Sentences with phrase «by killing tumor cells»

Not exact matches

A heckler interrupted Vice President Joe Biden during a speech on Saturday, alleging the VP's son Beau Biden was killed by a tumor caused by radiation from cell phones, which prompted boos from the audience.

Chemotherapy drugs designed to kill tumors may actually encourage ovarian cancer by stimulating the growth of cells that give rise to the malignancy, a new study finds.

Traditional genetic approaches together with the new wealth of genomic information for both human and model organisms open up strategies by which drugs can be profiled for their ability to selectively kill cells in a molecular context that matches those found in tumors.

In the Cell study, Dr. Massagué, with Fellow Manuel Valiente, PhD, and other team members, found that in mouse models of breast and lung cancer — two tumor types that often spread to the brain — many cancer cells that enter the brain are killed by astrocytes.

Rubinstein said checkpoint therapies work by cutting the brake cables on the white bloods cells that are inherently able to kill tumor cells.

The team led by Andreas Plückthun, Director of the Department of Biochemistry at the University of Zurich, involving postdoc Rastik Tamaskovic and PhD student Martin Schwill, has now found out why these antibodies merely slow tumor growth rather than killing off the cancer cells.

An experimental drug in early development for aggressive brain tumors can cross the blood - brain tumor barrier, kill tumor cells and block the growth of tumor blood vessels, according to a study led by researchers at the Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James).

By hitting breast cancer cells with a targeted therapeutic immediately after chemotherapy, researchers from Brigham and Women's Hospital (BWH) were able to target cancer cells during a transitional stage when they were most vulnerable, killing cells and shrinking tumors in the lab and in pre-clinical models.

Although proteasome inhibitors are very efficient in selective killing of cancer tumor cells grown in a dish (in - vitro), their success in the clinic has largely been undermined by the development of resistance — mechanisms of which are poorly understood.

One form of pancreatic cancer has a new enemy: a two - drug combination discovered by UF Health researchers that inhibits tumors and kills cancer cells in mouse models.

«We know that if you take these tumor cells out of a patient and put them in a petri dish, they can be killed by chemotherapy,» Beatty said.

In laboratory studies, daratumumab caused the targeted killing of CD38 - carrying tumor cells by several distinct and potent mechanisms, including some that involve the immune system.

The tumor suppressor p53 does all it can to prevent oncogenes from transforming normal cells into tumor cells by killing defective cells or causing them to become inactive.

This paracrine effect was brought about by the tumor suppressor Par - 4, which specifically kills cancer cells.

A team led by neuroscientist Khalid Shah, MS, PhD, who recently demonstrated the value of stem cells loaded with cancer - killing herpes viruses, now has a way to genetically engineer stem cells so that they can produce and secrete tumor - killing toxins.

Some cell types were not killed by treatment with PAL, suggesting it could be used as a specific tumor therapy.

«A few years ago we recognized that stem cells could be used to continuously deliver these therapeutic toxins to tumors in the brain, but first we needed to genetically engineer stem cells that could resist being killed themselves by the toxins,» he said.

Chemotherapies are potent toxins delivered into the bloodstream to kill tumor cells throughout the body by damaging DNA in rapidly dividing cells.

Cancer immunotherapies work by activating T cells to kill tumors.

They found that in all nine cases, their data matched the outcomes seen in patients, as measured by clinical protein biomarkers found in the bloodstream, which are used by doctors to determine whether a drug is killing the tumor cells.

«The nanoparticle mimics the behavior of NADPH oxidase, an enzyme used by immune cells to kill tumor cells and infectious agents.

NK cells require active STAT5 to kill tumor cells; however, when STAT5 is absent or inhibited, NK cells do the opposite: they accelerate cancer progression by promoting angiogenesis.

Another view is that tumors can become resistant to therapy by a process called cell fate decision, by which some tumor cells are killed by therapy and others become cancer stem cells.

«Our findings suggest a simple strategy to kill metastatic melanoma — regardless of cell type within the tumor — by combining anticancer drugs with diabetes drug,» Herlyn said.

The tubes responded to the laser blast by vibrating, which created enough heat to kill surrounding tumor cells.

That light is absorbed by the chlorine - based molecules, which then excite nearby oxygen molecules, creating a highly reactive form of oxygen, known as singlet oxygen, that rips apart nearby biomolecules and kills the tumor cell.

They used the gene - editing CRISPR / Cas9 technique to sift the genomes of melanoma cells for changes that made tumors resistant to being killed by immune T cells, which are the main actors in the immune system response against infections and cancer cells.

One reason for this, explains Hai - Hui (Howard) Xue, MD, PhD, UI professor of microbiology and immunology, is that there are two kinds of tumor cells — bulk leukemia cells that can be killed by TKI drugs, and a subset of cells called leukemia stem cells, which are resistant to TKIs and to chemotherapy.

