We looked at particular genes, called CDKN2A and CDK4, using the samples given for research
by melanoma families.
Not exact matches
Bolte's father, felled
by a
melanoma, had been a dapper Long Island attorney, and when his widow ran out of cash, banks foreclosed on the
family's two homes.
A new
family of genes coding for an antigen recognized
by autologous cytolytic T lymphocytes on a human
melanoma.
Some
families have far more cases of
melanoma than we would expect
by chance alone.
The most frequent high penetrance
melanoma gene found to be mutated in
melanoma families is CDKN2A and the protein produced
by the gene is called p16.
The strongest link between having a mutation in this particular gene in the
family and having multiple
family members with
melanoma, early onset, and so forth, was in Europe followed
by North America and then Australia.
And
by the way,
melanoma is a big deal in my
family — my grandfather died from it.