Sentences with phrase «by microglial»
The activation of Toll - like receptor 2, for example, triggers the release of proinflammatory cytokines by microglial cells (3).
https://www.the-scientist.com/ Not exact matches
Microglial cells may malfunction in neurodegenerative disorders such as Alzheimer's disease, and there is some evidence that they worsen the damage caused by a stroke.
Patients with major depressive disorder (MDD) have increased brain levels of a marker of microglial activation, a sign of inflammation, according to a new study in Biological Psychiatry by researchers at the University of Manchester, United Kingdom.
«The field now has two independent reports — our study and a 2015 report by Setiawan and colleagues in Toronto — showing essentially the same thing: that there is evidence for inflammation, more specifically microglial activation, in the brains of living patients during a major depressive episode,» said Dr. Talbot.
July 21, 2016 Antibiotic treatment weakens progression of Alzheimer's disease through changes in the gut microbiome Long - term treatment with broad spectrum antibiotics decreased levels of amyloid plaques, a hallmark of Alzheimer's disease, and activated inflammatory microglial cells in the brains of mice in a new study by neuroscientists from the University of Chicago.
Long - term treatment with broad spectrum antibiotics decreased levels of amyloid plaques, a hallmark of Alzheimer's disease, and activated inflammatory microglial cells in the brains of mice in a new study by neuroscientists from the University of Chicago.
In normal conditions, microglial cells do not make APOE; however, in disease conditions, they sense the brain damage and respond by churning out APOE.
The Nurr1 Activator 1, 1 - Bis (3 ′ - Indolyl)-1 -(p - Chlorophenyl) Methane Blocks Inflammatory Gene Expression in BV - 2 Microglial Cells by Inhibiting Nuclear Factor κB.
Moreover, recent data also show that in response to brain damage caused by aging, amyloid deposition, demyelination, and other insults, microglial cells activate several genes, including APOE, in order to more efficiently scavenge and clear tissue debris that are very rich in cholesterol due to the natural composition of the brain, which is mostly made of fats.
A microglial cell serves as a front - line sentry, monitoring its surroundings for suspicious activities and materials by probing its local environment.
Zhang W, Dallas S, Zhang D, Guo J - P, Wilson B, Miller DS, Chen B, Zhang W, McGeer PL, Hong J - S, Zhang J. Microglial PHOX and Mac - 1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha - synuclein.
Waksman et al. «The Central Cannabinoid Receptor (CB1) Mediates Inhibition of Nitric Oxide Production by Rat Microglial Cells», The Journal of Pharmacology and Experimental Therapeutics, 288 (3): 1357 - 1366, 1999.
Previously the long - term benefits of hematopoietic stem - cell transplantation in cerebral adrenoleukodystrophy (ALD) are thought to be mediated by donor - derived replacement of myeloid derived cells, possibly including microglial cells.
Decreased microglial activation through gut - brain axis by prebiotics, probiotics, or synbiotics effectively restored cognitive function in obese - insulin resistant rats.