The therapy not only killed cells at the primary tumor site, but also in distant metastases by «bystander» antitumor activity driven by the secreted MDA - 7 / IL - 24 protein.

These tumors might yield to a new kind of drug known as a PARP inhibitor that kills cancer cells by hijacking the cell's ability to mend DNA breaks.

Furthermore, when the team, lead by cell biologist Valeria Fantin, implanted LDH - A-normal cancer cells and LDH - A-deficient cancer cells in mice, LDH - A-deficient tumors grew more slowly and took two - and - a-half times longer, on average, to kill the mice than LDA - A-positive tumors.

Technology such as this, scientists said, may have a promising future in the identification and surgical removal of malignant tumors, as well as using near - infrared light therapies that can kill remaining cancer cells, both by mild heating of them and generating reactive oxygen species that can also kill them.

Led by Ludwig Lausanne investigator Alexandre Harari and George Coukos, director of the Ludwig Institute for Cancer Research, Lausanne, the study shows that ovarian tumors harbor highly reactive killer T cells — which kill infected and cancerous cells — and demonstrates how they can be identified and selectively grown for use in personalized, cell - based immunotherapies.

In the study, the biomedical engineers killed the cancerous tumor cells within days, by injecting liposomes armed with TRAIL (Tumor necrosis factor Related Apoptosis - Inducing Ligand) that attach to «natural killer» cells — a type of white blood cell — residing in the lymph ntumor cells within days, by injecting liposomes armed with TRAIL (Tumor necrosis factor Related Apoptosis - Inducing Ligand) that attach to «natural killer» cells — a type of white blood cell — residing in the lymph nTumor necrosis factor Related Apoptosis - Inducing Ligand) that attach to «natural killer» cells — a type of white blood cell — residing in the lymph nodes.

Drugs used in chemotherapy, such as ifosfamide and doxorubicin hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.

25: Radaeva S, Sun R, Jaruga B, Nguyen VT, Tian Z, Gao B. Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D - dependent and tumor necrosis factor - related apoptosis - inducing ligand - dependent manners.

In these experiments, the virus managed to infect and destroy only a small proportion of tumor cells directly, the researchers found, but within five days of the initial infection, the rest of the tumor began to be killed by a powerful immune reaction.

Drug from Mediterranean Weed Kills Tumor Cells Scientists at the Johns Hopkins Kimmel Cancer Center, working with Danish researchers, have developed a novel anticancer drug designed to travel — undetected by normal cells — through the bloodstream until activated by specific cancer protCells Scientists at the Johns Hopkins Kimmel Cancer Center, working with Danish researchers, have developed a novel anticancer drug designed to travel — undetected by normal cells — through the bloodstream until activated by specific cancer protcells — through the bloodstream until activated by specific cancer proteins.

This study will combine direct tumor cell killing (TK) and immune - mediated stimulatory (Flt3L) gene transfer approaches delivered by first generation adenoviral vectors.

Maureen Su, MD, and colleagues report on a potential new way to fight melanoma by blocking one of the immune system's checks and balances, thus freeing immune cells to attack tumors and kill cancer cells.

The featured lung cancer study, for instance, not only used synthetic vitamin E (tocopheryl) but also neglected to include any tocotrienols, which have previously been shown to kill cancer stem cells, the most malignant of all cells with a tumor.5 As noted by Dr. Andrew Saul, the study was set up to fail: 6

Scientists who are in the process of developing prototypes for potential new anticancer agents that selectively kill tumor cells by interfering with the regulation of intracellular pH, have found that alkaline treatments do NOT have the desired effect - but strongly acidic treatments do.13

The numerous flavonoids found in astragalus appear to enhance cell - mediated immunity by increasing the number of T - helper cell type 2 cytokines, increasing levels of tumor necrosis factor and interleukin - 6, which stimulates the activity of macrophages, responsible for killing potentially harmful cells.

We previously showed that calorie restriction and alternate daily fasting works synergistically with doses of radiation therapy to enhance cancer cell kill and slow tumor growth, by decreasing several metabolic pathways heavily related to dietary carbohydrates and insulin.

«They really got a big bang for the buck, and one of the cancer cells that should be killed by their protocol is the cell that's driving the entire tumor here.

Whether it turns into a tumor or not is determined by your immune system's ability to kill the cancerous cell before it multiplies and possibly becomes carcinogenic.

These rays are used to kill cancer cells, shrink tumors, and treat cancers that are not affected by chemotherapy or safely removable by surgery.

Radiation therapy machines treat cancer by delivering high energy radiation to a tumor, killing the tumor cells.

Audi spent a couple of days in the hospital on supportive care after starting chemotherapy to help avoid side effects of tumor lysis, a syndrome that can occur and make the patient very ill when a large volume of tumor cells are rapidly killed by chemotherapy.

Today's effective treatment options can actually cure the disease by killing off the abnormal tumor cells while leaving the normal thyroid cells undamaged, resulting in a normal life span for many affected cats.