Sentences with phrase «by multiple factors like»

This resting metabolic rate is determined by multiple factors like height, sex, as well as the genes you inherited from your parents and regardless of what you do, it can not be changed much.

Not exact matches

«Disease among sea stars is likely caused by multiple factors, not just one factor like SSaDV or rising temperature.

And even if such a demand existed, there was no evidence that genetic counseling could help patients with psychiatric disorders, which — like most of the more common diseases — are caused by a complex interplay of multiple genes and variants as well as environmental factors.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

«There are multiple interactive pathways and molecular mechanisms by which CR (calorie restriction) and IF (intermittent fasting) benefit neurons including those involving insulin - like signaling, FoxO transcription factors, sirtuins and peroxisome proliferator - activated receptors.

In fact, if the devs would have included more levels like the last (a multiple - stage boss fight with a colossal enemy weapon) the campaign's brevity would be overshadowed by its wow factor.

IMPACT was designed to control for variables like the class's income level and English - language proficiency, and scores teachers on two major factors: classroom skill, as determined by multiple evaluations, and results, based on students» improvement on standardized tests.

So - called factor indexes (and the beta strategies that follow them), like the MSCI USA Enhanced Value Index and iShares Edge MSCI USA Value Factor ETF (VLUE), screen for securities using multiple metrics, and weight them not by market capitalization, but by their exposure to value price multfactor indexes (and the beta strategies that follow them), like the MSCI USA Enhanced Value Index and iShares Edge MSCI USA Value Factor ETF (VLUE), screen for securities using multiple metrics, and weight them not by market capitalization, but by their exposure to value price multFactor ETF (VLUE), screen for securities using multiple metrics, and weight them not by market capitalization, but by their exposure to value price multiples.

The compensatory amount (22.47 lakh) was finalized by the Tribunal, keeping multiple factors like annual income (1.5 lakh) of the victim, loss of dependency and love, affection for her husband and kids.

Then, when you factor in an emergency day or two for inclement weather, it can feel less like you're juggling multiple balls and more like you are just getting pelted by them.