduce pain and inflammation Case example of pulling off an autoimmune attack and severe inflammation reduction; including improved circulation The use of cayenne pepper Addressing the issue of Ascites Scarring of the liver Edema and inflammation; additional type of enzyme supplementation Ascites additional options Nausea relief Ascites, edema of the legs and ankles; releasing buildup of fluids DMSO continues to amaze me DMSO Gel form and its external application for pain, swelling, trauma, inflammation and a great deal more Sounds like DMSO is your best friend Working with the DMSO Gel, medications and general warnings Common sense examples when using DMSO Brain inflammation and DMSO The use of niacin (vitamin B3) for Ascites Coffee enemas for major pain relief Pain relief and the application of Castor oil packs in drawing out toxins Castrol oil packs and liver cancer cases Flax oil for pain control Pain control using Bentonite Clay mud packs in drawing out toxins for internal and external use BRAT has been used by many to stop or control Diarrhea issues Charlotte Gerson's book «Healing the Gerson Way» Bentonite clay application for external use including bath Case example of using the Pain Triad

In the present study, we extended prior observations by assessing the correlation of magnesium intake with 3 biomarkers of systemic inflammation, including concentrations of CRP, IL - 6, and sTNF - R2.

Metabolic syndrome is marked by a cluster of health problems (including excess belly fat, high blood pressure, high cholesterol, insulin resistance and inflammation) which are known to raise your risk for heart disease and type - 2 diabetes.

I was curious what your thoughts are on crynotherapy and the benefits a lot of people seem to swear by including muscle recovery and decreased inflammation?

The interesting thing that not many people are made aware of by their doctors is that the inflammation that is induced by the chronic stress is actually what creates the environment for these problems to develop, including the psychological issues mentioned above.

Recent evidence suggests that prebiotics, including fructans and GOSs, modulate brain function by modifying the gut microbiota, decreasing low - grade inflammation, and / or influencing the production of neurochemicals (5, 6).

Excessive inflammation can be escalated by other lifestyle factors in addition to diet, including lack of adequate sleep, stress, alcohol intake, a toxic living environment, substance abuse and medication.

By following these rules, you will reduce the underlying inflammation generating metabolic imbalance we now know are the underlying reasons for most chronic medical problems including diabetes, depression, cancer, food allergies, chronic pain, and more.

The premium product offerings fueled by CarnoSyn ® include Evertrain Pre, designed to optimize training by delivering sustained energy, superior focus, and increased endurance, and Evertrain Post, formulated to reduce recovery time between training sessions by enhancing muscle repair and decreasing inflammation.

Signs that there is a vitamin deficiency may include gingivitis, which is characterized by an inflammation and bleeding gums; dry skin; dry and splitting hair; easy bruising; a decreased ability to ward off infection, nosebleeds; and decreased rate of healing for wounds.