Sentences with phrase «by necrosis»

Studies showed that propolis caused cancer cells to die by necrosis.

Gross brain pathology from infants with presumed or laboratory - confirmed ZIKV infection, primarily from neuroimaging, closely resembles neuropathology associated with congenital cytomegalovirus (CMV).48 The most notable difference is the distribution of intracranial calcifications (ie, typically subcortical in congenital ZIKV infection and periventricular in CMV).48, 49 Such calcifications are likely dystrophic and related to cell death, either by necrosis, apoptosis, or both.50

But he believes that targeting cancers for destruction by necrosis and not by apoptosis, the other main pathway to cell death, holds great promise therapeutically.

Not exact matches

Because over 10 million people survive a stroke each year, Doyle hopes that biomarkers will help them track the progression of liquefactive necrosis, «and begin to tailor treatments that mitigate the secondary damage caused by this process,» he says.

NF - kB enables cancer cells to survive the pro-apoptotic influence of tumor necrosis factor that is released by tumor infiltrating macrophages;

They act by dampening part of the immune system called tumor necrosis factor (TNF).

The toxins produced by these particular microbes are capable of causing inflammation and necrosis (death and decay) of intestinal wall — hence the process is called enteritis necroticans.

The activation dynamics of the transcription factor NF - κB exhibit damped oscillatory behavior when cells are stimulated by tumor necrosis factor — α (TNFα) but stable behavior when stimulated by lipopolysaccharide (LPS).

Infliximab reduces symptoms and inflammation by targeting one of the proteins — called tumor necrosis factor (TNF)-- that leads to inflammation in IBD.

«This finding was quite tantalizing given the fact that mutations in the NUP62 protein were shown by other researchers to cause an infantile form of Huntington's disease called infantile bilateral striatal necrosis,» says Grima.

Researchers led by David Wallach of the Weizmann Institute of Science in Rehovot looked more closely at a receptor called p55, which binds to a suicide - promoting cytokine called tumour necrosis factor (TNF).

They found that microglia then responded to another protein found in the brain called ψ - interferon by producing free radicals containing nitrogen and a third protein called α - tumour necrosis factor.

By depriving the cancer cells of the amino acid cystine, the researchers were able to trigger a form of cell death called necrosis in mouse models of the disease.

Across multiple triple - negative breast cancer subtypes, inhibiting the androgen receptor greatly increased apoptosis (programmed cell death), inhibited growth and increased necrosis by 60 percent in animal models.

These human astrocytes apparently did so, the scientists suggest, by secreting a protein called tumor necrosis factor - α, which mouse astrocytes produce at much lower levels.

In the study, the biomedical engineers killed the cancerous tumor cells within days, by injecting liposomes armed with TRAIL (Tumor necrosis factor Related Apoptosis - Inducing Ligand) that attach to «natural killer» cells — a type of white blood cell — residing in the lymph nodes.

Such genes might include those for various cytokines — substances produced by cells of the immune system — such as tumour necrosis factor, interleukins and interferons.

Takeda K, Hayakawa Y, Smyth MJ, Kayagaki N, Yamaguchi N, Kakuta S, Iwakura Y, Yagita H, Okumura K. Involvement of tumor necrosis factor - related apoptosis - inducing ligand in surveillance of tumor metastasis by liver NK cells.

Antonio Lanzavecchia finds that efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte / macrophage colony - stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

It is mediated by the inflammatory cytokines interleukin - 1 and tumour - necrosis factor, both of which are produced in high amounts following sustained activation of Toll - like receptor 4 by LPS.

Han et al. demonstrated that in Caco2 cells, extracellular NAD + inhibited the binding of NF - kB to DNA by blocking the transcription of different genes involved in both inflammatory and aging pathways (interlukin - 6, interlukin - 1 beta, tumor necrosis factor alpha) 27.

The human genes for tumor necrosis factor (TNF - alpha), first identified by Lloyd J. Old and Elisabeth A. Carswell in 1975, and LT (TNF - beta) are cloned.

Estrogen improves cardiac recovery after ischemia / reperfusion by decreasing tumor necrosis factor - α.

Anna Huttenlocher, University of Wisconsin, USA Neutrophils in the Tumor Microenvironment Neutrophils, Wounds, and Cancer Progression Stefan Kaufmann, Max Planck Institute, Germany Pathology and immune reactivity: understanding multidimensionality in pulmonary tuberculosis Constitutive BAK activation as a determinant of drug sensitivity in malignant lymphohematopoietic cells Kathryn Moore, New York University, USA MicroRNA -33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis Lalita Ramakrishnan, University of Cambridge, UK Myeloid Growth Factors Promote Resistance to Mycobacterial Infection by Curtailing Granuloma Necrosis through Macrophage Replenishment Beth Stevens, Harvard University, USA Microglia: Dynamic Mediators of Synapse Development and Plasticity Do glia drive synaptic and cognitive impairment in disease?

Stress granule formation mediates the inhibition of colonic Hsp70 translation by interferon - γ and tumor necrosis factor - α.

Phosphorylation of tumor necrosis factor receptor CD120a (p55) by p42 mapk / erk2 induces changes in its subcellular localization.

Tumor necrosis factor alpha stimulates killing of Mycobacterium tuberculosis by human neutrophils.

