Takano T, Azuma N, Satoh M, Toda A, Hashida Y, Satoh R, Hohdatsu T. 2009 Neutrophil survival factors (TNF - alpha, GM - CSF, and G - CSF) produced
by macrophages in cats infected with feline infectious peritonitis virus contribute to the pathogenesis of granulomatous lesions.
... After treatment of macrophages with curcuminoids, Aβ uptake
by macrophages of three of the six AD patients was significantly (P < 0.001 to 0.081) increased.
«Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and
removal by macrophages»
These proteins most closely resembled those made by endothelial cells in the lymphatic system, not the proteins
made by macrophages or other immune cells.
Their research shows that M. avium not only avoids being
killed by macrophages, but even avoids being discovered by them.
«The current model of disease is that when Mtb bacteria are inhaled, they reach the end of the lung — the alveolus — and then are
ingested by a macrophage, a type of white blood cell that swallows and kills invading bacteria,» Dr. Shiloh said.
«First, the effect of cortisone is
mediated by macrophages which usually serve as scavenger cells in an immune response.
Particles that are more spherically symmetric can be engulfed in one fell
swoop by macrophages, but that is more difficult for such filamentous particles.»
Neurological heterotopic ossification following spinal cord injury is
triggered by macrophage - mediated inflammation in muscle.
Oxidative stress - mediated (sex - specific) loss of protection against type - 2
diabetes by macrophage migration inhibitory factor (MIF)-173 G / C polymorphism
«After macrophage depletion, we observed that the normal intestinal movements are irregular, probably because the muscular contractions were poorly coordinated, suggesting that intestinal movements are
regulated by macrophages,» Bogunovic said.
Cellular stress signals
sent by macrophages amplify neuroinflammation, provide novel drug targets for MS therapy
Our analysis suggests that loss of transplanted cells is associated with infiltration of the subretinal
space by macrophages / microglia.
When this process starts, the damaged muscle fibers are broken down by lysosomal proteases, free radicals and many other compounds
released by the macrophages.
These lipids get oxidized and are
consumed by macrophages, creating a «fatty streak», which can be found as early as teenage years [28].
The study shows that test subjects with wheat germ extract in their diet have increased TNF
secretion by the macrophages and stimulating NK cell activity (Natural Killer cells).
In the lymph nodes, «B» type lymphocytes, through their derivative «plasma cells», make antibodies to the antigens
brought by the macrophages (humoral immunity); and «T» type lymphocytes prepare themselves to attack the foreign antigens (cellular immunity).
«After M. avium is
engulfed by the macrophage, it avoids getting degraded and hides in a separate compartment inside the macrophage, a vesicle, where it is no longer recognized — the sensors are either not present or else don't react to the presence of the bacteria.
They first showed that mice with severed sensory nerves produce excessive BH4, churned out both by the injured nerve cells themselves and
by macrophages — immune cells that infiltrate damaged nerves and inflamed tissue.
A paper from cardiologist Aloke Finn and colleagues (published Wednesday, Aug. 5 in Nature Communications) describes how the protein CD163, produced
by macrophages, puts the brakes on muscle repair after ischemic injury in mice.
In a classic minimum inhibitory concentration assay, a highly virulent strain of MRSA that had been engulfed
by macrophages could not be killed at clinically relevant antibiotic concentrations that readily killed free MRSA.