Sentences with phrase «by keratinocyte»

... Traditionally, broadband UVB phototherapy has been used to treat psoriasis, which is an inflammatory skin disease, characterized by keratinocyte hyperproliferation with 1 - 2 percent prevalence in the general population.

Adipocyte Metabolism in Adipocyte Fatty Acid Binding Protein Knockout mice (aP2 - / --RRB- After Short - Term High - Fat Feeding: Functional Compensation by the Keratinocyte Fatty Acid Binding Protein.

Gianneschi and his team found that the synthetic melanin nanoparticles in their experiments were not only absorbed and distributed normally by the keratinocytes in the epidermis, but they also protected human skin cells from UV radiation damage.

Not exact matches

Importantly, the team identified a set of psoriasis - related genes in keratinocytes that are regulated by IL - 17A.

New results from a clinical trial involving more than 900 military veterans at high risk for keratinocyte carcinoma skin cancer provides evidence that using the generic skin cream fluorouacil 5 percent for two to four weeks may reduce the risk of a squamous cell carcinoma (SCC) needing surgery by 75 percent within a year.

The new findings suggest that Neanderthal genetic variants increase the risk of developing sun - triggered skin lesions known as keratoses, which are caused by abnormal keratinocytes.

Keratinocytes and dermal fibroblasts, which form the connective tissue in skin, responded to increased TWEAK activity by producing a number of chemoattractive and pro-inflammatory factors commonly found in atopic dermatitis and psoriasis.

Starting with procedures other research teams had previously worked out to convert iPSCs into keratinocytes, Xu's team demonstrated that by carefully controlling the timing of the growth factors the cells received, they could force the iPSCs to generate large numbers of epithelial stem cells.

The top four images, from left to right, show Keratinocyte - derived neural crest stem cells turning into neurons as shown by typical neuronal morphology.

Genodermatoses are characterized by genetic disorders of the skin affecting mainly either keratinocytes or melanocytes the two majors cell types of the epidermis.

(1) Antimicrobial Peptide LL - 37 Produced by HSV -2-Infected Keratinocytes Enhances HIV Infection of Langerhans Cells.

BB: Yes, I got a few questions and one question was asked by Dean, and he asked about whether we have any experience with direct reprogramming of keratinocytes to neurons?

Cell therapy, as envisaged by the teams of I - Stem, is primarily based on the identification of experimental protocols that can specifically guide differentiation of pluripotent cells to a cell fate, which presents a interest for the replacement of the defective cell population from the patient (the striatal neurons for Huntington's disease, the cells of the retinal pigment epithelium for retinitis pigmentosa, keratinocytes for genodermatoses, etc.).

Homogenous and functional population of keratinocytes and melanocytes derived from pluripotent stem cells were generated by designing a multi-step sequential protocol respecting the chronobiology of epidermis formation during human ontogenesis.

Apparently, keratinocytes exhibit a non-permissive chromatin and, hence, can not be reprogrammed by the BAM combination of factors.

Induction of GITRL expression in human keratinocytes by Th2 cytokines and TNF - α: implications for atopic dermatitis.

This differentiation is triggered by the endogenous Notch inhibitor Numb, which is upregulated in the stem cells by Wnt7a derived from UV - irradiated keratinocytes.

Rapid spreading and mature hemidesmosome formation in HaCaT Keratinocytes induced by incubation with soluble laminin - 5r.

The researchers then successfully prodded what they call keratinocyte - derived iPS cells or KiPS cells to distinguish them from fibroblast - derived iPS cells into becoming all the cell types in the human body, including heart muscle cells and dopamine - producing neurons, which are affected by Parkinson's disease.

In a study published in Molecular & Cellular Proteomics, researchers at the University of Freiburg led by Jorn Dengjel performed a global transcriptome and proteome profiling comparing primary DEB keratinocytes to normal human keratinocytes.

The research, described in the journal Stem Cells under the title «Reprogramming Postnatal Human Epidermal Keratinocytes Toward Functional Neural Crest Fates,» was supported by grants from the National Institutes of Health.

Primary keratinocytes exhibit three typical clonal morphologies represented by holoclones, meroclones, and paraclones, with holoclones containing self - renewing stem cells, and meroclones and paraclones containing more mature and differentiated cells.

Pioneering work by Barrandon and Green more than 20 years ago (2) showed that when primary human keratinocytes were put in culture, their abilities to establish a clone were related to the heterogeneity in cell size — only cells ≤ 11 μm in diameter could form a clone whereas cells ≥ 12 μm were irreversibly committed to terminal differentiation.

Melanin produced by melanocytes, is stored within melanosomes and is transferred to keratinocytes by a process known as cytocrinia (the same process by which melanin is transferred, in a normal epidermis, from melanocytes to keratocytes).

The presence of acantholytic keratinocytes surrounded by neutrophils is very suggestive of PF.3 In these cases, acantholytic keratinocytes are often seen in «rafts» (i.e., several cells close together).

Canine progenitor epidermal keratinocytes express various inflammatory markers, including interleukin - 8 and CD40, which are affected by certain antibiotics.