Sentences with phrase «by inflammatory cells»

In affected dogs, the intestine is taken over by inflammatory cells, eventually leading to scar tissue throughout the lining of the digestive system.

The underlying pathology involves infiltration of the bowel wall by inflammatory cells due to altered immune system function.

Whatever the causes, the end result is that the lining of the intestine is invaded by inflammatory cells.

The cause of IBD isn't clearly understood but the end result is the lining of the intestine is invaded by inflammatory cells.

IBD is a physical disease where the intestinal lining is infiltrated by inflammatory cells.

Because FHV - 1 can induce tissue injury directly as a result of viral cytolysis or indirectly through immunopathologic processes mediated by inflammatory cells, treatment of FHV - 1 keratoconjunctivitis involves: 1) prevention of viral replication; 2) immunomodulation; and, 3) prevention of secondary bacterial infection.

We are also investigating targeting the normal source of HB - EGF, inflammatory cells, to determine whether HB - EGF alone or in concert with other cytokines produced by inflammatory cells is necessary for tumor formation.

Despite the increased production of proinflammatory molecules, infiltration of adipose tissue by inflammatory cells has not been described as a common feature of obesity.

The research suggests that a cytokine produced by inflammatory cells near a prostate tumor induces cancer cells to decrease production of a protein that blocks metastasis.

«Everyone thought that if it is produced by inflammatory cells it should fight infection, but no — it's anti-inflammatory.

Not exact matches

The release of inflammatory chemicals called «cytokines» (proteins secreted by specific cells involved in immunity and in inflammation) leads to biochemical reactions involving neurotransmitters.

The high - level of antioxidants and other phytochemicals found in nuts and seeds help prevent chronic and inflammatory diseases by protecting the body against cell oxidation.

«Our study results are the first to argue that we may be able to treat inflammatory bowel disease and protect against transplant rejection not only by blocking TNF alpha as is done currently, but also by stimulating ATG16L1 to prevent early death of cells lining the gut,» says study senior investigator Ken Cadwell, PhD, an associate professor at NYU School of Medicine and NYU Langone Health's Skirball Institute for Biomolecular Medicine.

«Furthermore, we found that these cells are affected by the inflammatory environment and develop inflammatory properties.

By triggering the production of immune cells that curb the inflammatory reaction typical of allergies, M. vaccae may ease that inflammation and hence depression.

What they discovered was that an inflammatory factor known as TGF - beta (transforming growth factor - beta) can give cancer cells properties of immune cells by supplying the surface of the cancer cell with a receptor that normally only exists on the white blood cells that travel through the lymphatic system.

Published in the journal Frontiers in Neuroscience, the researchers have assembled strong evidence that the neurological decline common to these diseases is caused by «auto - inflammation», where the body's own immune system develops a persistent inflammatory response and causes brain cells to die.

Other inflammatory molecules that provoke the microglia are made by the white blood cells that gobble up bacteria and other sources of infection in the body.

The enzyme is produced by white blood cells called neutrophils, which play an important role in inflammatory and immune responses and may be a key contributor to the development of muscular dystrophy.

Once Hartgerink and his team started to investigate the phenomenon, they found that even without additives their MDP is rapidly infiltrated by host cells, provokes a temporary inflammatory response, does not develop a fibrous capsule, supports the infiltration of a mature vascular network and recruits nerve fibers.

But she and her UPenn colleague Drew Weissman found a way to tame cells» typical inflammatory response by modifying one of mRNA's four building blocks, uridine.

The nanoparticles work by binding to the cells that cause the inflammation — inflammatory monocytes — and diverting them to the spleen.

«Inflammatory arthritis is caused when immune cells are recruited from the blood into the joint in a highly regulated process controlled by chemoattractants and adhesion receptors,» says Andrew Luster, MD, PhD, chief of the MGH Division of Rheumatology, Allergy and Immunology, director of the CIID and senior author of the report.

They showed that rapamycin reduced the secretion of inflammatory cytokines from senescent cells in culture and in mice by suppressing the mTOR pathway, which promotes growth.

When activated by inflammatory markers in the gut, it sends a signal to the brain, where immune cells produce proteins such as IL - 6, leading to increased metabolism (and hence decreased levels) of the «happiness hormone» serotonin in the brain.

The study published in Cell Death and Disease showed that aspirin slows down the growth of mesothelioma by blocking the carcinogenic effects of the inflammatory molecule, High - Mobility Group Box 1 (HMGB1).

The team led by Professor Bozec turned off the oxygen sensor HIF in B cells and observed that this prevented the resolution of inflammation, leading to chronic inflammatory diseases.

A certain cytokine, or small protein that helps cells communicate during immune responses, can control whether immune cells promote or suppress inflammatory bowel disease, a finding that could lead to new treatments, according to a study led by Georgia State University.

