Sentences with phrase «by kidney cells»

Paolo Fiorina, MD, PhD (Boston Children's Hospital / Harvard Medical School) and his colleagues have discovered that a receptor called B7 - 1 is expressed by kidney cells during the progression of diabetic nephropathy.

Not exact matches

«But at some point we'll be able fabricate a biodevice from a patient's own cells that will duplicate the most important functions of a kidney and that won't be rejected by the patient's immune system.»

Erythropoietin is a hormone that's made by the kidneys, and it tells the body to make more red blood cells.

Renal cell carcinoma, also known by the eponym Grawitz tumor, is the most common form of kidney cancer arising from the renal tubule.

Dunsby and colleagues used it to measure glucose uptake, indicated by a fluorescent biosensor, in multicellular kidney cell spheroids.

Fussenegger created his biological calculator by engineering an embryonic kidney cell to respond to two different chemicals: erythromycin (an antibiotic) and phloretin (a compound found in apple trees).

Endocytosis of Frizzled 4 (Fz4) in human embryonic kidney 293 cells was dependent on added Wnt5A protein and was accomplished by the multifunctional adaptor protein β - arrestin 2 (βarr2), which was recruited to Fz4 by binding to phosphorylated Dvl2.

The remainder are absorbed by other cells, including those in the liver, spleen and kidneys.

Two years ago, he and his colleagues reported in Aging Cell that cutting the calories ingested by mice by 30 % for up to 4 weeks protected the rodents» kidneys when their blood supply was cut off and then restored.

The problem is that the body breaks down and eliminates real hemoglobin that is not protected by red blood cells, a process that can be toxic to the kidneys, constrict blood vessels (resulting in hypertension), and cause inflammation.

In previous studies, researchers have successfully differentiated stem cells into heart, liver, pancreas or nerve cells by adding certain chemicals, but kidney cells have proved challenging.

It also illustrates the mechanisms by which dysfunction of mitochondria — the power generators of the cell — affects kidney disease.

«This is the first study to show the actual cell behaviors caused by mutations in genes causally linked to polycystic kidney disease, an important new step in the path towards treatment,» said Dr. Robert L. Bacallao, associate professor of medicine at the IU School of Medicine in Indianapolis.

Cells were transplanted to the kidney capsule and photo was taken two weeks later by which time the beta cells are making insulin and have cured the diabetes in the mCells were transplanted to the kidney capsule and photo was taken two weeks later by which time the beta cells are making insulin and have cured the diabetes in the mcells are making insulin and have cured the diabetes in the mouse.

By receiving transplants of bone marrow cells along with the new kidney, four of five transplant patients with end - stage renal disease were able to stop taking immunosuppressive drugs within about one year after surgery.

«First, by genetically modifying the iPS cells, we created human kidney tissue in vitro with green fluorescence.

By contrast, ccRCC kidney cancer cells contain few mutations, yet some patients even with advanced, metastatic disease respond well to immunotherapy.

«Also, by using iPS cells from patients, development of new drugs and clarification of the causes of kidney disease are also expected.»

Researchers led by Van Allen and Choueiri sought an explanation for why some patients with a form of metastatic kidney cancer called clear cell renal cell cancer (ccRCC) gain clinical benefit — sometimes durable — from treatment with immune checkpoint inhibitors that block the PD - 1 checkpoint, while other patients don't.

Next, the researchers would like to investigate how to culture the other types of progenitor cells that are required for a full kidney, in addition to the nephrons formed by NPCs.

Progressive kidney diseases, whether caused by obesity, hypertension, diabetes, or rare genetic mutations, often have the same outcome: The cells responsible for filtering the blood are destroyed.

The study, led by Katalin Susztak, MD, PhD, a professor of Renal - Electrolyte and Hypertension and Genetics, also identified three novel cell populations, along with all previously described kidney cell types.

Reporting in Science, a team led by researchers from the Broad Institute of MIT and Harvard, Brigham and Women's Hospital, and Harvard Medical School describes a new approach to prevent death in these essential kidney cells.

In a related Comment published today in The Lancet, Jonathan Barasch, MD, PhD, professor of medicine and pathology and cell biology at CUMC, and colleagues Drs. Joseph Bonventre (Harvard Medical School, Brigham and Women's Hospital) and Richard Zager (University of Washington Medicine) explain that the blood test, which measures serum creatinine — a waste product that is removed by the kidneys and excreted in urine — only offers a snapshot of the kidney's function at a given moment, which can vary depending on individual factors such as body size and muscle mass.

By transferring the gene for melanopsin into human embryonic kidney cells, synthetic biologist Martin Fussenegger of the Swiss Federal Institute of Technology in Zurich and colleagues made these cells light - sensitive as well.

A higher intake by postmenopausal women of the natural antioxidant lycopene, found in foods like tomatoes, watermelon and papaya, may lower the risk of renal cell carcinoma, a type of kidney cancer.

Each patient then received a kidney from a genetically mismatched relative or unrelated donor; the concoction of donor cells processed by Ildstad's team was given a day later.

