Sentences with phrase «by medicinal chemistry»

Promising compounds are being generated using established high throughput screening by medicinal chemistry and are being tested in preclinical animal models.

After the initial screening, potential «hits» were optimized by medicinal chemistry and tested for potency, specificity, and toxicity.

Not exact matches

Team leader Jonathan Dimmock, a medicinal chemistry researcher in the U of S College of Pharmacy and Nutrition, explained their compounds work by interacting with thiols, naturally occurring chemicals that perform several roles in cells.

Sylvie Garneau - Tsodikova's research aims to understand and combat bacterial and fungal resistance by using tools from medicinal chemistry, biochemistry, microbiology, and structural biology.

«The bactericidal mechanism of ODLs and the fact that they bind to a site on the ribosome not exploited by any known antibiotic are very strong indicators that ODLs have the potential to treat infections that are unresponsive to other antibiotics,» said Mankin, who is also professor of medicinal chemistry and pharmacognosy.

Douglas Thomas, associate professor of medicinal chemistry and pharmacognosy at UIC, and co-workers discovered that nitric oxide plays an important role in epigenetics — heritable alterations in gene expression caused by mechanisms other than changes in DNA sequence.