Tumor necrosis factor alpha and inflammation disrupt the polarity complex in intestinal epithelial cells by a posttranslational mechanism.

25: Radaeva S, Sun R, Jaruga B, Nguyen VT, Tian Z, Gao B. Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D - dependent and tumor necrosis factor - related apoptosis - inducing ligand - dependent manners.

Regulation of the PKCθ - NF - κB axis in T lymphocytes by the tumor necrosis factor receptor family member OX40.

This has been evidenced by 1) increased acinar cell necrosis, 2) increased serum amylase and lipase, 3) higher hepatic damage, 4) altered liver function test, 5) increased kidney damage, 6) increase in serum urea and creatinine, 7) altered distribution of pancreatic cells, 8) increased vacoulation and irregular islets, and 9) mild fibrosis in exocrine regions.

Stem cells affect the infarcted myocardium via neovascularization, reduction of apoptosis and paracrine effect, they are able to increase myocardial perfusion, inhibit synthesis of pro-inflammatory cytokines (IL6 and TNFα) and promote expression of anti-inflammatory cytokines (IL10) minimizing the necrosis damage caused by local inflammatory reaction.

Ionizing radiation is a potent DNA damaging agent that interacts with cellular DNA and induces lesions in the irradiated cells and prevents cell proliferation and induces cell death by apoptosis or necrosis depending on the radiation dose.

L - arginine is a choice of molecule to induce AP as it causes dose - dependent selective necrosis of acinar cells by ROS and ER stress, also by inhibiting polyamine synthesis in acinar cells resulting in inhibition of protein metabolism [31, 32].

The tick feeding site shows ulceration at the location of hypostome penetration with mixed neutrophilic / eosinophilic / histiocytic inflammation and necrosis extending into the deep dermis accompanied by disorganization of the collagen bundles (Panel D).

Cells were gated on forward and side scatter followed by Lin (CD3, CD11c, B220, GR - 1 and NK1.1)- and Thy1.2 + CD127 + cells were analyzed for apoptosis by Annexin V and 7 - AAD staining or for necrosis using viability eFluor780 dye.

Liposuction did not significantly alter the insulin sensitivity of muscle, liver, or adipose tissue (assessed by the stimulation of glucose disposal, the suppression of glucose production, and the suppression of lipolysis, respectively); did not significantly alter plasma concentrations of C - reactive protein, interleukin - 6, tumor necrosis factor alpha, and adiponectin; and did not significantly affect other risk factors for coronary heart disease (blood pressure and plasma glucose, insulin, and lipid concentrations) in either group.

Recently, some other cytokines (such as tumor necrosis factor) or chemical drugs were also found to up - regulate several IFN - inducible gene family members (including RIG - G) through production of type I IFNs (37, 38), further indicating that the induction of RIG - G by ATRA in NB4 cells was tightly related with an IFNα autocrine pathway.

The extrinsic apoptotic pathway is activated by external signals through transmembrane tumour necrosis factor receptors (TNFRs) whose intracellular death domain interacts with downstream adaptors.

Delayed response to cold stress is characterized by successive metabolic shifts culminating in apple fruit peel necrosis

And according to recent studies conducted in Japan, the full ripe bananas with dark patches on their skin produce the largest quantity of TNF (Tumor Necrosis Factor), a cytokine that fights abnormal tumor cells in the body by stimulating the production of white blood cells and assisting their communication.

He said my hip problems (osteoarthritis and avascular necrosis) were likely exacerbated by my smoking, but his argument for quitting had more to do with my recovery.

Inflammation can be measured by testing several blood markers, including C - reactive protein (CRP), tumor necrosis factor (TNF) and interleukin - 6 (IL - 6).

Their antioxidant and anti-inflammatory activities are largely due to their abilities to scavenge the reactive oxygen species (ROS) and improvement of antioxidant status by attenuating the activity of NF - κB and suppressing the expression of several inflammatory cytokines and chemokines including monocyte chemotactic protein - 1 (MCP - 1), nitric oxide synthase, cyclooxygenases, lipoxygenases, cellular adhesion molecules, tumor necrosis factor and interleukins.

It was hypothesized that silver toxicity, as manifested by liver necrosis in laboratory rats, was due to silver induced inhibition of the synthesis of the seleno - enzyme glutathione peroxidase.

The research, which was funded by the Food and Drug Administration and other federal health agencies, contradicts numerous earlier studies that did find an increased risk of infection associated with the drugs, known as tumor necrosis factor (TNF) inhibitors.

C3G significantly upregulated the glucose transporter 4 (Glut4) and downregulated RBP4 in the white adipose tissue, which is accompanied by downregulation of the inflammatory adipocytokines (monocyte chemoattractant protein - 1 and tumor necrosis factor - alpha) in the white adipose tissue of the C3G group.

White adipose tissue messenger RNA levels and serum concentrations of inflammatory cytokines (tumor necrosis factor - α, interleukin - 6, and monocyte chemoattractant protein - 1) were reduced by C3G, as did macrophage infiltration in adipose tissue.

The numerous flavonoids found in astragalus appear to enhance cell - mediated immunity by increasing the number of T - helper cell type 2 cytokines, increasing levels of tumor necrosis factor and interleukin - 6, which stimulates the activity of macrophages, responsible for killing potentially harmful cells.

Necrosis, on the other hand, is unprogrammed tumor cell death caused by unnatural processes or disease.