Harvard Stem Cell Institute scientists at Brigham and Women's Hospital have found the cellular origin of the tissue scarring caused by organ damage associated with diabetes, lung disease, high blood pressure, kidney disease, and other conditions.

abdominal pain (caused by abnormal blood cells building up in organs like the kidneys, liver, or spleen)

It also illustrates the mechanisms by which dysfunction of mitochondria - the power generators of the cell - affects kidney disease.

Recently, we showed that bortezomib treatment in mice bearing breast and kidney tumors provided host survival benefit by amplifying tumor cell caspase8 activation, CD8T cell effector molecules via increased NotchNFkB crosstalk and Fas ligandmediated lysis of tumor cells.

An anti-PD-1 antibody developed by Bristol - Myers Squibb generates excitement with results from a phase I trial showing that, among 236 patients with various types of cancer, the treatment shrank tumors in 28 percent of melanoma patients, 30 percent of patients with kidney cancer, and 18 percent of patients with advanced non-small cell lung cancer.

By age 2, the mice had some rat cells in their kidney, lung, pancreas, liver, and brain.

Injury to the kidney's tubular cells is one potential mechanism by which those metabolites might lead to kidney failure.

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Regulatory T - cell generation and kidney allograft tolerance induced by mesenchymal stem cells associated with indoleamine 2,3 - dioxygenase expression.

Tyrosine - dependent basolateral targeting of human connexin43 — eYFP in Madin — Darby canine kidney cells can be disrupted by the oculodentodigital dysplasia mutation L90V.

Our laboratory has studied the role of various proprotein convertases in the degradation and cell biology of FGF - 23, a peptide hormone secreted by bone cells which controls phosphate metabolism via its action in the kidney.

This research was supported by the NIH (R01 AR062368, R01 AR062920 to A.J.G and R01 DK055679, R01 DK059888, DK055679, DK059888, and DK089763 to A.N.), and J.R.S. is supported by the Intestinal Stem Cell Consortium (U01DK103141), a collaborative research project funded by the National Diabetes and Digestive and Kidney Diseases (NIDDK) and the National Institute of Allergy and Infectious Diseases (NIAID), and by the NIAID Novel, Alternative Model Systems for Enteric Diseases (NAMSED) consortium (U19AI116482), PHS Grant UL1TR000454 from the Clinical and Translational Science Award Program, and a seed grant from the Regenerative Engineering and Medicine Research Center between Emory University, Georgia Tech and the University of Georgia.

Adult stem / progenitor cells are present in many organs and tissues, e.g., bone marrow, teeth, heart, gut, kidney and liver, and remain quiescent for long period of time until activated by a disease or injury trigger.

This has been evidenced by 1) increased acinar cell necrosis, 2) increased serum amylase and lipase, 3) higher hepatic damage, 4) altered liver function test, 5) increased kidney damage, 6) increase in serum urea and creatinine, 7) altered distribution of pancreatic cells, 8) increased vacoulation and irregular islets, and 9) mild fibrosis in exocrine regions.

Erythropoietin (often shortened to EPO) is a naturally occurring hormone, secreted by the kidneys, whose function is to regulate red blood cell production.

4/22/2008 Fat - Cell Hormone Linked to Kidney Disease Reduced levels of a hormone produced by fat cells and linked to the development of insulin resistance may also be related to a higher risk of kidney disease, according to a study led by researchers at the University of California, San Diego School of... MKidney Disease Reduced levels of a hormone produced by fat cells and linked to the development of insulin resistance may also be related to a higher risk of kidney disease, according to a study led by researchers at the University of California, San Diego School of... Mkidney disease, according to a study led by researchers at the University of California, San Diego School of... More...

ARANESP ® is used to treat anemia, a deficiency in the number of red blood cells, caused by chronic kidney failure in patients both on dialysis and not on dialysis.

HuH - 7 (human HCC), HepG2 (human hepatocellular blastoma), 293T (human embryonic kidney fibroblast), HeLa (human cervical cancer cells), NIH 3T3 (murine fibroblast), and HCT116 (human colon cancer) and its derived cell line HCT116 p21 − / − (kindly provided by Dr. B. Vogelstein, Howard Hughes Medical Institute, Chevy Chase and the Sydney Kimmel Comprehensive Cancer Center of the Johns Hopkins University School of Medicine, Baltimore, MD; ref.

Studying cells from the stomach and pancreas in humans and mice, as well as mouse kidney and liver cells, and cells from more than 800 tumor and precancerous lesions in people, the researchers found when tissue is injured by infections or trauma, mature cells can revert back to a stem - cell state in which they divide repeatedly.

â $ œWe have solved a major obstacle of using anti-miRNA as a therapeutic by being able to do a targeted delivery to only inflamed endothelial cells while all other tissues examined, including liver, lung, kidney, blood cells, spleen, etc showed no detectable side - effects, â $ Jo says.

Uromodulin (or Tamm - Horsfall protein) is the most abundant protein in normal urine, specifically produced in the kidney by epithelial cells of the thick ascending limb (TAL) of Henle's loop.

He is building an artificial implantable kidney with microchip filters and living kidney cells that will be powered by a patient's own heart.

Vitamin D is converted into its active form primarily in the kidneys in an endocrine - regulated process, but a small amount of vitamin D activation occurs in nonrenal cells and is regulated by inflammation.