In healthy skin, CD49a + and CD49a cells are dormant, but quickly respond with inflammatory and cytotoxic effects when stimulated by IL - 15, a protein secreted from skin cells as a rapid - response defence against microbial attack.

Cells in the innate immune system respond immediately by secreting inflammatory factors called cytokines to stop the spread of infection.

Its depletion of nucleotides leaves HIV capable of making just a few incomplete pieces of DNA that cause great harm to their host by stimulating an inflammatory response, causing nearby CD4 + T cells to commit suicide.

Gregory F. Sonnenberg, PhD, research associate in the Department of Medicine, Gastroenterology Division, and the Institute for Immunology at the Perelman School of Medicine, University of Pennsylvania, with postdoctoral researcher Matthew Hepworth, PhD, report in Nature that innate lymphoid cells (ILCs) directly limit the response by inflammatory T cells to commensal bacteria in the gut of mice.

What's more, mice with the selective deletion of MHCII in ILCs also developed inflammatory bowel disease, which was driven by aberrant CD4 + T - cell responses to commensal bacteria.

This, as with RORγt - deficient mice, selective deletion of MHCII in ILCs resulted in hyperactive T - cell responses directed against commensal bacteria and systemic inflammatory responses, all of which could be alleviated by depletion of commensal bacteria with broad - spectrum antibiotics.

An international research team headed by the rheumatologist Dr Andreas Ramming at Friedrich - Alexander - Universität Erlangen - Nürnberg (FAU) has now managed to identify an immune system cell type that can be used in a targeted attempt to control the inflammatory response in arthritis patients.

A team of investigators led by Rohit Kohli, MBBS, MS, of Children's Hospital Los Angeles, has identified key inflammatory cells involved in nonalcoholic fatty liver disease.

Researchers compared the inflammatory response of control - treated versus simvastatin - treated cells to RV by measuring CXCL10 secretion, an implicated therapeutic target for virus - induced asthma exacerbations.

They injected into mice with an inflammatory skin disease both mutated and healthy immune cells and succeeded in comparing the paths taken by each of the cells inside the same animal.

Professor Bowles, who referred to the research in a panel discussion on «Nature's Marvellous Medicines» at the recent Royal Society Summer Science Exhibition, said: «We were measuring how flavonoids affected the production of inflammatory mediators by cells stimulated by microbial products.

Children with behavioral problems may be at risk of many chronic diseases in adulthood including heart disease, obesity, diabetes, as well as inflammatory illnesses (conditions which are caused by cell damage).

The team's findings may also be relevant to inflammatory disorders that affect other parts of the body, such as the linings of the gut and bowel, which, like the skin, are replenished by epithelial stem cells.

Building on that work, the current paper looked at a less lethal strain, the H1N1 «swine flu,» that does not infect neurons, but which, the researchers showed, still caused inflammation in the brain via inflammatory chemicals or cytokines released by immune cells involved in fighting the infection.

The team found that inflammatory damage in the heart can not occur without the help of macrophages and dendritic cells made by the spleen, and that heart failure is to some degree an autoimmune disease.

«By exposing human colonic organoids to inflammatory triggers, we can now learn how the cell lining of the colon and the supporting cells beneath cooperate to respond to inflammation,» Munera said.

Left: mast cells are activated by allergens reacting with IgE bound to IgE receptors on the mast cell surface to trigger the release of histamine and other inflammatory mediators that orchestrate an allergic response including recruitment of inflammatory cells.

«Conversely, the necrotic part of the tumor is driven by a distinct set of glioma stem cells utilizing the BIM1 pathway and are characterized by a mesenchymal, inflammatory cell type dependent on glucose metabolism in the absence of oxygen.

They show that highly purified NS1 acts as a pathogen - associated molecular pattern (PAMP) that activates mouse macrophages and human peripheral blood mononuclear cells (PBMCs) in culture via TLR4, resulting in release of inflammatory cytokines — an effect that was blocked by either a TLR4 antagonist or an anti-TLR4 antibody.

These results suggest that response to inflammatory cytokines by endothelial cells is not required for NS1 to cause blood vessel leakage.

This may be of particular importance in the ageing lung as pulmonary infections are the primary cause of morbidity and mortality in the elderly, as discussed by Boe et al. 11 Innate cells appear to have reduced TLR signalling via MAPK and NFƙB resulting in reduced inflammatory cytokine production as well as altered chemotaxis responses, decreased phagocytosis and antigen presentation capacity.

MicroRNA - 93 inhibits inflammatory responses and cell apoptosis after cerebral ischemia reperfusion by targeting interleukin - 1 receptor - associated kinase 4.